Treatable traits: a comprehensive precision medicine approach in interstitial lung disease

Letter Critical Care Medicine

Patient Characteristics and Survival for Progressive Pulmonary Fibrosis Using Different Definitions

Yet H. Khor et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)

Article Critical Care Medicine

Validation of Proposed Criteria for Progressive Pulmonary Fibrosis

Janelle Vu Pugashetti et al.

Summary: This study found that a decline in FVC of >= 10% and six additional criteria can predict transplant-free survival in patients with non-IPF ILD.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)

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Article Critical Care Medicine

Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): a double-blind, double-dummy, randomised, controlled, phase 2b trial

Toby M. Maher et al.

Summary: In a randomized, double-blind clinical trial, it was found that rituximab is not superior to cyclophosphamide in treating connective tissue disease-associated interstitial lung disease (ILD). However, both treatment methods improved lung function and quality of life in patients within 24 weeks.

LANCET RESPIRATORY MEDICINE (2023)

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Article Critical Care Medicine

Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study

Joshua J. Solomon et al.

Summary: This study evaluated the safety, tolerability, and efficacy of pirfenidone for the treatment of patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD). The results showed that although it did not meet the primary endpoint, pirfenidone slowed the rate of decline in lung function in patients with RA-ILD.

LANCET RESPIRATORY MEDICINE (2023)

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Article Critical Care Medicine

Efficacy of Inhaled Treprostinil on Multiple Disease Progression Events in Patients with Pulmonary Hypertension due to Parenchymal Lung Disease in the INCREASE Trial

Steven D. Nathan et al.

Summary: The study showed that patients treated with inhaled treprostinil had better outcomes in terms of 6-minute walk distance and fewer clinical worsening events. There were fewer occurrences of multiple disease progression events in the inhaled treprostinil group, indicating a lower risk of further disease progression in these patients.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

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Article Critical Care Medicine

Association of BMI and Change in Weight With Mortality in Patients With Fibrotic Interstitial Lung Disease

Alessia Comes et al.

Summary: Underweight patients with fibrotic ILD have the highest mortality rate, while overweight and obese patients have the lowest mortality rate. Patients who experience a weight loss of at least 2 kg within 1 year have an increased risk of death in the subsequent year.

CHEST (2022)

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Article Respiratory System

The role of precision medicine in interstitial lung disease

Toby M. Maher et al.

Summary: The management of interstitial lung disease (ILD) can benefit from individualized treatment strategies that consider diagnostic classification and disease behavior. Biomarker-based approaches hold promise in precision medicine for ILD, with potential applications in staging, prognosis, and treatment response assessment. Artificial intelligence has the potential to redefine prognostic evaluation and improve individualized treatment algorithms.

EUROPEAN RESPIRATORY JOURNAL (2022)

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Article Respiratory System

Lung function trajectory in progressive fibrosing interstitial lung disease

Justin M. Oldham et al.

Summary: This study found that the change in lung function after satisfying progressive fibrosing interstitial lung disease (PF-ILD) criteria is closely associated with radiological progression of fibrosis. However, the impact may vary depending on the specific subtype of interstitial lung disease (ILD). These findings can inform future clinical trial design and emphasize the importance of considering ILD subtype when applying PF-ILD criteria.

EUROPEAN RESPIRATORY JOURNAL (2022)

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Article Respiratory System

Diagnosis, course and management of hypersensitivity pneumonitis

Mark Hamblin et al.

Summary: In this article, the authors discussed the diagnosis, classification, and treatment of hypersensitivity pneumonitis (HP), which is a complex and heterogeneous interstitial lung disease. They emphasized the importance of thorough evaluation and identification of fibrotic and progressive HP, and provided evidence-supported guidelines for the use of drugs in HP treatment.

EUROPEAN RESPIRATORY REVIEW (2022)

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Article Critical Care Medicine

Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline

Ganesh Raghu et al.

Summary: This article provides updates on the guidelines for idiopathic pulmonary fibrosis (IPF) and addresses the progression of pulmonary fibrosis in patients with interstitial lung diseases (ILDs) other than IPF. The recommendations are based on consensus and systematic reviews, aiming to provide evidence-based guidance for clinicians.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

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Article Respiratory System

Antigen identification and avoidance on outcomes in fibrotic hypersensitivity pneumonitis

Tananchai Petnak et al.

Summary: Our findings suggest that antigen identification and avoidance are associated with improved clinical outcomes in patients with fibrotic disease.

EUROPEAN RESPIRATORY JOURNAL (2022)

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Editorial Material Medicine, General & Internal

Treatable traits in asthma: moving beyond diagnostic labels

Vanessa M. McDonald et al.

MEDICAL JOURNAL OF AUSTRALIA (2022)

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Review Nutrition & Dietetics

Nutrition implications of intrinsic restrictive lung disease

Sylvia Rinaldi et al.

Summary: Restrictive lung disease is characterized by reduced lung volume and can be caused by intraparenchymal or extraparenchymal factors. This article provides an overview of interstitial lung disease (ILD) and emphasizes the role of nutrition management in ILD patients.

NUTRITION IN CLINICAL PRACTICE (2022)

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Article Cardiac & Cardiovascular Systems

Association of BMI with pulmonary function, functional capacity, symptoms, and quality of life in ILD

Michele R. Schaeffer et al.

Summary: Obesity is associated with poorer pulmonary function, functional capacity, dyspnea, and quality of life in patients with interstitial lung disease (ILD). Intentional weight loss may potentially improve lung function and functional capacity in obese ILD patients.

RESPIRATORY MEDICINE (2022)

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Article Respiratory System

Inhalational exposures in patients with fibrotic interstitial lung disease: Presentation, pulmonary function and survival in the Canadian Registry for Pulmonary Fibrosis

Cathryn T. Lee et al.

Summary: This study reveals the high prevalence of inhalational exposures among patients with fibrotic ILD, and finds that these exposures are associated with younger age at diagnosis, male gender, and family history of pulmonary fibrosis. Patients with inhalational exposure have improved transplant-free survival. These findings suggest that inhalational exposures may impact clinical outcomes in patients with ILD.

RESPIROLOGY (2022)

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Review Allergy

Effectiveness of Interventions Targeting Treatable Traits for the Management of Obstructive Airway Diseases: A Systematic Review and Meta-Analysis

Muhammad Rehan Sarwar et al.

Summary: This study investigated the effectiveness of interventions targeting treatable traits (TTs) for managing obstructive airway diseases (OADs). The meta-analyses showed that TT interventions were effective in improving health-related quality of life, reducing hospitalizations, decreasing all-cause-1-year mortality, alleviating dyspnea, anxiety, and depression in OADs.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

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Article Critical Care Medicine

Syndrome of Combined Pulmonary Fibrosis and Emphysema An Official ATS/ERS/JRS/ALAT Research Statement

Vincent Cottin et al.

Summary: This research summarizes the definition, characteristics, pathophysiology, and research priorities of combined pulmonary fibrosis and emphysema (CPFE). The research proposes CPFE to be recognized as a syndrome and offers classification criteria and descriptions of radiologic and pathological patterns.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

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Review Respiratory System

Recent advances in the management of systemic sclerosis-associated interstitial lung disease

Anna-Maria Hoffmann-Vold et al.

Summary: This review highlights recent advances in the diagnosis and treatment of interstitial lung disease associated with systemic sclerosis, including screening and early diagnosis, disease progression assessment and monitoring, and treatment approaches.

CURRENT OPINION IN PULMONARY MEDICINE (2022)

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Review Oncology

Novel clinical trial design and analytic methods to tackle challenges in therapeutic development in rare diseases

Yimei Li et al.

Summary: While only a fraction of the worldwide population may have a particular rare disorder, millions of people are affected by over 6,000 rare disorders without a safe and effective therapy. Challenges in developing therapies for rare disorders include difficulty in recruiting participants, lack of natural history data, and ethical issues in placebo arm randomization. This review discusses existing and novel strategies to address these challenges, emphasizing the importance of resource utilization, natural history studies, endpoint selection, and innovative clinical trial designs.

ANNALS OF TRANSLATIONAL MEDICINE (2022)

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Article Respiratory System

Developing a self-management package for pulmonary fibrosis: an international Delphi study

Joanna Y. T. Lee et al.

Summary: This study identified 12 essential components and highlighted the importance of individualization, goal setting, and feedback in self-management of pulmonary fibrosis (PF).

ERJ OPEN RESEARCH (2022)

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Article Respiratory System

Electronically monitored medication adherence in idiopathic pulmonary fibrosis: prevalence, predictors and outcomes

Anouk Delameillieure et al.

Summary: This study investigated medication adherence to pirfenidone in patients with idiopathic pulmonary fibrosis (IPF) using electronic monitoring. The findings revealed a high prevalence of nonadherence, which may negatively affect lung function. Further research is needed to understand the impact of nonadherence on outcomes and identify predictors, as well as develop tailored interventions.

ERJ OPEN RESEARCH (2022)

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Article Respiratory System

Impact of Concomitant Medication Burden on Tolerability of Disease-targeted Therapy and Survival in Interstitial Lung Disease

Yet H. Khor et al.

Summary: The study aimed to determine the associations between concomitant medication burden and tolerability of ILD-targeted medications and survival in patients with IPF and non-IPF ILD. The results showed that high baseline concomitant medication burden was associated with intolerance of ILD-targeted medications in patients with IPF, but this association was not observed in non-IPF ILD patients. The complexity of medication regimen was a better predictor of prognosis in ILD than a simple evaluation of concomitant medication burden.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2022)

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Review Respiratory System

Lung cancer in patients with fibrosing interstitial lung diseases: an overview of current knowledge and challenges

Namrata Kewalramani et al.

Summary: Patients with progressive fibrosing interstitial lung diseases (fILD) and lung cancer have a higher morbidity and mortality rate. The pathogenesis of both diseases is similar, but there are still unknown aspects. The combination of these two diseases presents a challenge due to the increased risk of mortality and the additional risks associated with lung cancer treatment in patients with underlying lung fibrosis. Therefore, it is crucial to carefully select treatment modalities to improve survival and maintain an acceptable quality of life. This overview provides a summary of the epidemiology, pathogenesis, treatment, and potential role of antifibrotic drugs in patients with lung cancer and fILD, and highlights the need for further research in this field.

ERJ OPEN RESEARCH (2022)

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Review Respiratory System

Antacid Medication and Antireflux Surgery in Patients with Idiopathic Pulmonary Fibrosis A Systematic Review and Meta-Analysis

Yet H. Khor et al.

Summary: There is currently insufficient evidence to support the use of antacid medication or antireflux surgery for improving respiratory outcomes in patients with IPF. Well-designed prospective studies with objective evaluation of GER are needed to determine the role of these interventions.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2022)

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Article Respiratory System

A Phase-2 Exploratory Randomized Controlled Trial of INOpulse in Patients with Fibrotic Interstitial Lung Disease Requiring Oxygen

Christopher S. King et al.

Summary: Treatment with INOpulse improves physical activity and symptoms in patients with interstitial lung disease requiring supplemental oxygen, with good tolerability.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2022)

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Article Respiratory System

Risk of cancer incidence in patients with idiopathic pulmonary fibrosis: A nationwide cohort study

Hong Yeul Lee et al.

Summary: IPF is associated with an increased risk for cancer incidence, especially lung cancer. Healthcare providers should be aware of this risk when treating patients with IPF.

RESPIROLOGY (2021)

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Article Medicine, General & Internal

Inhaled Treprostinil in Pulmonary Hypertension Due to Interstitial Lung Disease

Aaron Waxman et al.

Summary: In patients with pulmonary hypertension due to interstitial lung disease, inhaled treprostinil significantly improved exercise capacity and clinical outcomes compared to placebo in a 16-week trial. Adverse events such as cough, headache, dyspnea, dizziness, nausea, fatigue, and diarrhea were commonly reported.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Clinical Neurology

Interstitial lung disease and obstructive sleep apnea

Yet H. Khor et al.

Summary: Obstructive sleep apnea is a common comorbidity in patients with interstitial lung disease, and its significance in health outcomes is increasingly recognized. The relationship between ILD and OSA is complex and bidirectional, with multiple mechanisms potentially contributing to their pathogenic and physiologic links. This review synthesizes current evidence and hypotheses on the interactions between ILD and OSA, emphasizing the epidemiological, pathogenic, and pathophysiological aspects of their relationship.

SLEEP MEDICINE REVIEWS (2021)

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Article Critical Care Medicine

Characteristics and Prevalence of Domestic and Occupational Inhalational Exposures Across Interstitial Lung Diseases

Cathryn T. Lee et al.

Summary: The study found that most patients with various types of ILD had potentially relevant inhalational exposures. Exposures varied significantly based on demographics and were associated with worse transplant-free survival, but this survival difference was not significant after multivariable adjustment.

CHEST (2021)

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Article Respiratory System

Nutritional status and quality of life in interstitial lung disease: a prospective cohort study

Alisar A. Kanjrawi et al.

Summary: The study found that while a small number of ILD patients were malnourished, a large proportion of the cohort were overweight or obese. Handgrip strength was compromised and correlated to quality of life. Further research with a larger cohort is needed to explore the role of handgrip strength as a predictor of quality of life.

BMC PULMONARY MEDICINE (2021)

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Article Critical Care Medicine

Incidence and Prognostic Significance of Hypoxemia in Fibrotic Interstitial Lung Disease An International Cohort Study

Yet H. Khor et al.

Summary: Patients with idiopathic pulmonary fibrosis (IPF) have higher cumulative incidence of exertional and resting hypoxemia compared with patients without IPF. The extended ILD-GAP-O-2 model provides additional risk stratification for 1-year prognosis in patients with fibrotic ILD.

CHEST (2021)

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Review Pharmacology & Pharmacy

An updated safety review of the drug treatments for idiopathic pulmonary fibrosis

Giacomo Sgalla et al.

Summary: The approval of antifibrotic agents nintedanib and pirfenidone has revolutionized the management of idiopathic pulmonary fibrosis (IPF). While these treatments have shown acceptable tolerability in randomized-clinical trials, they are also associated with potential side effects that require careful assessment of risks and benefits in individual patients before and during antifibrotic therapy.

EXPERT OPINION ON DRUG SAFETY (2021)

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Review Respiratory System

Nocturnal hypoxaemia in interstitial lung disease: a systematic review

Yet Hong Khor et al.

Summary: Nocturnal hypoxaemia is common in ILD patients, associated with DLCO impairment and markers suggestive of pulmonary hypertension, and may be a potential prognostic factor in ILD patients.

THORAX (2021)

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Article Critical Care Medicine

Pirfenidone in patients with progressive fibrotic interstitial lung diseases other than idiopathic pulmonary fibrosis (RELIEF): a double-blind, randomised, placebo-controlled, phase 2b trial

Juergen Behr et al.

Summary: This multicentre, double-blind, randomised, placebo-controlled trial aimed to evaluate the efficacy and safety of pirfenidone in patients with progressive fibrotic interstitial lung diseases. Results after 48 weeks showed a significantly lower decline in FVC % predicted in the pirfenidone group compared to placebo, suggesting that adding pirfenidone to existing treatment might attenuate disease progression in these patients.

LANCET RESPIRATORY MEDICINE (2021)

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Review Respiratory System

Natural variability in the disease course of SSc-ILD: implications for treatment

Madelon C. Vonk et al.

Summary: Through longitudinal clinical trials and observational studies, researchers assessed definitions, progression patterns, risk factors, and implications for treatment of SSc-associated ILD. Approximately 20-30% of patients develop progressive ILD early in the disease course, with risk factors such as age, FVC, extent of fibrosis, and presence of anti-topoisomerase I antibodies contributing to predicting progression.

EUROPEAN RESPIRATORY REVIEW (2021)

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Review Respiratory System

Pulmonary hypertension in interstitial lung disease: screening, diagnosis and treatment

Juergen Behr et al.

Summary: The review discusses the challenges and recent advances in understanding the pathogenesis of pulmonary hypertension in the context of interstitial lung disease (PH-ILD). Recent findings from clinical trials on different drugs and treatments for PH-ILD are highlighted, providing an overview of the current status of screening, diagnosis, and management of pulmonary vascular disease in ILD patients.

CURRENT OPINION IN PULMONARY MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

2021 ESC Guidelines on cardiovascular disease prevention in clinical practice Developed by the Task Force for cardiovascular disease prevention in clinical practice with representatives of the European Society of Cardiology and 12 medical societies With the special contribution of the European Association of Preventive Cardiology (EAPC)

Frank L. J. Visseren et al.

EUROPEAN HEART JOURNAL (2021)

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Review Respiratory System

A contemporary practical approach to the multidisciplinary management of unclassifiable interstitial lung disease

Christopher J. Ryerson et al.

Summary: This review discusses the evaluation and management of patients with unclassifiable ILD, emphasizing the importance of accurate ILD diagnosis and the potential impact of specific features on management decisions. It highlights the increasing role of antifibrotic medications in fibrotic ILDs, while underscoring the ongoing relevance of immunomodulatory therapies for many patient populations. The review provides a practical approach for clinicians and calls for additional research to support a rational and standardized management approach for patients with unclassifiable ILD.

EUROPEAN RESPIRATORY JOURNAL (2021)

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Review Medicine, General & Internal

Treatment of fibrotic interstitial lung disease: current approaches and future directions

Kerri A. Johannson et al.

Summary: Fibrotic interstitial lung disease is a group of pulmonary disorders that are often progressive and associated with high morbidity and early mortality. Recent advancements have led to a better understanding and treatment of these diseases. Controversies and challenges exist, with evolving concepts being discussed as future research directions.

LANCET (2021)

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Article Cardiac & Cardiovascular Systems

Association between gastroprotective agents and risk of incident interstitial lung disease in systemic sclerosis

Raphael Hurtubise et al.

Summary: In this large retrospective cohort study, the use of gastroprotective or promotility agents was not associated with a reduced risk of development of clinically apparent SSc-ILD.

RESPIRATORY MEDICINE (2021)

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Review Respiratory System

Rheumatoid arthritis-interstitial lung disease: manifestations and current concepts in pathogenesis and management

Suha Kadura et al.

Summary: Rheumatoid arthritis (RA) is a systemic inflammatory disorder, with lung involvement being the most common extra-articular manifestation. RA-ILD is a leading cause of death in RA patients with significant morbidity and mortality. Rational clinical approaches for the diagnosis and management of RA-ILD are discussed, along with future directions for research in RA-associated lung disease.

EUROPEAN RESPIRATORY REVIEW (2021)

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Article Respiratory System

Pulmonary rehabilitation for interstitial lung disease: Referral and patient experiences

Mariana Hoffman et al.

Summary: The study found that 40% of ILD patients were referred to pulmonary rehabilitation, with higher referral rates in those with more severe disease. Limited patient knowledge about PR and various barriers were identified as issues that need to be addressed in improving PR participation among ILD patients.

CHRONIC RESPIRATORY DISEASE (2021)

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Article Respiratory System

Body mass index and in-hospital mortality in patients with acute exacerbation of idiopathic pulmonary fibrosis

Nobuyasu Awano et al.

Summary: The study found that among patients with AE-IPF, the underweight group had a higher mortality rate, while the obese group had a lower mortality rate.

ERJ OPEN RESEARCH (2021)

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Article Critical Care Medicine

Pirfenidone in patients with unclassifiable progressive fibrosing interstitial lung disease: a double-blind, randomised, placebo-controlled, phase 2 trial

Toby M. Maher et al.

LANCET RESPIRATORY MEDICINE (2020)

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Article Critical Care Medicine

A Randomized, Double-Blind, Placebo-Controlled Study of Pulsed, Inhaled Nitric Oxide in Subjects at Risk of Pulmonary Hypertension Associated With Pulmonary Fibrosis

Steven D. Nathan et al.

CHEST (2020)

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Article Respiratory System

Targeting treatable traits in severe asthma: a randomised controlled trial

Vanessa M. McDonald et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Article Cardiac & Cardiovascular Systems

Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction

Lorna Elise Clarson et al.

HEART (2020)

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Article Respiratory System

Peer Connect Service for people with pulmonary fibrosis in Australia: Participants' experiences and process evaluation

Gabriella Tikellis et al.

RESPIROLOGY (2020)

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Review Respiratory System

Pulmonary alveolar proteinosis

Stephane Jouneau et al.

RESPIROLOGY (2020)

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Editorial Material Respiratory System

Depression and anxiety in patients with interstitial lung disease

Abebaw Mengistu Yohannes

EXPERT REVIEW OF RESPIRATORY MEDICINE (2020)

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Review Respiratory System

The supportive care needs of people living with pulmonary fibrosis and their caregivers: a systematic review

Joanna Y. T. Lee et al.

EUROPEAN RESPIRATORY REVIEW (2020)

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Article Critical Care Medicine

Diagnosis of Hypersensitivity Pneumonitis in Adults An Official ATS/JRS/ALAT Clinical Practice Guideline

Ganesh Raghu et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Review Respiratory System

Obstructive sleep apnea in pulmonary fibrosis

Sophia E. Schiza et al.

CURRENT OPINION IN PULMONARY MEDICINE (2020)

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Article Respiratory System

Myositis-specific antibodies identify a distinct interstitial pneumonia with autoimmune features phenotype

Julia Graham et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Article Critical Care Medicine

Interstitial lung abnormalities detected incidentally on CT: a Position Paper from the Fleischner Society

Hiroto Hatabu et al.

LANCET RESPIRATORY MEDICINE (2020)

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Article Medicine, General & Internal

Inhaled Molgramostim Therapy in Autoimmune Pulmonary Alveolar Proteinosis

Bruce C. Trapnell et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Critical Care Medicine

Home Oxygen Therapy for Adults with Chronic Lung Disease An Official American Thoracic Society Clinical Practice Guideline

Susan S. Jacobs et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Article Respiratory System

Trends and seasonal variation of hospitalization and mortality of interstitial lung disease in the United States from 2006 to 2016

An Thi Nhat Ho et al.

RESPIRATORY RESEARCH (2020)

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Review Respiratory System

Reflux-Aspiration in Chronic Lung Disease

Augustine S. Lee et al.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2020)

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Review Medicine, General & Internal

Inflammatory Myopathy-Related Interstitial Lung Disease: From Pathophysiology to Treatment

Baptiste Hervier et al.

FRONTIERS IN MEDICINE (2020)

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Article Critical Care Medicine

Hypersensitivity Pneumonitis Radiologic Phenotypes Are Associated With Distinct Survival Time and Pulmonary Function Trajectory

Margaret L. Salisbury et al.

CHEST (2019)

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Article Cardiac & Cardiovascular Systems

2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

Donna K. Arnett et al.

CIRCULATION (2019)

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Review Respiratory System

Treatable traits: a new paradigm for 21st century management of chronic airway diseases: Treatable Traits Down Under International Workshop report

Vanessa M. McDonald et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

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Article Critical Care Medicine

Comprehensive Supportive Care for Patients with Fibrosing Interstitial Lung Disease

Marlies S. Wijsenbeek et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

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Article Medicine, General & Internal

Nintedanib in Progressive Fibrosing Interstitial Lung Diseases

K. R. Flaherty et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Article Medicine, General & Internal

Inhaled GM-CSF for Pulmonary Alveolar Proteinosis

Ryushi Tazawa et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Article Cardiac & Cardiovascular Systems

2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: Executive Summary

Scott M. Grundy et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

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Review Respiratory System

The natural history of progressive fibrosing interstitial lung diseases

Martin Kolb et al.

RESPIRATORY RESEARCH (2019)

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Article Respiratory System

Gaps in care of patients living with pulmonary fibrosis: a joint patient and expert statement on the results of a Europe-wide survey

Catharina C. Moor et al.

ERJ OPEN RESEARCH (2019)

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Article Critical Care Medicine

Treatment of Interstitial Lung Disease Associated Cough CHEST Guideline and Expert Panel Report

Surinder S. Birring et al.

CHEST (2018)

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Article Multidisciplinary Sciences

Patients' experiences of coping with Idiopathic Pulmonary Fibrosis and their recommendations for its clinical management

Sameera Senanayake et al.

PLOS ONE (2018)

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Letter Respiratory System

Weight loss as a predictor of mortality in patients with interstitial lung disease

Janelle Pugashetti et al.

EUROPEAN RESPIRATORY JOURNAL (2018)

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Article Critical Care Medicine

Effect of ambulatory oxygen on quality of life for patients with fibrotic lung disease (AmbOx): a prospective, open-label mixed-method, crossover randomised controlled trial

Dina Visca et al.

LANCET RESPIRATORY MEDICINE (2018)

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Review Medicine, General & Internal

Drug-Induced Interstitial Lung Disease: A Systematic Review

Sarah Skeoch et al.

JOURNAL OF CLINICAL MEDICINE (2018)

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Review Respiratory System

Risk factors for mortality and mortality rates in interstitial lung disease patients in the intensive care unit

Julio A. Huapaya et al.

EUROPEAN RESPIRATORY REVIEW (2018)

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Article Respiratory System

Fat-free mass index predicts survival in patients with idiopathic pulmonary fibrosis

Osamu Nishiyama et al.

RESPIROLOGY (2017)

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Article Respiratory System

Obstructive sleep apnoea and related comorbidities in incident idiopathic pulmonary fibrosis

Thomas Gille et al.

EUROPEAN RESPIRATORY JOURNAL (2017)

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Article Respiratory System

Functional and prognostic effects when emphysema complicates idiopathic pulmonary fibrosis

Joseph Jacob et al.

EUROPEAN RESPIRATORY JOURNAL (2017)

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Article Respiratory System

Precision medicine in airway diseases: moving to clinical practice

Alvar Agusti et al.

EUROPEAN RESPIRATORY JOURNAL (2017)

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Article Respiratory System

Towards an expert consensus to delineate a clinical syndrome of chronic breathlessness

Miriam J. Johnson et al.

EUROPEAN RESPIRATORY JOURNAL (2017)

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Letter Cardiac & Cardiovascular Systems

Longitudinal assessment of interstitial pneumonia with autoimmune features is encouraged

Sandra Chartrand et al.

RESPIRATORY MEDICINE (2017)

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Review Respiratory System

Comorbidities in interstitial lung diseases

George A. Margaritopoulos et al.

EUROPEAN RESPIRATORY REVIEW (2017)

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Review Critical Care Medicine

Acute Exacerbation of Idiopathic Pulmonary Fibrosis An International Working Group Report

Harold R. Collard et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2016)

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Article Radiology, Nuclear Medicine & Medical Imaging

Pulmonary Fibrosis on High-Resolution CT of Patients With Pulmonary Alveolar Proteinosis

Masanori Akira et al.

AMERICAN JOURNAL OF ROENTGENOLOGY (2016)

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Article Respiratory System

Treatable traits: toward precision medicine of chronic airway diseases

Alvar Agusti et al.

EUROPEAN RESPIRATORY JOURNAL (2016)

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Article Respiratory System

Clinical Correlates of Reduced Physical Activity in Idiopathic Pulmonary Fibrosis

Thomas Bahmer et al.

RESPIRATION (2016)

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Article Cardiac & Cardiovascular Systems

Predictors of survival in coexistent hypersensitivity pneumonitis with autoimmune features

Ayodeji Adegunsoye et al.

RESPIRATORY MEDICINE (2016)

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Article Respiratory System

Combined pulmonary fibrosis and emphysema: a retrospective analysis of clinical characteristics, treatment and prognosis

Lijuan Zhang et al.

BMC PULMONARY MEDICINE (2016)

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Article Critical Care Medicine

Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial

Donald P. Tashkin et al.

LANCET RESPIRATORY MEDICINE (2016)

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Article Multidisciplinary Sciences

Incidences and Risk Factors of Organ Manifestations in the Early Course of Systemic Sclerosis: A Longitudinal EUSTAR Study

Veronika K. Jaeger et al.

PLOS ONE (2016)

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Article Critical Care Medicine

An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline: Treatment of Idiopathic Pulmonary Fibrosis An Update of the 2011 Clinical Practice Guideline

Ganesh Raghu et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)

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Review Respiratory System

Comorbidities in idiopathic pulmonary fibrosis patients: a systematic literature review

Ganesh Raghu et al.

EUROPEAN RESPIRATORY JOURNAL (2015)

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Editorial Material Medicine, General & Internal

Precision Medicine - Personalized, Problematic, and Promising

J. Larry Jameson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

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Article Clinical Neurology

Obstructive sleep apnea should be treated in patients with idiopathic pulmonary fibrosis

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