Treatable traits: a comprehensive precision medicine approach in interstitial lung disease

Interstitial lung disease (ILD) is a diverse group of inflammatory and fibrotic lung conditions causing significant morbidity and mortality. A multitude of factors beyond the lungs influence symptoms, health-related quality of life, disease progression and survival in patients with ILD. Despite an increasing emphasis on multidisciplinary management in ILD, the absence of a framework for assessment and delivery of comprehensive patient care poses challenges in clinical practice. The treatable traits approach is a precision medicine care model that operates on the premise of individualised multidimensional assessment for distinct traits that can be targeted by specific interventions. The potential utility of this approach has been described in airway diseases, but has not been adequately considered in ILD. Given the similar disease heterogeneity and complexity between ILD and airway diseases, we explore the concept and potential application of the treatable traits approach in ILD. A framework of aetiological, pulmonary, extrapulmonary and behavioural and lifestyle treatable traits relevant to clinical care and outcomes for patients with ILD is proposed. We further describe key research directions to evaluate the application of the treatable traits approach towards advancing patient care and health outcomes in ILD.

Automated summary

Interstitial lung disease (ILD) is a diverse group of lung conditions that cause inflammation and fibrosis, resulting in significant morbidity and mortality. Beyond the lungs, various factors influence symptoms, quality of life, disease progression, and survival in ILD patients. This article explores the potential application of the treatable traits approach in ILD, which focuses on individualized assessment and targeted interventions for specific traits. The authors propose a framework of treatable traits in ILD and suggest key research directions for advancing patient care and health outcomes.