4.6 Article

Comparing species-different responses in pulmonary fibrosis research: Current understanding of in vitro lung cell models and nanomaterials

Related references

Note: Only part of the references are listed.
Article Immunology

B Cells Are Not Involved in the Regulation of Adenoviral TGF-β1-or Bleomycin-Induced Lung Fibrosis in Mice

Marie T. Moog et al.

Summary: Research has found accumulations of B cells in patients with pulmonary fibrosis as well as in experimental animal models. However, comparative analysis between wild-type mice and B cell-deficient mice does not support a significant involvement of B cells in mouse lung fibrogenesis.

JOURNAL OF IMMUNOLOGY (2022)

Article Nanoscience & Nanotechnology

AOP173 key event associated pathway predictor - online application for the prediction of benchmark dose lower bound (BMDLs) of a transcriptomic pathway involved in MWCNTs-induced lung fibrosis

Maciej Gromelski et al.

Summary: Nano-QSAR models can predict the toxicity of untested materials by linking their structural properties with biological responses. However, these models are often not used due to complexity and limited accessibility. This paper encourages the development of user-friendly applications based on predictive models to promote wider adoption.

NANOTOXICOLOGY (2022)

Review Immunology

Extracellular vesicles in idiopathic pulmonary fibrosis: pathogenesis and therapeutics

Yu Fujita

Summary: Idiopathic pulmonary fibrosis is a progressive lung disease with limited therapeutic options. Extracellular vesicles (EVs) have been extensively studied in the pathogenesis and treatment of IPF, showing potential therapeutic value.

INFLAMMATION AND REGENERATION (2022)

Article Chemistry, Multidisciplinary

Interleukin-1 beta released from macrophages stimulated with indium tin oxide nanoparticles induces epithelial-mesenchymal transition in A549 cells

Yosuke Tabei et al.

Summary: This study found that ITO nanoparticles can induce epithelial-mesenchymal transition (EMT) progression by stimulating the production of interleukin-1 beta (IL-1 beta) from co-cultured macrophages. These findings contribute to our understanding of the effects of ITO on cellular behavior and provide a new mechanistic explanation for the development of pulmonary fibrosis.

ENVIRONMENTAL SCIENCE-NANO (2022)

Article Nanoscience & Nanotechnology

A methodology for developing key events to advance nanomaterial-relevant adverse outcome pathways to inform risk assessment

Sabina Halappanavar et al.

Summary: Significant progress has been made in the development of Adverse Outcome Pathways (AOPs) focusing on the toxicity mechanisms of chemicals, but there is a lack of consideration for the size-associated properties of manufactured nanomaterials (MNs) in current AOPs. By utilizing existing nanotoxicology literature, this study established a systematic methodology for identifying key events (KEs) relevant to MNs and addressed the limitations and opportunities in the field. Recommendations were provided for future reporting of nanotoxicology results to expedite the development of AOPs for MNs and aid in regulatory decision making.

NANOTOXICOLOGY (2021)

Review Medicine, Research & Experimental

Gene therapy strategies for idiopathic pulmonary fibrosis: recent advances, current challenges, and future directions

Mitchel J. R. Ruigrok et al.

Summary: Idiopathic pulmonary fibrosis (IPF) is a chronic disease with no current cure, necessitating the exploration of more effective treatments such as gene therapy. While gene therapy shows promise in addressing the underlying mechanisms of fibrosis, further research is needed to evaluate its potential for clinical application.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2021)

Article Environmental Sciences

Nanomaterials induce different levels of oxidative stress, depending on the used model system: Comparison of in vitro and in vivo effects

Isabel Karkossa et al.

Summary: The study compared the effects of NMs in vitro and in vivo, and found that the MoAs of NMs depend on the model system used. In vivo, pathways related to inflammation were more affected than oxidative stress responses. However, the overall classification of active and passive NMs was consistent in vitro and in vivo.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Chemistry, Multidisciplinary

The Use of Nanomaterial In Vivo Organ Burden Data for In Vitro Dose Setting

Lan Ma-Hock et al.

Summary: When studying the effects of nanomaterials, it is important to consider the differences between in vitro and in vivo models. The use of IVIVE procedures can help reduce exposure differences and improve research outcomes.

SMALL (2021)

Review Chemistry, Multidisciplinary

Non-Animal Strategies for Toxicity Assessment of Nanoscale Materials: Role of Adverse Outcome Pathways in the Selection of Endpoints

Sabina Halappanavar et al.

Summary: Faster, cheaper, more sensitive, and mechanisms-based animal alternatives are needed for safety assessment of nanomaterials, along with strategies to identify and prioritize alternative schemes and enable their validation and refinement. This review presents two strategies, the current nanotoxicology literature review and the adverse outcome pathways (AOPs) framework, to address these needs. Through analyzing frequently assessed toxicity measurements, AOPs of relevance to inhalation toxicity of NM, and specific AOPs for lung fibrosis, key events of toxicity for in vitro assay development are identified.

SMALL (2021)

Article Environmental Sciences

Silica dust exposure induces pulmonary fibrosis through autophagy signaling

Ning Li et al.

Summary: Silicosis is a well-recognized occupational lung disease caused by inhalation of free silica dust, leading to a negative impact on patients' quality of life. Autophagy plays a critical role in the development of pulmonary fibrosis and may affect fibrosis progression through regulating inflammatory response. In vivo and in vitro experiments showed that autophagy signaling pathway, especially PI3K/Akt/mTOR, is involved in the pathogenesis of silicosis-induced pulmonary fibrosis, and NAC could alleviate inflammatory response through a non PI3K/Akt/mTOR pathway.

ENVIRONMENTAL TOXICOLOGY (2021)

Review Medicine, General & Internal

Human-Based Advanced in vitro Approaches to Investigate Lung Fibrosis and Pulmonary Effects of COVID-19

Mirjam Kiener et al.

Summary: The COVID-19 pandemic has led to concerns about disease recovery and long-term pulmonary damage, with infection potentially leading to diffuse alveolar damage and fibrotic remodeling progressing towards pulmonary fibrosis. The precise causes and mechanisms of lung fibrosis remain poorly understood, but advancements in lung models have allowed for a deeper investigation into SARS-CoV-2 infection and alveolar tissue regeneration.

FRONTIERS IN MEDICINE (2021)

Article Cell Biology

LncRNA-ATB regulates epithelial-mesenchymal transition progression in pulmonary fibrosis via sponging miR-29b-2-5p and miR-34c-3p

Qi Xu et al.

Summary: The dysregulation of non-coding RNAs, particularly lncRNA-ATB and its downstream targets miR-29b-2-5p and miR-34c-3p, plays a crucial role in regulating EMT and fibrosis in pulmonary diseases. Overexpression of miR-29b-2-5p or miR-34c-3p can inhibit EMT progression and counteract the pro-fibrotic effects of lncRNA-ATB, providing potential therapeutic targets for pulmonary fibrosis.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Article Respiratory System

Patient gender bias on the diagnosis of idiopathic pulmonary fibrosis

Deborah Assayag et al.

THORAX (2020)

Review Biotechnology & Applied Microbiology

Bioengineered 3D Models to Recapitulate Tissue Fibrosis

Marta Sacchi et al.

TRENDS IN BIOTECHNOLOGY (2020)

Article Chemistry, Multidisciplinary

Use of EpiAlveolar Lung Model to Predict Fibrotic Potential of Multiwalled Carbon Nanotubes

Hana Barosova et al.

ACS NANO (2020)

Article Physiology

Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis

Seok-Jo Kim et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2020)

Review Pharmacology & Pharmacy

Current models of pulmonary fibrosis for future drug discovery efforts

Toyoshi Yanagihara et al.

EXPERT OPINION ON DRUG DISCOVERY (2020)

Review Environmental Sciences

New Approach Methods to Evaluate Health Risks of Air Pollutants: Critical Design Considerations for In Vitro Exposure Testing

Jose Zavala et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2020)

Article Biochemistry & Molecular Biology

An In Vitro Lung System to Assess the Proinflammatory Hazard of Carbon Nanotube Aerosols

Hana Barosova et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biotechnology & Applied Microbiology

In vitroAlternatives to Acute Inhalation Toxicity Studies in Animal Models-A Perspective

Dania Movia et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Article Public, Environmental & Occupational Health

Lung cancer mortality in the French cohort of titanium dioxide workers: some aetiological insights

Irina Guseva Canu et al.

OCCUPATIONAL AND ENVIRONMENTAL MEDICINE (2020)

Article Physiology

A Novel Fibroblast Reporter Cell Line for in vitro Studies of Pulmonary Fibrosis

Julia Nemeth et al.

FRONTIERS IN PHYSIOLOGY (2020)

Article Environmental Sciences

TGF-β1 mediated MAPK signaling pathway promotes collagen formation induced by Nano NiO in A549 cells

Minmin Tian et al.

ENVIRONMENTAL TOXICOLOGY (2019)

Review Medicine, General & Internal

Epithelial-Mesenchymal Transition in the Pathogenesis of Idiopathic Pulmonary Fibrosis

Francesco Salton et al.

MEDICINA-LITHUANIA (2019)

Article Dermatology

In Vivo Models for the Study of Fibrosis

Jagannath Padnnanabhan et al.

ADVANCES IN WOUND CARE (2019)

Article Critical Care Medicine

The Transferrin Receptor CD71 Delineates Functionally Distinct Airway Macrophage Subsets during Idiopathic Pulmonary Fibrosis

Sarah J. Allden et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

Article Biochemistry & Molecular Biology

Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage

Stefan Uderhardt et al.

Article Toxicology

A novel human 3D lung microtissue model for nanoparticle-induced cell-matrix alterations

Pranita K. Kabadi et al.

PARTICLE AND FIBRE TOXICOLOGY (2019)

Review Medical Laboratory Technology

3D bioprinting for lungs and hollow organs

Zachary Galliger et al.

TRANSLATIONAL RESEARCH (2019)

Review Cell Biology

Nano-bio interactions: a neutrophil-centric view

Sandeep Keshavan et al.

CELL DEATH & DISEASE (2019)

Article Respiratory System

Gender differences at presentation of idiopathic pulmonary fibrosis in Sweden

Dimitrios Kalafatis et al.

BMC PULMONARY MEDICINE (2019)

Article Critical Care Medicine

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

Paul A. Reyfman et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

Article Biochemistry & Molecular Biology

Long-term expanding human airway organoids for disease modeling

Norman Sachs et al.

EMBO JOURNAL (2019)

Article Biotechnology & Applied Microbiology

Impaired Wound Healing of Alveolar Lung Epithelial Cells in a Breathing Lung-On-A-Chip

Marcel Felder et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

Review Nanoscience & Nanotechnology

Mechanisms of carbon nanotube-induced pulmonary fibrosis: a physicochemical characteristic perspective

Katherine S. Duke et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2018)

Review Pharmacology & Pharmacy

3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling

Xuanyi Ma et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

Article Biochemistry & Molecular Biology

High levels of IL-6 and IL-8 characterize early-on idiopathic pulmonary fibrosis acute exacerbations

Spyros A. Papiris et al.

CYTOKINE (2018)

Article Respiratory System

Optimising experimental research in respiratory diseases: an ERS statement

Philippe Bonniaud et al.

EUROPEAN RESPIRATORY JOURNAL (2018)

Article Critical Care Medicine

Increased Extracellular Vesicles Mediate WNT5A Signaling in Idiopathic Pulmonary Fibrosis

Aina Martin-Medina et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

Article Multidisciplinary Sciences

Medium throughput breathing human primary cell alveolus-on-chip model

Janick D. Stucki et al.

SCIENTIFIC REPORTS (2018)

Review Engineering, Biomedical

3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances

Soroosh Derakhshanfar et al.

BIOACTIVE MATERIALS (2018)

Article Respiratory System

Toxic and Genomic Influences of Inhaled Nanomaterials as a Basis for Predicting Adverse Outcome

Penny Nymark et al.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2018)

Article Respiratory System

Acellular human lung scaffolds to mode lung disease and tissue regeneration

Sarah E. Gilpin et al.

EUROPEAN RESPIRATORY REVIEW (2018)

Article Cell & Tissue Engineering

Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling

Dan C. Wilkinson et al.

STEM CELLS TRANSLATIONAL MEDICINE (2017)

Review Biotechnology & Applied Microbiology

Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease

Ana L. Mora et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Article Pharmacology & Pharmacy

Olodaterol shows anti-fibrotic efficacy in in vitro and in vivo models of pulmonary fibrosis

Franziska Elena Herrmann et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

Review Environmental Sciences

In vitro approaches to assess the hazard of nanomaterials

Barbara Drasler et al.

NANOIMPACT (2017)

Review Medicine, General & Internal

Exploring Animal Models That Resemble Idiopathic Pulmonary Fibrosis

Jun Tashiro et al.

FRONTIERS IN MEDICINE (2017)

Article Physiology

An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices

Hani N. Alsafadi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2017)

Article Biochemistry & Molecular Biology

An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis

R. Gisli Jenkins et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2017)

Article Environmental Sciences

Secreted Phosphoprotein 1 and Sex-Specific Differences in Silica-Induced Pulmonary Fibrosis in Mice

Joseph D. Latoche et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2016)

Review Immunology

Macrophages in Tissue Repair, Regeneration, and Fibrosis

Thomas A. Wynn et al.

IMMUNITY (2016)

Article Environmental Sciences

Multiwalled carbon nanotube-induced pulmonary inflammatory and fibrotic responses and genomic changes following aspiration exposure in mice: A 1-year postexposure study

Brandi N. Snyder-Talkington et al.

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES (2016)

Review Toxicology

Myofibroblasts and lung fibrosis induced by carbon nanotube exposure

Jie Dong et al.

PARTICLE AND FIBRE TOXICOLOGY (2016)

Article Pharmacology & Pharmacy

Fibrosis biomarkers in workers exposed to MWCNTs

Liliya M. Fatkhutdinova et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)

Review Biochemistry & Molecular Biology

Pulmonary Macrophages: A New Therapeutic Pathway in Fibrosing Lung Disease?

Adam J. Byrne et al.

TRENDS IN MOLECULAR MEDICINE (2016)

Article Multidisciplinary Sciences

Mesenchymal stem cells are sensitive to bleomycin treatment

Nils H. Nicolay et al.

SCIENTIFIC REPORTS (2016)

Article Physiology

Identification of TGF-β receptor-1 as a key regulator of carbon nanotube-induced fibrogenesis

Anurag Mishra et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2015)

Article Physiology

Multidimensional immunolabeling and 4D time-lapse imaging of vital ex vivo lung tissue

Gerald Burgstaller et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2015)

Article Biochemistry & Molecular Biology

Modeling Pulmonary Disease Pathways Using Recombinant Adeno-Associated Virus 6.2

Benjamin Strobel et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2015)

Review Biochemistry & Molecular Biology

The cytokines of pulmonary fibrosis: Much learned, much more to learn

Irina G. Luzina et al.

CYTOKINE (2015)

Review Respiratory System

Comorbidities in idiopathic pulmonary fibrosis patients: a systematic literature review

Ganesh Raghu et al.

EUROPEAN RESPIRATORY JOURNAL (2015)

Article Cell Biology

Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis

Alyssa D. Gregory et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2015)

Review Nanoscience & Nanotechnology

Advances in mechanisms and signaling pathways of carbon nanotube toxicity

Jie Dong et al.

NANOTOXICOLOGY (2015)

Review Pharmacology & Pharmacy

Bleomycin in the setting of lung fibrosis induction: From biological mechanisms to counteractions

Veronica Della Latta et al.

PHARMACOLOGICAL RESEARCH (2015)

Article Materials Science, Biomaterials

In vitro model alveoli from photodegradable microsphere templates

Katherine J. R. Lewis et al.

BIOMATERIALS SCIENCE (2015)

Article Multidisciplinary Sciences

Engineering an in vitro air-blood barrier by 3D bioprinting

Lenke Horvath et al.

SCIENTIFIC REPORTS (2015)

Article Medicine, Research & Experimental

Toward the Replacement of Animal Experiments through the Bioinformatics-driven Analysis of 'Omics' Data from Human Cell Cultures

Roland C. Grafstrom et al.

ATLA-ALTERNATIVES TO LABORATORY ANIMALS (2015)

Review Pharmacology & Pharmacy

Carrier interactions with the biological barriers of the lung: Advanced in vitro models and challenges for pulmonary drug delivery

Cristiane de Souza Carvalho et al.

ADVANCED DRUG DELIVERY REVIEWS (2014)

Article Biotechnology & Applied Microbiology

Efficient generation of lung and airway epithelial cells from human pluripotent stem cells

Sarah X. L. Huang et al.

NATURE BIOTECHNOLOGY (2014)

Article Medicine, Research & Experimental

State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology

Natalie Alépée

ALTEX-Alternatives to Animal Experimentation (2014)

Review Immunology

Liver fibrosis and repair: immune regulation of wound healing in a solid organ

Antonella Pellicoro et al.

NATURE REVIEWS IMMUNOLOGY (2014)

Review Immunology

Alveolar macrophages: plasticity in a tissue-specific context

Tracy Hussell et al.

NATURE REVIEWS IMMUNOLOGY (2014)

Review Pharmacology & Pharmacy

Pulmonary toxicity of carbon nanotubes and asbestos - Similarities and differences

Ken Donaldson et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

Review Biochemistry & Molecular Biology

Animal Models of Fibrotic Lung Disease

Bethany B. Moore et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)

Article Cardiac & Cardiovascular Systems

Decellularization of Human and Porcine Lung Tissues for Pulmonary Tissue Engineering

John D. O'Neill et al.

ANNALS OF THORACIC SURGERY (2013)

Review Biochemistry & Molecular Biology

Fibrosis of two: Epithelial cell-fibroblast interactions in pulmonary fibrosis

Norihiko Sakai et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2013)

Review Biochemistry & Molecular Biology

Cytokine mediated tissue fibrosis

Lee A. Borthwick et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2013)

Article Environmental Sciences

Interlaboratory Evaluation of Rodent Pulmonary Responses to Engineered Nanomaterials: The NIEHS Nano GO Consortium

James C. Bonner et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2013)

Article Genetics & Heredity

Functionalized single-walled carbon nanotubes cause reversible acute lung injury and induce fibrosis in mice

Yanli Zhang et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2013)

Article Toxicology

Distribution and fibrotic response following inhalation exposure to multi-walled carbon nanotubes

Robert R. Mercer et al.

PARTICLE AND FIBRE TOXICOLOGY (2013)

Review Pharmacology & Pharmacy

The adverse outcome pathway concept: A pragmatic tool in toxicology

Mathieu Vinken

TOXICOLOGY (2013)

Review Respiratory System

Fibrocytes in pulmonary fibrosis: a brief synopsis

Shyam Maharaj et al.

EUROPEAN RESPIRATORY REVIEW (2013)

Article Critical Care Medicine

Acellular Normal and Fibrotic Human Lung Matrices as a Culture System for In Vitro Investigation

Adam J. Booth et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2012)

Review Oncology

MicroRNA control of epithelial-mesenchymal transition and metastasis

Jinsong Zhang et al.

CANCER AND METASTASIS REVIEWS (2012)

Editorial Material Allergy

A Silica-Induced Pulmonary Fibrosis Model: Are We Closer to 'Real Life'?

E. Fireman

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2012)

Review Medicine, Research & Experimental

Pulmonary fibrosis: patterns and Perpetrators

Paul W. Noble et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Nanoscience & Nanotechnology

Assessment of Pulmonary Fibrogenic Potential of Multiwalled Carbon Nanotubes in Human Lung Cells

Anurag Mishra et al.

JOURNAL OF NANOMATERIALS (2012)

Article Medicine, General & Internal

Silicosis

Chi Chiu Leung et al.

LANCET (2012)

Article Biotechnology & Applied Microbiology

miR-29 Inhibits Bleomycin-induced Pulmonary Fibrosis in Mice

Jun Xiao et al.

MOLECULAR THERAPY (2012)

Article Nanoscience & Nanotechnology

Epithelial-mesenchymal transition contributes to SWCNT-induced pulmonary fibrosis

Chih-Ching Chang et al.

NANOTOXICOLOGY (2012)

Review Biochemistry & Molecular Biology

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

Thomas A. Wynn et al.

NATURE MEDICINE (2012)

Article Cardiac & Cardiovascular Systems

Lung capillary blood volume and membrane diffusion in idiopathic interstitial pneumonia

Lidwine Wemeau-Stervinou et al.

RESPIRATORY MEDICINE (2012)

Review Pharmacology & Pharmacy

Mechanisms of carbon nanotube-induced toxicity: Focus on oxidative stress

Anna A. Shvedova et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2012)

Review Cell Biology

Molecular and cellular mechanisms of pulmonary fibrosis

Nevins W. Todd et al.

FIBROGENESIS & TISSUE REPAIR (2012)

Article Medicine, General & Internal

Progress Toward Improving Animal Models for Idiopathic Pulmonary Fibrosis

Amber L. Degryse et al.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2011)

Article Respiratory System

Modeling pulmonary fibrosis with bleomycin

Marios A. Mouratis et al.

CURRENT OPINION IN PULMONARY MEDICINE (2011)

Article Medicine, Research & Experimental

Carbon black nanoparticles enhance bleomycin-induced lung inflammatory and fibrotic changes in mice

Hirofumi Kamata et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2011)

Review Immunology

Integrating mechanisms of pulmonary fibrosis

Thomas A. Wynn

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

Review Biotechnology & Applied Microbiology

Imaging methods for determining uptake and toxicity of carbon nanotubes in vitro and in vivo

Hannah C. Nerl et al.

NANOMEDICINE (2011)

Editorial Material Medicine, General & Internal

Resolving the Scar of Pulmonary Fibrosis

Gregory P. Downey

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Toxicology

Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes

Robert R. Mercer et al.

PARTICLE AND FIBRE TOXICOLOGY (2011)

Article Nanoscience & Nanotechnology

Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation

Valerian E. Kagan et al.

NATURE NANOTECHNOLOGY (2010)

Review Toxicology

The nanosilica hazard: another variable entity

Dorota Napierska et al.

PARTICLE AND FIBRE TOXICOLOGY (2010)

Review Pharmacology & Pharmacy

Human primary bronchial lung cell constructs: The new respiratory models

Kelly BeruBe et al.

TOXICOLOGY (2010)

Article Physiology

Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis

Shubha Murthy et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2009)

Article Critical Care Medicine

Global Impairment of CD4+CD25+FOXP3+ Regulatory T Cells in Idiopathic Pulmonary Fibrosis

Ioannis Kotsianidis et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009)

Review Medicine, Research & Experimental

The basics of epithelial-mesenchymal transition

Raghu Kalluri et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

Review Immunology

Pulmonary fibrosis: pathogenesis, etiology and regulation

M. S. Wilson et al.

MUCOSAL IMMUNOLOGY (2009)

Article Nanoscience & Nanotechnology

Inhaled carbon nanotubes reach the subpleural tissue in mice

Jessica P. Ryman-Rasmussen et al.

NATURE NANOTECHNOLOGY (2009)

Review Immunology

Cracking the BAFF code

Fabienne Mackay et al.

NATURE REVIEWS IMMUNOLOGY (2009)

Review Physiology

Murine models of pulmonary fibrosis

Bethany B. Moore et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2008)

Article Critical Care Medicine

Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis

Marjukka Myllarniemi et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2008)

Article Critical Care Medicine

Telomere shortening in familial and sporadic pulmonary fibrosis

Jennifer T. Cronkhite et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2008)

Review Oncology

Cellular and molecular mechanisms of fibrosis

T. A. Wynn

JOURNAL OF PATHOLOGY (2008)

Review Endocrinology & Metabolism

It's all about sex: gender, lung development and lung disease

Michelle A. Carey et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2007)

Article Biochemistry & Molecular Biology

Endothelin-1 induces alveolar epithelial-mesenchymal transition through endothelin type a receptor-mediated production of TGF-β1

Raksha Jain et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2007)

Review Allergy

New developments in the understanding of immunology in silicosis

Francois Huaux

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2007)

Article Critical Care Medicine

A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via CCL18

A Prasse et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2006)

Article Physiology

Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice

AA Shvedova et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2005)

Article Pharmacology & Pharmacy

Respiratory toxicity of multi-wall carbon nanotubes

J Muller et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2005)

Review Biochemistry & Molecular Biology

Pulmonary fibrosis - Searching for model answers

F Chua et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2005)

Article Physiology

PPARγ agonists inhibit TGF-β induced pulmonary myofibroblast differentiation and collagen production:: implications for therapy of lung fibrosis

HA Burgess et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2005)

Article Multidisciplinary Sciences

A critical role for eosinophils in allergic airways remodeling

AA Humbles et al.

SCIENCE (2004)

Article Biochemistry & Molecular Biology

Wound healing: An overview of acute, fibrotic and delayed healing

RF Diegelmann et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2004)

Article Immunology

Therapeutic targeting of IL-4- and IL-13-responsive cells in pulmonary fibrosis

C Jakubzick et al.

IMMUNOLOGIC RESEARCH (2004)

Review Biochemistry & Molecular Biology

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis

B Fubini et al.

FREE RADICAL BIOLOGY AND MEDICINE (2003)

Article Nutrition & Dietetics

Dietary iron is associated with bone mineral density in healthy postmenopausal women

MM Harris et al.

JOURNAL OF NUTRITION (2003)

Article Biochemistry & Molecular Biology

Differences in the fibrogenic response after transfer of active transforming growth factor-β1 gene to lungs of fibrosis-prone and fibrosis-resistant mouse strains

M Kolb et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2002)

Article Physiology

IL-12 attenuates bleomycin-induced pulmonary fibrosis

MP Keane et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2001)

Article Biochemistry & Molecular Biology

Bronchial epithelial cell matrix production in response to silica and basic fibroblast growth factor

M Bodo et al.

MOLECULAR MEDICINE (2001)