4.6 Article

Mucoadhesive 3D printed vaginal ovules to treat endometriosis and fibrotic uterine diseases

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

Endometriosis, the Silent Disease: Molecular Targets, Active Principles, and Drug Delivery Systems

Sarah Teworte et al.

Summary: This article provides a comprehensive overview of the pathophysiological processes involved in endometriosis, highlighting the role of inflammation, fibrosis, angiogenesis, hormonal regulation, and genetic factors. It also emphasizes the importance of drug delivery in the treatment of this disease.

HELVETICA CHIMICA ACTA (2023)

Review Physiology

Uterine Fibroids: Hiding in Plain Sight

Elizabeth A. Stewart et al.

Summary: Uterine fibroids are a common condition in women that can cause serious health issues. The mechanisms behind their growth and development are currently not well understood and require further research.

PHYSIOLOGY (2022)

Article Pharmacology & Pharmacy

Women’s preferences and acceptance for different drug delivery routes and products

Rita Palmeira-de-Oliveira et al.

ADVANCED DRUG DELIVERY REVIEWS (2022)

Article Chemistry, Multidisciplinary

How agarose gels surrounding PLGA implants limit swelling and slow down drug release

C. Bassand et al.

Summary: The aim of this study was to investigate the influence of an agarose gel on the drug release kinetics of a PLGA implant. The presence of the gel was found to delay the onset of the second release phase of the drug, possibly due to the steric hindrance of implant swelling. These findings highlight the importance of PLGA swelling in controlling drug release.

JOURNAL OF CONTROLLED RELEASE (2022)

Review Pharmacology & Pharmacy

Advances and future perspectives in epithelial drug delivery

Yousuf Mohammed et al.

Summary: Epithelial surfaces play a crucial role in protecting the body from foreign materials and can be utilized for drug delivery. The permeability of different epithelia varies based on their exposure and function. Advancements in epithelial drug delivery systems have been driven by quality-by-design approach and the growth of generic products.

ADVANCED DRUG DELIVERY REVIEWS (2022)

Review Pharmacology & Pharmacy

In vitro and ex vivo models for evaluating vaginal drug delivery systems

Rachel L. Shapiro et al.

Summary: Vaginal drug delivery systems are preferred for treating female reproductive tract diseases with fewer systemic side effects, but face anatomical and biological barriers. In vitro and ex vivo models are crucial for evaluating these systems. Advanced model systems for other mucosa can inspire future development for the female reproductive tract.

ADVANCED DRUG DELIVERY REVIEWS (2022)

Review Pharmacology & Pharmacy

Additive manufacturing in drug delivery: Innovative drug product design and opportunities for industrial application

Heloise Ragelle et al.

Summary: Additive manufacturing or 3D printing is revolutionizing product design, with significant impact and opportunities in drug delivery. AM offers unconventional release, customization, and miniaturization features for various applications in drug product fabrication.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Review Pharmacology & Pharmacy

Drug delivery strategies for management of women's health issues in the upper genital tract

Sravan Kumar Patel et al.

Summary: This review provides an overview of the anatomy, physiology, and mucosal properties of the female upper genital tract (UGT), highlighting the challenges in disease management and opportunities for new technologies to target the UGT.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Article Pharmacology & Pharmacy

3D printed estradiol-eluting urogynecological mesh implants: Influence of material and mesh geometry on their mechanical properties

Zara-Louise Farmer et al.

Summary: This study investigated the use of thermoplastic polyurethane (TPU) as an alternative material for surgical mesh implants instead of polypropylene (PP), and hormone-loaded meshes were produced using fused deposition modelling. The results showed that TPU meshes were more suitable for pelvic floor repair than PP, and 3D printed meshes exhibited linear release of 17-beta-estradiol (E2) over a two weeks period.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Review Biochemistry & Molecular Biology

Controlled Drug Delivery Systems: Current Status and Future Directions

Shivakalyani Adepu et al.

Summary: The paper discusses the evolution of drug delivery systems, the limitations of conventional drug delivery, and the details of controlled drug delivery systems, including design considerations, classifications, and recent research findings on nano-drug delivery, targeted drug delivery, and smart drug delivery using intelligent biomaterials. The challenges and future directions in controlled drug delivery are also addressed in the conclusion.

MOLECULES (2021)

Article Multidisciplinary Sciences

Hexavalent sperm-binding IgG antibody released from vaginal film for development of potent on-demand nonhormonal female contraception

Bhawana Shrestha et al.

Summary: The study developed a hexavalent antibody FIF with ultrapotent sperm-binding ability and formulated it into a water-soluble contraceptive film, which successfully reduced the number of motile sperm in sheep vagina. This research supports the potential of multivalent contraceptive antibodies for safe, effective, on-demand nonhormonal contraception.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Multidisciplinary Sciences

Collagen I triggers directional migration, invasion and matrix remodeling of stroma cells in a 3D spheroid model of endometriosis

Anna Stejskalova et al.

Summary: This study utilized endometrial spheroids to mimic the architecture of the endometrium and found that stromal spheroids exhibited coordinated directional migration on collagen I, resembling ectopic lesions. The spheroid assay proves to be a useful pre-clinical tool for evaluating potential treatments for endometriosis, including small molecule drugs and microRNA-based therapeutics.

SCIENTIFIC REPORTS (2021)

Article Medicine, General & Internal

Safety, acceptability, and pharmacokinetics of a monoclonal antibody-based vaginal multipurpose prevention film (MB66): A Phase I randomized trial

Joseph A. Politch et al.

Summary: MB66 film, a MPT product with monoclonal antibodies, was shown to be safe, well tolerated, and effective in protecting the vaginal environment for at least 24 hours. The levels and bioactivity of antibodies in vaginal secretions were consistent with protection.

PLOS MEDICINE (2021)

Article Multidisciplinary Sciences

Design aspects of vaginal applicators that influence acceptance among target users

Alyssa J. Bakke et al.

Summary: Research indicates that physical applicator attributes appealing to women include color, visual appeal, ease of grip, expected ease of use, and expected comfort inside the body. Women typically prefer plastic tampon applicators, which also tend to contain more positive features compared to other types of applicators.

SCIENTIFIC REPORTS (2021)

Review Pharmacology & Pharmacy

Mucosal drug delivery and 3D printing technologies: A focus on special patient populations

Christina Karavasili et al.

Summary: Additive manufacturing technologies have revolutionized healthcare provision by addressing personalized needs in large patient groups, particularly sensitive subgroups. These technologies also play a crucial role in overcoming health challenges by developing new drug delivery systems with competitive advantages and focusing on sensitive patient populations.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Review Pharmacology & Pharmacy

Vaginal drug delivery approaches for localized management of cervical cancer

Xue Wang et al.

Summary: Traditional methods for treating cervical cancer may have complications, leading to interest in new pharmaceutical forms based on nanotechnology. Vaginal drug delivery, with advantages like mucosa penetration and controlled drug release, is becoming a focus for the treatment of cervical cancer.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Article Multidisciplinary Sciences

Pirfenidone modifies hepatic miRNAs expression in a model of MAFLD/NASH

Rebeca Escutia-Gutierrez et al.

Summary: The study found that PR-PFD can reduce the expression levels of miRNAs in MAFLD/NASH animals, decrease the expression of genes involved in inflammation and lipid metabolism, and reverse the expression of genes affecting cholesterol synthesis and inflammatory response.

SCIENTIFIC REPORTS (2021)

Review Biochemistry & Molecular Biology

Endometriosis: Etiology, pathobiology, and therapeutic prospects

Philippa T. K. Saunders et al.

Summary: Endometriosis is a common condition associated with infertility that causes chronic pain in women. The exact cause and natural history are still uncertain, but hormonal, neurological, and immunological factors are believed to play a role in the development of symptoms. Current interventions have limited efficacy with high rates of symptom recurrence.
Review Obstetrics & Gynecology

Cellular Components Contributing to Fibrosis in Endometriosis: A Literature Review

Paola Vigano et al.

JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY (2020)

Review Medicine, General & Internal

Endometriosis

Krina T. Zondervan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Multidisciplinary Sciences

Fibrosis: from mechanisms to medicines

Neil C. Henderson et al.

NATURE (2020)

Article Pharmacology & Pharmacy

3D printing of unique water-soluble polymer-based suppository shell for controlled drug release

Tatsuaki Tagami et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

Review Endocrinology & Metabolism

Rethinking mechanisms, diagnosis and management of endometriosis

Charles Chapron et al.

NATURE REVIEWS ENDOCRINOLOGY (2019)

Article Obstetrics & Gynecology

Time to redefine endometriosis including its pro-fibrotic nature

P. Vigano et al.

HUMAN REPRODUCTION (2018)

Review Obstetrics & Gynecology

Extracellular matrix in uterine leiomyoma pathogenesis: a potential target for future therapeutics

Md Soriful Islam et al.

HUMAN REPRODUCTION UPDATE (2018)

Article Pharmacology & Pharmacy

3D printing of vaginal rings with personalized shapes for controlled release of progesterone

Junhui Fu et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Article Medicine, General & Internal

Deep Dyspareunia and Sexual Quality of Life in Women With Endometriosis

Leona K. Shum et al.

SEXUAL MEDICINE (2018)

Article Surgery

Effect of Pirfenidone on Vascular Proliferation, Inflammation and Fibrosis in an Abdominal Adhesion Rat Model

Pinar Solmaz Hasdemir et al.

JOURNAL OF INVESTIGATIVE SURGERY (2017)

Article Pharmacology & Pharmacy

Mucoadhesive in situ gel formulation for vaginal delivery of clotrimazole: formulation, preparation, and in vitro/in vivo evaluation

Seda Rencber et al.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2017)

Review Instruments & Instrumentation

Drug delivery for the treatment of endometriosis and uterine fibroids

David R. Friend

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2017)

Review Obstetrics & Gynecology

Epidemiology of uterine fibroids: a systematic review

E. A. Stewart et al.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2017)

Review Chemistry, Medicinal

A critical review about methodologies for the analysis of mucoadhesive properties of drug delivery systems

Jessica Bassi da Silva et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2017)

Article Obstetrics & Gynecology

Engineering and characterization of simplified vaginal and seminal fluid simulants

Rachna Rastogi et al.

CONTRACEPTION (2016)

Article Public, Environmental & Occupational Health

Women's experiences, preferences and perceptions regarding vaginal products: Results from a cross-sectional web-based survey in Portugal

Rita Palmeira-de-Oliveira et al.

EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE (2015)

Review Chemistry, Multidisciplinary

Nanoparticle-based drug delivery to the vagina: A review

Laura M. Ensign et al.

JOURNAL OF CONTROLLED RELEASE (2014)

Article Pharmacology & Pharmacy

Use of porcine vaginal tissue ex-vivo to model environmental effects on vaginal mucosa to toxic shock syndrome toxin-1

Catherine C. Davis et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2014)

Article Pharmacology & Pharmacy

Firmness Perception Influences Women’s Preferences for Vaginal Suppositories

Toral Zaveri et al.

Pharmaceutics (2014)

Review Medicine, General & Internal

Uterine Fibroids

Serdar E. Bulun

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Chemistry, Medicinal

Proposed design of a dissolution apparatus for vaginal formulations containing probiotics

Vinita Kale et al.

DISSOLUTION TECHNOLOGIES (2008)

Review Chemistry, Medicinal

Porcine vagina ex vivo as a model for studying permeability and pathogenesis in mucosa

Christopher A. Squier et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2008)

Review Medicine, Research & Experimental

Pathobiology of transforming growth factor β in cancer, fibrosis and immunologic disease, and therapeutic considerations

Gerald J. Prud'homme

LABORATORY INVESTIGATION (2007)

Article Pharmacology & Pharmacy

Porcine vaginal mucosa as an in vitro permeability model for human vaginal mucosa

AD van Eyk et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2005)

Review Chemistry, Multidisciplinary

The vagina as a route for systemic drug delivery

A Hussain et al.

JOURNAL OF CONTROLLED RELEASE (2005)

Review Obstetrics & Gynecology

Why consider vaginal drug administration?

NJ Alexander et al.

FERTILITY AND STERILITY (2004)