Base-Catalyzed Synthesis of Spiropyrazoloaminonitriles with Arylidene Pyrazolone and Vinylogous Malononitriles through a Cascade Michael Addition and Cyclization

Synthesis of title compounds were accomplished by a reaction of vinyl malononitriles and arylidene pyrazolones catalyzed by base. This protocol proceeds via Michael addition followed by intramolecular cyclization leading to the formation of two new C-C bonds. Further the same reaction was also conducted with alpha,alpha-dicyano olefins and vinyl malononitriles to furnish 1,6-dihydro biphenyl compounds. Simple reaction conditions, high yields and compatibility are the advantages of this protocol.

Automated summary

The title compounds were synthesized through a reaction between vinyl malononitriles and arylidene pyrazolones catalyzed by base. The reaction involves Michael addition followed by intramolecular cyclization, resulting in the formation of two new C-C bonds. Furthermore, the same reaction with alpha,alpha-dicyano olefins and vinyl malononitriles produces 1,6-dihydro biphenyl compounds. The advantages of this protocol include simple reaction conditions, high yields, and compatibility.