Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 26, Issue 31, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202300543
Keywords
amidyl radicals; C-H functionalization; hydrogen atom transfer; photocatalysis; organic synthesis
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We have reported an efficient photoredox-catalyzed reaction for site-selective C(sp(3))-H functionalization of carboxamides with silyl enol ethers as radical acceptors. The reaction proceeds through amidyl radical-directed 1,5-hydrogen atom transfer (1,5-HAT) and C(sp(3))-C(sp(3)) bond formation via radical addition of silyl enol ethers. The process exhibits mild conditions and high functional-group tolerance, enabling the preparation of a range of carboxamides with pendant carbonyl moieties.
Herein we reported an efficient photoredox-catalyzed reaction for site-selective C(sp(3))-H functionalization of carboxamides with silyl enol ethers as radical acceptors. The reaction proceeded through amidyl radical-directed 1,5-hydrogen atom transfer (1,5-HAT) and C(sp(3))-C(sp(3)) bond formation via radical addition of silyl enol ethers. The process features mild conditions and high functional-group tolerance, allowing the preparation of a series of carboxamides with pendant carbonyl moieties.
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