4.7 Article

Investigation of tetrasubstituted heterocycles reveals hydantoins as a promising scaffold for development of novel antimicrobials with membranolytic properties

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

Lulworthinone: In Vitro Mode of Action Investigation of an Antibacterial Dimeric Naphthopyrone Isolated from a Marine Fungus

Eric Juskewitz et al.

Summary: This article focuses on the antibacterial mode of action of lulworthinone, a compound that targets the bacterial membrane and disrupts cell division. The compound also affects cell morphology and localization of the cell division protein FtsZ. Its ability to form colloidal aggregates contributes to its antibacterial activity. Antibacterial agents acting on cell membranes are important due to the difficulty of bacterial resistance development.

MARINE DRUGS (2022)

Article Chemistry, Medicinal

A concise SAR-analysis of antimicrobial cationic amphipathic barbiturates for an improved activity-toxicity profile

Manuel K. Langer et al.

Summary: This study reports a promising class of antimicrobial agents, amphipathic barbiturate mimics of marine eusynstyelamides. A detailed analysis of the structure-activity relationship for cationic amphipathic barbiturates was conducted, and it was found that different cationic groups, hydrocarbon linkers, and lipophilic side chains had varying effects on their antimicrobial potency and haemolytic activity. Based on these findings, both potent narrow-spectrum and broad-spectrum barbiturates with low or no haemolytic activity were successfully prepared.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

Article Chemistry, Medicinal

Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates

Marianne H. Paulsen et al.

Summary: This study presents a series of synthetic cationic amphipathic barbiturates with potent antimicrobial activity against multi-resistant bacteria. Inspired by the pharmacophore model of small antimicrobial peptides and marine antimicrobials, these compounds show promising in vivo antibiotic efficacy and strong membrane disruptive effects. The results suggest that the design strategy based on small AMPs and marine compounds can lead to the development of highly effective peptidomimetics against multi-drug resistant bacteria.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Review Chemistry, Multidisciplinary

Towards the sustainable discovery and development of new antibiotics

Marcus Miethke et al.

Summary: There is a growing demand for novel antimicrobials to treat infections caused by multidrug-resistant bacterial pathogens, but there is currently a lack of investment in this field. New agents with innovative chemistry and modes of action are urgently needed to combat the public health threat posed by antimicrobial resistance. The consortium proposes short-term and long-term solutions to overcome urgent limitations in research and funding, aiming to bridge the gap between academic, industrial, and political stakeholders to improve the ability to discover and develop new antibiotics.

NATURE REVIEWS CHEMISTRY (2021)

Article Chemistry, Medicinal

Development of Bis-cyclic Imidazolidine-4-one Derivatives as Potent Antibacterial Agents

Minghui Wang et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Chemistry, Medicinal

Role of sulphur-heterocycles in medicinal chemistry: An update

Shelly Pathania et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

An amphipathic cyclic tetrapeptide scaffold containing halogenated 2,2-amino acids with activity against multiresistant bacteria

Marianne H. Paulsen et al.

JOURNAL OF PEPTIDE SCIENCE (2018)

Article Chemistry, Medicinal

Membrane-Active Hydantoin Derivatives as Antibiotic Agents

Ma Su et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

Article Chemistry, Multidisciplinary

Thioamide Substitution Selectively Modulates Proteolysis and Receptor Activity of Therapeutic Peptide Hormones

Xing Chen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Review Biochemistry & Molecular Biology

Proline-rich antimicrobial peptides targeting protein synthesis

Michael Graf et al.

NATURAL PRODUCT REPORTS (2017)

Review Chemistry, Multidisciplinary

Recent Advances in the Synthesis of Hydantoins: The State of the Art of a Valuable Scaffold

Laure Konnert et al.

CHEMICAL REVIEWS (2017)

Article Chemistry, Multidisciplinary

Novel bis-cyclic guanidines as potent membrane-active antibacterial agents with therapeutic potential

Peng Teng et al.

CHEMICAL COMMUNICATIONS (2017)

Article Chemistry, Medicinal

Synthesis and antimicrobial evaluation of cationic low molecular weight amphipathic 1,2,3-triazoles

Thomas A. Bakka et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)

Review Chemistry, Multidisciplinary

γ-AApeptides: Design, Structure, and Applications

Yan Shi et al.

ACCOUNTS OF CHEMICAL RESEARCH (2016)

Article Chemistry, Multidisciplinary

γ-AApeptides as a New Class of Peptidomimetics

Peng Teng et al.

CHEMISTRY-A EUROPEAN JOURNAL (2016)

Review Chemistry, Medicinal

Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry

Minghao Feng et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

The Host Antimicrobial Peptide Bac71-35 Binds to Bacterial Ribosomal Proteins and Inhibits Protein Synthesis

Mario Mardirossian et al.

CHEMISTRY & BIOLOGY (2014)

Article Chemistry, Medicinal

Small Molecular Antibacterial Peptoid Mimics: The Simpler the Better!

Chandradhish Ghosh et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

Review Chemistry, Medicinal

Thiopeptide Antibiotics: Retrospective and Recent Advances

Xavier Just-Baringo et al.

MARINE DRUGS (2014)

Article Biochemistry & Molecular Biology

Antimicrobial Resistance in the 21st Century: A Multifaceted Challenge

O. Nolte

PROTEIN AND PEPTIDE LETTERS (2014)

Article Biochemistry & Molecular Biology

Improved Protease Stability of the Antimicrobial Peptide Pin2 Substituted with D-Amino Acids

G. Carmona et al.

PROTEIN JOURNAL (2013)

Review Biotechnology & Applied Microbiology

Antimicrobial peptides: key components of the innate immune system

Mukesh Pasupuleti et al.

CRITICAL REVIEWS IN BIOTECHNOLOGY (2012)

Review Biotechnology & Applied Microbiology

Designing antimicrobial peptides: form follows function

Christopher D. Fjell et al.

NATURE REVIEWS DRUG DISCOVERY (2012)

Article Microbiology

Efficacy of Antimicrobial Peptoids against Mycobacterium tuberculosis

Rinki Kapoor et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)

Article Chemistry, Medicinal

Amine-alkyl derivatives of hydantoin: New tool to combat resistant bacteria

Jadwiga Handzlik et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)

Review Chemistry, Multidisciplinary

Contemporary strategies for peptide macrocyclization

ChHstcpher J. White et al.

NATURE CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

The Proline-rich Antibacterial Peptide Bac7 Binds to and Inhibits in vitro the Molecular Chaperone DnaK

Marco Scocchi et al.

INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS (2009)

Article Biochemistry & Molecular Biology

Dual mode of action of Bac7, a proline-rich antibacterial peptide

Elena Podda et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2006)

Article Biochemistry & Molecular Biology

Mimicking helical antibacterial peptides with nonpeptidic folding oligomers

Aude Violette et al.

CHEMISTRY & BIOLOGY (2006)

Review Chemistry, Multidisciplinary

Thiopeptide antibiotics

MC Bagley et al.

CHEMICAL REVIEWS (2005)

Review Chemistry, Organic

Recent developments in hydantoin chemistry -: A review

M Meusel et al.

ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL (2004)

Article Biochemical Research Methods

Fluoro-luminometric real-time measurement of bacterial viability and killing

J Lehtinen et al.

JOURNAL OF MICROBIOLOGICAL METHODS (2003)

Article Chemistry, Medicinal

Synthesis, structure and antiarrhythmic properties evaluation of new basic derivatives of 5,5-diphenylhydantoin

K Kiec-Kononowicz et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2003)

Letter Chemistry, Medicinal

The pharmacophore of short cationic antibacterial peptides

MB Strom et al.

JOURNAL OF MEDICINAL CHEMISTRY (2003)

Article Pharmacology & Pharmacy

Antimycobacterial activity of 5-arylidene aromatic derivatives of hydantoin

E Szymanska et al.

FARMACO (2002)