Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 252, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2023.115280
Keywords
Bis-chalcones; Flavonoids; Green synthesis; Claisen-Schmidt condensation; Inflammation
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This review article provides an overview of the chemical structure, chemical properties, and synthesis methods of bis-chalcones. It also emphasizes the anti-inflammatory activity of bis-chalcones and their mechanisms of action.
Chalcones are bioactive molecules of natural and synthetic sources, whose physicochemical properties, reac-tivity, and biological activities are well-known among the scientific community. However, there are many molecules strictly related to chalcones with significantly less recognition like bis-chalcones. Several studies indicated that bis-chalcones have advantages over chalcones in specific bioactivities like anti-inflammatory activity.This review article describes the chemical structure and chemical properties of bis-chalcones, as well as the methods reported in the literature for the synthesis of these compounds highlighting the most recent de-velopments. Finally, the anti-inflammatory activity of bis-chalcones is described, emphasizing the active struc-tures found in literature and their mechanisms of action.
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