4.5 Article

Diagnostic pathways to wild-type transthyretin amyloid cardiomyopathy: a multicentre network study

Related references

Note: Only part of the references are listed.
Article Cardiac & Cardiovascular Systems

Trends in diagnosis, referral, red flag onset, patient profiles and natural outcome of de novo cardiac amyloidosis and their multidisciplinary implications

Philippe Debonnaire et al.

Summary: This study reported trends in diagnosis, referral routes, clinical presentation, early onset diagnostic red flags, and outcomes in 139 de novo CA subjects. Despite improvements in CA diagnosis and referral, ignoring specialist-specific disease and diagnostic red flags leads to non-timely diagnosis and unfavorable outcomes.

ACTA CARDIOLOGICA (2022)

Review Biochemistry & Molecular Biology

Guidelines and new directions in the therapy and monitoring of ATTRv amyloidosis

Yukio Ando et al.

Summary: The recent approval of drugs for the treatment of ATTR amyloidosis has opened a new era in care and changed the therapeutic strategy. The drugs target critical steps of the amyloid cascade and show clinical effectiveness. However, without comparative trials, it is difficult to make specific recommendations.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2022)

Article Cardiac & Cardiovascular Systems

Unmasking the prevalence of amyloid cardiomyopathy in the real world: results from Phase 2 of the AC-TIVE study, an Italian nationwide survey

Marco Merlo et al.

Summary: This study aimed to investigate the prevalence of amyloid cardiomyopathy (AC) and the diagnostic accuracy of echocardiographic red flags of AC among consecutive adult patients undergoing transthoracic echocardiogram for reasons other than AC. The study found that the prevalence of AC (ATTR or AL) was 29% in patients with echocardiographic findings suggestive of AC, and a combination of easily available echocardiographic red flags showed good diagnostic accuracy.

EUROPEAN JOURNAL OF HEART FAILURE (2022)

Review Cardiac & Cardiovascular Systems

Redefining the epidemiology of cardiac amyloidosis. A systematic review and meta-analysis of screening studies

Alberto Aimo et al.

Summary: Searching for CA in specific settings allows for the identification of a significant number of eligible cases for treatment. ATTR-CA accounts for the majority of CA cases across different environments, but AL-CA is also relatively common. The median age at diagnosis for CA patients falls between 80 and 90 years, with many patients being women.

EUROPEAN JOURNAL OF HEART FAILURE (2022)

Article Cardiac & Cardiovascular Systems

Prevalence, characteristics, and mortality of patients with transthyretin amyloid cardiomyopathy in the Nordic countries

Rosa Lauppe et al.

Summary: This study provides nationwide estimates of the prevalence, clinical characteristics, and mortality of patients with transthyretin amyloid cardiomyopathy (ATTR-CM) across multiple countries. The findings show an increasing prevalence of ATTR-CM over time, higher mortality in female patients, and highlight the importance of accurate and early diagnosis to reduce the burden of the disease.

ESC HEART FAILURE (2022)

Article Cardiac & Cardiovascular Systems

Temporal Trends of Heart Failure Hospitalizations in Cardiology Versus Noncardiology Wards According to Ejection Fraction: 16-Year Data From the SwedeHF Registry

Marco Canepa et al.

Summary: The study found that over time, the proportion of HFpEF patients hospitalized in noncardiology wards increased gradually, while the proportions of HFrEF and HFmrEF patients treated in cardiology versus noncardiology remained substantially unchanged.

CIRCULATION-HEART FAILURE (2022)

Article Cardiac & Cardiovascular Systems

Diagnosis and treatment of cardiac amyloidosis. A position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases

Pablo Garcia-Pavia et al.

Summary: Cardiac amyloidosis is a serious and progressive infiltrative disease caused by the deposition of amyloid fibrils in the heart. With advances in imaging techniques and non-invasive diagnosis, it is now recognized as more common than traditionally believed. The Working Group on Myocardial and Pericardial Disease has proposed definitions, diagnostic algorithms, and treatment strategies to help bridge the gap between the latest research and clinical practice in managing cardiac amyloidosis.

EUROPEAN JOURNAL OF HEART FAILURE (2021)

Article Cardiac & Cardiovascular Systems

Changes in the perceived epidemiology of amyloidosis: 20 year-experience from a Tertiary Referral Centre in Tuscany

Mattia Zampieri et al.

Summary: A 20-year epidemiological study of amyloidosis patients at Careggi University Hospital in Florence, Italy found significant changes in the distribution of different types of amyloidosis over time. Wild type transthyretin amyloidosis (wtATTR) emerged as the most common etiology at the end of the observation period, contrasting with the previous absence of recognition before 2009. Serum amyloid A amyloidosis (AA) remained a residual diagnosis throughout the entire examined period.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2021)

Article Oncology

Temporal Trends of Wild-Type Transthyretin Amyloid Cardiomyopathy in the Transthyretin Amyloidosis Outcomes Survey

Jose Nativi-Nicolau et al.

Summary: In the past decade, the diagnosis of ATTRwt amyloidosis has increased globally, especially in the United States. Despite the increasing use of bone scintigraphy, patients are still diagnosed several years after symptom onset.

JACC: CARDIOONCOLOGY (2021)

Letter Cardiac & Cardiovascular Systems

Prevalence and Prognostic Significance of Frailty Among Patients With Transthyretin Amyloidosis Cardiomyopathy

Nowell M. Fine et al.

CIRCULATION-HEART FAILURE (2021)

Article Medicine, General & Internal

Yield of bone scintigraphy screening for transthyretin-related cardiac amyloidosis in different conditions: Methodological issues and clinical implications

Giacomo Tini et al.

Summary: Screening with bone scintigraphy revealed a prevalence of 11-15% of TTR-CA in patients with AS, HFpEF, and LVH/HCM. Patients with AS and HFpEF were typically older than 80 years at TTR-CA diagnosis and often had comorbidities. Several studies showed limitations in applying the recommended TTR-CA diagnostic algorithm, which should be addressed in future prospective studies.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Medicine, General & Internal

Early Diagnosis and Outcome in Patients With Wild-Type Transthyretin Cardiac Amyloidosis

Carlo Fumagalli et al.

Summary: This study investigated the long-term association between diagnostic timing and mortality in patients with ATTRwt-CA. The results showed that delayed diagnostic timing was associated with higher mortality, highlighting the importance of timely diagnosis when red flags are present.

MAYO CLINIC PROCEEDINGS (2021)

Editorial Material Cardiac & Cardiovascular Systems

Recipe for Success in Transthyretin Cardiomyopathy Monoclonal Protein Rule Out, SPECT Imaging, and Genetic Testing

Kevin M. Alexander et al.

JACC-CARDIOVASCULAR IMAGING (2021)

Review Cardiac & Cardiovascular Systems

Impact of Delayed Diagnosis and Misdiagnosis for Patients with Transthyretin Amyloid Cardiomyopathy (ATTR-CM): A Targeted Literature Review

Mark H. Rozenbaum et al.

Summary: Patients with ATTR-CM often experience diagnostic delay and misdiagnosis, leading to unnecessary or inappropriate treatments. This delay may have adverse consequences for both patients and health systems.

CARDIOLOGY AND THERAPY (2021)

Article Cardiac & Cardiovascular Systems

Prevalence of cardiac amyloidosis among adult patients referred to tertiary centres with an initial diagnosis of hypertrophic cardiomyopathy

Niccolo Maurizi et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Cost-Effectiveness of Tafamidis Therapy for Transthyretin Amyloid Cardiomyopathy

Dhruv S. Kazi et al.

CIRCULATION (2020)

Article Medicine, General & Internal

Characteristics of current heart failure patients admitted to internal medicine vs. cardiology hospital units: the VASCO study

Elisa Ricciardi et al.

INTERNAL AND EMERGENCY MEDICINE (2020)

Article Cardiac & Cardiovascular Systems

Gateway and journey of patients with cardiac amyloidosis

Daniel Dang et al.

ESC HEART FAILURE (2020)

Article Computer Science, Interdisciplinary Applications

The REDCap consortium: Building an international community of software platform partners

Paul A. Harris et al.

JOURNAL OF BIOMEDICAL INFORMATICS (2019)

Review Cardiac & Cardiovascular Systems

Expert Consensus Recommendations for the Suspicion and Diagnosis of Transthyretin Cardiac Amyloidosis

Mathew S. Maurer et al.

CIRCULATION-HEART FAILURE (2019)

Editorial Material Cardiac & Cardiovascular Systems

'A new staging system for cardiac transthyretin amyloidosis': is it already on the verge of obsolescence?

Avinainder Singh et al.

EUROPEAN HEART JOURNAL (2018)

Article Medicine, General & Internal

Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy

Mathew S. Maurer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Meeting Abstract Cardiac & Cardiovascular Systems

Short-term adverse remodelling in asymptomatic aortic stenosis: a longitudinal cardiovascular magnetic resonance imaging study

A. Singh et al.

EUROPEAN HEART JOURNAL (2018)

Article Cardiac & Cardiovascular Systems

Clinical characteristics of wild-type transthyretin cardiac amyloidosis: disprovingmyths

Esther Gonzalez-Lopez et al.

EUROPEAN HEART JOURNAL (2017)

Article Cardiac & Cardiovascular Systems

Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis

Julian D. Gillmore et al.

CIRCULATION (2016)