Altitude-induced effects on neuromuscular, metabolic and perceptual responses before, during and after a high-intensity resistance training session

Purpose We tested if an acute ascending to 2320 m above sea level (asl) affects corticospinal excitability (CSE) and intracortical inhibition (SICI) measured with transcranial magnetic stimulation (TMS) at rest, before, during and after a traditional hypertrophy-oriented resistance training (R-T) session. We also explored whether blood lactate concentration (BLa), ratings of perceived exertion (RPE), perceived muscular pain and total training volume differed when the R-T session was performed at hypoxia (H) or normoxia (N). Methods Twelve resistance-trained men performed eight sets of 10 repetitions at 70% of one repetition maximum of a bar biceps curl at N (SpO(2) = 98.0 +/- 0.9%) and H (at 2320 asl, SpO(2) = 94.0 +/- 1.9%) in random order. Before each session, a subjective well-being questionnaire, the resting motor threshold (rMT) and a single pulse recruitment curve were measured. Before, during and after the R-T session, BLa, RPE, muscle pain, CSE and SICI were measured. Results Before the R-T session only the rMT differed between H (- 5.3%) and N (ES = 0.38). RPE, muscle pain and BLa increased through the R-T session and were greater at H than N (12%, 54% and 15%, respectively) despite a similar training volume (1618 +/- 468 kg vs. 1638 +/- 509 kg). CSE was reduced during the R-T session (similar to 27%) but recovered ten minutes after, regardless of the environmental condition. SICI did not change after any R-T session. Conclusions The data suggest that acute exposure to moderate hypoxia slightly increased the excitability of the most excitable structures of the corticospinal tract but did not influence intracortical or corticospinal responses to a single R-T session.

Automated summary

The study tested the effects of acute exposure to high altitude on corticospinal excitability and intracortical inhibition, as well as the effects of training in hypoxia and normoxia. The results showed that training in hypoxia resulted in higher ratings of perceived exertion, muscle pain, and lactate concentration, but did not significantly influence corticospinal excitability and intracortical inhibition.