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Why Y? The Y chromosome may serve a cardiovascular purpose after all

EUROPEAN HEART JOURNAL (2023)

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Article Multidisciplinary Sciences

Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality

Soichi Sano et al.

Summary: This study finds that hematopoietic mosaic loss of Y chromosome (mLOY) is associated with increased risk of mortality and age-related diseases in men. The animal experiment results show that male mice reconstituted with bone marrow cells lacking the Y chromosome display increased mortality and age-related profibrotic pathologies including reduced cardiac function. Further research reveals that cardiac macrophages lacking the Y chromosome exhibit polarization toward a more fibrotic phenotype, and treatment with a specific antibody can alleviate cardiac dysfunction. A prospective study also reveals that mLOY in blood is associated with an increased risk for cardiovascular disease and heart failure-associated mortality.

SCIENCE (2022)

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Article Cardiac & Cardiovascular Systems