Magnetic resonance assessment of left atrial scar formation following a novel very high-power short-duration workflow for atrial fibrillation ablation

Aims Atrial fibrillation (AF) ablation protocols using energy delivery with very high power and short duration (vHPSD) have been introduced to improve lesion formation. This study reports procedural data of vHPSD ablation in AF patients and analyses characteristics of ablation-induced left atrial (LA) scar formation from cardiac magnetic resonance imaging (MRI). Methods and results Sixty consecutive patients undergoing index pulmonary vein isolation following our institutional Q4U-AF workflow were prospectively enrolled. Ablation was conducted using a contact force sensing catheter allowing for vHPSD ablation using a temperature-controlled ablation mode. Thirty patients underwent cardiac late gadolinium enhancement MRI of the LA 3 months after ablation to assess LA scar. Mean procedural duration was 66.5 +/- 14.8 min. Mean ablation time was 4.7 +/- 0.9 min with a mean number of 69.9 +/- 14.2 applications. First-pass isolation was achieved in 51 patients (85%) for the right pulmonary veins (RPVs), in 37 patients (61.7%) for the left pulmonary veins (LPVs), and in 34 patients (56.7%) for both pulmonary veins (PVs). Magnetic resonance imaging at 3 months post-ablation demonstrated a mean scar width of 14.4 +/- 2.6 mm around RPVs and 11.9 +/- 1.9 mm at LPVs (P > 0.05). Complete PV encirclement was observed in 76.7% for RPVs, in 76.7% for LPVs, and in 66.7% for both PV pairs. During a mean follow-up of 4.7 +/- 1.4 months, arrhythmia recurrence was observed in 3.3% of the patients. Conclusion Pulmonary vein isolation following a novel vHPSD workflow resulted in short procedure duration and high acute and mid-term efficacy. Magnetic resonance imaging demonstrated durable and transmural PV lesions with homogeneous and contiguous scar formation.

Automated summary

This study evaluated the procedural data and the scar formation in atrial fibrillation (AF) patients who underwent ablation using high-power and short-duration (vHPSD) energy delivery. The results showed that vHPSD ablation resulted in shorter procedure duration, high efficacy, and durable pulmonary vein (PV) lesions. Cardiac magnetic resonance imaging (MRI) demonstrated homogeneous and contiguous scar formation. The advantages of vHPSD ablation are the quick and effective procedure, while the limitation is the small sample size.