4.5 Article

Targeted epigenetic silencing of UCHL1 expression suppresses collagen-1 production in human lung epithelial cells

Related references

Note: Only part of the references are listed.
Article Cell Biology

Ubiquitin carboxyl-terminal hydrolase isozyme L1/UCHL1 suppresses epithelial-mesenchymal transition and is under-expressed in cadmium-transformed human bronchial epithelial cells

Dan-Dan Wu et al.

Summary: Chronic exposure to cadmium can lead to a variety of diseases including cancer. By studying cadmium-transformed human lung epithelial cells, researchers identified differentially expressed proteins in five subcellular fractions and found that UCHL1 plays a crucial role in suppressing EMT. This suggests that UCHL1 could be a potential therapeutic target for chronic cadmium-induced carcinogenesis.

CELL BIOLOGY AND TOXICOLOGY (2021)

Article Biochemistry & Molecular Biology

Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing

James K. Nunez et al.

Summary: CRISPRoff is a programmable epigenetic memory writer that can heritably alter gene expression by initiating specific DNA methylation and gene repression. The tool utilizes a single dead Cas9 fusion protein to establish these modifications, which are maintained through cell division and differentiation processes. By pairing CRISPRoff with genome-wide screens and analysis of chromatin marks, rules for heritable gene silencing can be established, with the tool capable of targeting a wide range of genes beyond canonical CpG islands.
Article Pharmacology & Pharmacy

UCHL1 inhibition attenuates cardiac fibrosis via modulation of nuclear factor-KB signaling in fibroblasts

Zheng Gong et al.

Summary: The study found that UCHL1 promotes angiotensin II-induced cardiac fibrotic responses by activating the NF-KB signaling pathway, and inhibition of the NF-KB pathway can interfere with the fibrotic responses caused by UCHL1 overexpression. This suggests that UCHL1 positively regulates cardiac fibrosis by modulating the NF-KB signaling pathway.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Construction and validation of the CRISPR/dCas9-EZH2 system for targeted H3K27Me3 modification

Xutao Chen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Next-generation characterization of the Cancer Cell Line Encyclopedia

Mahmoud Ghandi et al.

NATURE (2019)

Article Genetics & Heredity

Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner

Henriette O'Geen et al.

EPIGENETICS & CHROMATIN (2019)

Article Medicine, Research & Experimental

Epigenetic Targeting of Granulin in Hepatoma Cells by Synthetic CRISPR dCas9 Epi-suppressors

Hong Wang et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2018)

Article Toxicology

Molecular Impact of Electronic Cigarette Aerosol Exposure in Human Bronchial Epithelium

Elizabeth Moses et al.

TOXICOLOGICAL SCIENCES (2017)

Article Biochemistry & Molecular Biology

dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression

Henriette O'Geen et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Multidisciplinary Sciences

Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors

Emily A. Saunderson et al.

NATURE COMMUNICATIONS (2017)

Article Physiology

Targeted epigenetic editing of SPDEF reduces mucus production in lung epithelial cells

Juan Song et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2017)

Article Biochemistry & Molecular Biology

Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing

Angelo Amabile et al.

Article Multidisciplinary Sciences

Dynamics of epigenetic regulation at the single-cell level

Lacramioara Bintu et al.

SCIENCE (2016)

Article Multidisciplinary Sciences

Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner

David Cano-Rodriguez et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

Silvana Konermann et al.

NATURE (2015)

Article Pharmacology & Pharmacy

Roflumilast N-oxide inhibits bronchial epithelial to mesenchymal transition induced by cigarette smoke in smokers with COPD

Javier Milara et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2014)

Review Respiratory System

Tissue remodelling in chronic bronchial diseases: from the epithelial to mesenchymal phenotype

Mallory Pain et al.

EUROPEAN RESPIRATORY REVIEW (2014)

Article Biochemistry & Molecular Biology

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

Jianjiong Gao et al.

SCIENCE SIGNALING (2013)

Article Respiratory System

Cigarette smoke impairs airway epithelial barrier function and cell-cell contact recovery

I. H. Heijink et al.

EUROPEAN RESPIRATORY JOURNAL (2012)

Article Genetics & Heredity

Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema

Taehong Min et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2011)

Article Biochemistry & Molecular Biology

NF-κB signaling inhibits ubiquitin carboxyl-terminal hydrolase L1 gene expression

Ruitao Wang et al.

JOURNAL OF NEUROCHEMISTRY (2011)

Review Multidisciplinary Sciences

The Polycomb complex PRC2 and its mark in life

Raphael Margueron et al.

NATURE (2011)

Article Pathology

Significance of PGP9.5 Expression in Cancer-Associated Fibroblasts for Prognosis of Colorectal Carcinoma

Yuri Akishima-Fukasawa et al.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2010)

Review Pathology

The Pathology of Chronic Obstructive Pulmonary Disease

James C. Hogg et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2009)

Article Biochemistry & Molecular Biology

Mutational analysis of the CG recognizing DNA methyltransferase SssI: Insight into enzyme-DNA interactions

Maria V. Darii et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2009)

Article Multidisciplinary Sciences

Expression and Functional Studies of Ubiquitin C-Terminal Hydrolase L1 Regulated Genes

Anjali Bheda et al.

PLOS ONE (2009)

Article Biochemistry & Molecular Biology

Identification of potential lung cancer biomarkers using an in vitro carcinogenesis model

Jung Eun Kim et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2008)

Article Oncology

The role of PGP9.5 as a tumor suppressor gene in human cancer

Yutaka Tokumaru et al.

INTERNATIONAL JOURNAL OF CANCER (2008)

Article Multidisciplinary Sciences

Effects of cigarette smoke on the human airway epithelial cell transcriptome

A Spira et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line

YC Liu et al.

CHEMISTRY & BIOLOGY (2003)