Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 99, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.etap.2023.104121
Keywords
Metal; Antioxidant defences; Acetylcholinesterase; DNA damage; Swimming pattern
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Cd exposure in Neotropical fish led to metal accumulation in various organs, DNA damage, lipid peroxidation, changes in catalase activity and swimming behavior.
In order to evaluate the effects of Cd, juveniles of the Neotropical fish Prochilodus lineatus were exposed to 1 and 10 mu g L-1 Cd, for 24 and 96 h. Fish exposed to Cd showed metal accumulation in the gills, kidney, and liver, an increase in DNA damage in erythrocytes, and an increase in lipid peroxidation (LPO) in the kidney. Cd exposure also caused a reduction in catalase activity, metallothionein induction, and LPO in the liver. Cd stimulated the swimming activity of exposed fish, resulting in longer swimming times and distances travelled, especially for the shortest exposure time. Changes in acetylcholinesterase activity (AChE) in the muscle and brain are probably related to these behavioural responses. These results show that Cd affects the functioning of several organs in P. lineatus, which is indicated by the genotoxic damage and changes in the AChE and swimming pattern of the exposed fish.
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