Screening of phthalate and non-phthalate plasticizers and bisphenols in Sicilian women's blood

The plastic accumulation and its degradation into microplastics is an environmental issue not only for their ubiquity, but also for the release of intrinsic chemicals, such as phthalates (PAEs), non-phthalate plasticizers (NPPs), and bisphenols (BPs), which may reach body organs and tissues, and act as endocrine disruptors. Monitoring plastic additives in biological matrices, such as blood, may help in deriving relationships between human exposure and health outcomes. In this work, the profile of PAEs, NPPs and BPs was determined in Sicilian women's blood with different ages (20-60 years) and interpreted by chemometrics. PAEs (DiBP and DEPH), NPPs (DEHT and DEHA), BPA and BPS were at higher frequencies and greater levels in women's blood and varied in relation to age. According to statistical analysis, younger females' blood had higher contents of plasticizers than older women, probably due to a more frequent use of higher quantities of plastic products in daily life.

Automated summary

Plastic accumulation and degradation into microplastics is an environmental issue due to their widespread presence and release of intrinsic chemicals that can act as endocrine disruptors. Monitoring plastic additives in biological matrices, such as blood, can help understand the relationship between human exposure and health outcomes. This study analyzed the levels and frequencies of specific plasticizers in Sicilian women's blood of different ages, finding higher concentrations in younger females, possibly due to increased use of plastic products in daily life.