PLS3 promotes papillary thyroid carcinoma progression by activating the Notch signaling pathway

Article Oncology

ASAP2 interrupts c-MET-CIN85 interaction to sustain HGF/c-MET-induced malignant potentials in hepatocellular carcinoma

Xiao-Lu Ma et al.

Summary: ASAP2 is highly expressed in HCC and predicts poor prognosis. Knocking down ASAP2 inhibits proliferation, migration, and invasion, while promoting apoptosis in HCC cells. ASAP2 promotes HCC cell growth and facilitates lung metastasis.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2023)

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Editorial Material Biochemistry & Molecular Biology

Recent Advances in Thyroid Cancer Research

Daniela Grimm

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Endocrinology & Metabolism

The epidemiological landscape of thyroid cancer worldwide: GLOBOCAN estimates for incidence and mortality rates in 2020

Margherita Pizzato et al.

Summary: The incidence rates of thyroid cancer in 2020 were higher in high human development index countries compared to low and medium human development index countries. However, mortality rates were relatively similar across different settings. This suggests an overdiagnosis effect in many countries and confirms the relevance of thyroid cancer overdiagnosis as a global public health problem.

LANCET DIABETES & ENDOCRINOLOGY (2022)

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Review Biochemistry & Molecular Biology

Notch signaling pathway: architecture, disease, and therapeutics

Binghan Zhou et al.

Summary: The NOTCH gene and signaling pathway have been studied for 110 years and play important roles in the development, homeostasis, and related diseases of tissues and organs. However, recent studies have found that the outcomes of NOTCH signaling are context-dependent. In terms of cancer, NOTCH signaling can both promote and inhibit tumor development. NOTCH-targeted therapies in clinical trials have not met expectations, and NOTCH mutations may serve as predictive biomarkers for immune checkpoint blockade therapy in many cancers.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Article Oncology

Plastin-3 is a diagnostic and prognostic marker for pancreatic adenocarcinoma and distinguishes from diffuse large B-cell lymphoma

Fei Xiong et al.

Summary: Altered expression of Plastin-3 (PLS3) was found to be associated with human carcinogenesis, particularly pancreatic ductal adenocarcinoma (PDA). PLS3 was identified as a potential biomarker for predicting PDA prognosis and distinguishing PDA from diffuse large B-cell lymphoma (DLBCL). Analysis of differentially expressed genes (DEGs) revealed that PLS3 expression was correlated with poor overall survival of PDA patients, with high accuracy in distinguishing PDA from DLBCL. Additionally, PLS3 expression levels were found to be associated with certain genes, such as KRT7, SPP1, and SPARC.

CANCER CELL INTERNATIONAL (2021)

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Review Biochemistry & Molecular Biology

Plastin 3 in health and disease: a matter of balance

Lisa Wolff et al.

Summary: PLS3, previously considered as a less important actin-binding protein, has now been found to play crucial roles in various cellular processes, signaling pathways, and diseases. Its expression variability due to skewed X-inactivation can lead to cancer, while its upregulation may be protective in spinal muscular atrophy. Precise balance of PLS3 levels is critical as both deficiency and excess can have detrimental effects on health.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

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Article Chemistry, Analytical