4.7 Article

Metagenomic evidence for antibiotics-driven co-evolution of microbial community, resistome and mobilome in hospital sewage

Related references

Note: Only part of the references are listed.
Article Environmental Sciences

Antibiotic resistance genes of emerging concern in municipal and hospital wastewater from a major Swedish city

Marion Hutinel et al.

Summary: This study investigates the presence and prevalence of antibiotic resistance genes (ARGs) in wastewater samples. The targeted analysis reveals high carriage of ARGs in wastewater, indicating potential release into the environment. The study also explores the relationship between bacterial composition and ARGs, suggesting possible bacterial hosts for these genes. The findings highlight the importance of understanding ARG contamination in wastewater and its potential impact on bacterial infections and treatment.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

Article Biochemical Research Methods

geneRFinder: gene finding in distinct metagenomic data complexities

Raissa Silva et al.

Summary: The study introduces a machine-learning based gene predictor, geneRFinder, which performs well in handling high-complexity metagenomic data. Compared to existing tools, geneRFinder shows significant differences in average prediction rates and higher specificity rates.

BMC BIOINFORMATICS (2021)

Article Environmental Sciences

Antimicrobial resistance bacteria and genes detected in hospital sewage provide valuable information in predicting clinical antimicrobial resistance

Leshan Cai et al.

Summary: This study revealed the association between extensive antibiotic usage and development of antibiotic-resistant bacteria and genes, as well as their impact on environmental and human health. It was found that antibiotic use influenced the resistance profiles of bacteria, with different bacteria showing varying levels of resistance.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Environmental Sciences

Reponses of microbial community and antibiotic resistance genes to the selection pressures of ampicillin, cephalexin and chloramphenicol in activated sludge reactors

Renxin Zhao et al.

Summary: The study found that high concentrations of antibiotics significantly reduced microbial diversity, altered microbial community structures, resulting in a substantial increase of ARGs and changes in ARG profiles, as well as evident enrichment of non-corresponding ARG types. Additionally, network analysis revealed obvious co-occurrence patterns among different ARG types, indicating the potential for resistance co-selection.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Environmental Sciences

Co-selection of antibiotic resistance genes, and mobile genetic elements in the presence of heavy metals in poultry farm environments

Sohaib H. Mazhar et al.

Summary: Environmental selection of antibiotic resistance genes (ARGs) in livestock is primarily influenced by metal residues, with metals having a greater impact on ARG profile compared to antibiotics. Bacterial composition and horizontal gene transfer are key factors shaping the composition of ARGs.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Environmental Sciences

Investigating the effects of municipal and hospital wastewaters on horizontal gene transfer

Marion Hutinel et al.

Summary: In this study, it was found that chemicals present in municipal wastewater did not induce horizontal gene transfer (HGT), while exposure to hospital wastewater led to an increase in the number of recipients acquiring sulfonamide resistance. Although concentrations were generally higher in hospital wastewater, none of the measured substances could individually explain its effects; the majority of captured mobile genetic elements were Inch plasmids.

ENVIRONMENTAL POLLUTION (2021)

Article Multidisciplinary Sciences

Forecasting the dissemination of antibiotic resistance genes across bacterial genomes

Mostafa M. H. Ellabaan et al.

Summary: Antibiotic resistance spreads among bacteria through horizontal transfer of antibiotic resistance genes. Researchers identified potential mobilization elements and other features associated with ARG transfer among bacterial clades, predicting the potential future dissemination of known ARGs.

NATURE COMMUNICATIONS (2021)

Article Engineering, Environmental

Shotgun metagenomics assessment of the resistome, mobilome, pathogen dynamics and their ecological control modes in full-scale urban wastewater treatment plants

Popi Karaolia et al.

Summary: Both full-scale UWTPs significantly reduced BOD5 (99.4-99.9%), COD (97.6-99.4%) and TSS (98.9-99.9%). MBR was more effective in reducing the abundance and diversity of pathogen-containing taxa, with 4 and 30 taxa enriched in MBR and CAS effluents, respectively.

JOURNAL OF HAZARDOUS MATERIALS (2021)

Review Environmental Sciences

Monitoring antibiotic resistance genes in wastewater treatment: Current strategies and future challenges

Anh Q. Nguyen et al.

Summary: Antimicrobial resistance (AMR) is a growing threat to human and animal health. Wastewater treatment plants can either act as a pathway for AMR spread or as a barrier to reduce the environmental release of anthropogenic AMR. State of the art ARB identification technologies have enriched ARG/ARB databases, unveiled keystone species in AMR networks, and improved the resolution of AMR dissemination models.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Environmental Sciences

Antibiotic resistance genes and mobile genetic elements in a rural river in Southeast China: Occurrence, seasonal variation and association with the antibiotics

Xinshu Jiang et al.

Summary: This study found multiple antibiotic resistance genes in rural rivers, with sul1, sul2, and int1 being the dominant target genes in water samples. The distribution of ARGs is affected by different seasons and spatial locations, suggesting that pollution of antibiotic resistance genes by rural activities must be a concern.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Engineering, Environmental

Anthropogenic disturbances on antibiotic resistome along the Yarlung Tsangpo River on the Tibetan Plateau: Ecological dissemination mechanisms of antibiotic resistance genes to bacterial pathogens

Sheng Liu et al.

Summary: Human activities accelerate the prevalence of the antibiotic resistome and pose threats to ecological safety and public health globally. The biogeography of antibiotic resistance genes (ARGs) and pathogenic antibiotic resistant bacteria (PARB) under anthropogenic disturbances along the Yarlung Tsangpo River was studied using a metagenomic approach. Human activities significantly promote the dissemination of ARGs and PARB along the river, with land use pattern identified as a key factor influencing ARG composition.

WATER RESEARCH (2021)

Article Biochemistry & Molecular Biology

Cartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environment

Kern Rei Chng et al.

NATURE MEDICINE (2020)

Review Environmental Sciences

Review of antibiotic resistance in China and its environment

Min Qiao et al.

ENVIRONMENT INTERNATIONAL (2018)

Article Environmental Sciences

Relationship between modification of activated sludge wastewater treatment and changes in antibiotic resistance of bacteria

Ewa Korzeniewska et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2018)

Review Microbiology

Mobile Genetic Elements Associated with Antimicrobial Resistance

Sally R. Partridge et al.

CLINICAL MICROBIOLOGY REVIEWS (2018)

Article Environmental Sciences

An underappreciated hotspot of antibiotic resistance: The groundwater near the municipal solid waste landfill

Qing-Lin Chen et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2017)

Article Biotechnology & Applied Microbiology

The Bacterial Mobile Resistome Transfer Network Connecting the Animal and Human Microbiomes

Yongfei Hu et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2016)

Article Environmental Sciences

Long-term field application of sewage sludge increases the abundance of antibiotic resistance genes in soil

Qinglin Chen et al.

ENVIRONMENT INTERNATIONAL (2016)

Article Environmental Sciences

Elucidating selection processes for antibiotic resisitance in sewage treatment plants using metagenomics

Johan Bengtsson-Palme et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2016)

Review Microbiology

Dissemination of Antimicrobial Resistance in Microbial Ecosystems through Horizontal Gene Transfer

Christian J. H. von Wintersdorff et al.

FRONTIERS IN MICROBIOLOGY (2016)

Article Multidisciplinary Sciences

Gut microbiome development along the colorectal adenoma-carcinoma sequence

Qiang Feng et al.

NATURE COMMUNICATIONS (2015)

Article Infectious Diseases

blaTEM and vanA as indicator genes of antibiotic resistance contamination in a hospital-urban wastewater treatment plant system

Carlos Narciso-da-Rocha et al.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2014)

Article Microbiology

The Comprehensive Antibiotic Resistance Database

Andrew G. McArthur et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)

Review Microbiology

Plasmids and the spread of resistance

Alessandra Carattoli

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2013)

Article Biotechnology & Applied Microbiology

Horizontal transfer of antibiotic resistance genes in a membrane bioreactor

Dong Yang et al.

JOURNAL OF BIOTECHNOLOGY (2013)

Review Microbiology

Broad-host-range IncP-1 plasmids and their resistance potential

Magdalena Popowska et al.

FRONTIERS IN MICROBIOLOGY (2013)

Article Infectious Diseases

Identification of acquired antimicrobial resistance genes

Ea Zankari et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2012)

Article Biochemical Research Methods

Fast gapped-read alignment with Bowtie 2

Ben Langmead et al.

NATURE METHODS (2012)

Article Multidisciplinary Sciences

Nanoalumina promotes the horizontal transfer of multiresistance genes mediated by plasmids across genera

Zhigang Qiu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

The Shared Antibiotic Resistome of Soil Bacteria and Human Pathogens

Kevin J. Forsberg et al.

SCIENCE (2012)

Review Microbiology

Long-term impacts of antibiotic exposure on the human intestinal microbiota

Cecilia Jernberg et al.

MICROBIOLOGY-SGM (2010)

Review Microbiology

Studying plasmid horizontal transfer in situ: A critical review

SJ Sorensen et al.

NATURE REVIEWS MICROBIOLOGY (2005)

Review Microbiology

Mechanisms of, and barriers to, horizontal gene transfer between bacteria

CM Thomas et al.

NATURE REVIEWS MICROBIOLOGY (2005)

Review Microbiology

Mobile genetic elements: The agents of open source evolution

LS Frost et al.

NATURE REVIEWS MICROBIOLOGY (2005)