Journal
CERAMICS INTERNATIONAL
Volume 41, Issue 1, Pages 1671-1676Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceramint.2014.09.108
Keywords
Silver nanoparticles; Hydroxyapatite; Porous scaffold; Antibacterial activity
Categories
Funding
- EU [269113]
- National Natural Science Foundation of China [21074041, 81371939]
- State Key Lab of Materials Processing and Die & Mold Technology [2014-5]
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Silver nanoparticle (Ag-np) is a new kind of antibacterial agent which is widely used in medical supplies. In this study, a simple approach is described to obtain Ag-doped HA scaffolds. Hydroxyapatite (HA) bone scaffolds with controllable pore size were fabricated by a micro-syringe extrusion system. Sintered HA scaffolds were then immersed in silver reaction hydrosol in order to get Ag-doped HA scaffolds. SEM and EDS shows a uniform distribution of silver nanoparticles on the surface of HA scaffolds. Such Ag-np doped HA scaffolds, displaying a good antibacterial activity against Escherichia coli (E. coli), are likely to prevent bone implant associated bacterial infections. (C) 2014 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
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