4.8 Editorial Material

A novel empeROR of pancreatic malignancy

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

YAP/BRD4-controlled ROR1 promotes tumor-initiating cells and hyperproliferation in pancreatic cancer

Masaya Yamazaki et al.

Summary: Tumor-initiating cells with high expression of receptor tyrosine kinase-like orphan receptor 1 (ROR1) have partial epithelial-mesenchymal transition (EMT)-like signature and act as the origin of heterogeneous tumor cells in PDAC. ROR1 depletion suppresses tumor growth, recurrence after chemotherapy, and metastasis by inducing the expression of Aurora kinase B (AURKB) through activating E2F via c-Myc. ROR1 is transcriptionally dependent on YAP/BRD4 binding at the enhancer region and targeting this pathway reduces ROR1 expression and prevents PDAC growth.

EMBO JOURNAL (2023)

Review Oncology

Translational advances in pancreatic ductal adenocarcinoma therapy

Abdel Nasser Hosein et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer that is often diagnosed at advanced stages, leading to limited treatment options. Recent advancements in targeted therapy and immunotherapy for different subtypes of PDAC are reviewed in this article, with a focus on the current preclinical and clinical evidence supporting these approaches and the potential of combination treatments.

NATURE CANCER (2022)

Review Oncology

Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data

Ashton A. Connor et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest epithelial malignancies, with increasing research over several decades leading to a better understanding of its carcinogenesis and significant progress in genomics and transcriptomics. The inclusion of PDAC data in international pan-cancer analyses has provided further insights, and the study of PDAC evolution and heterogeneity has led to the proposal of an evolutionary model based on genomics studies of human PDAC.

NATURE REVIEWS CANCER (2022)

Article Oncology

Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade

Shivani Srivastava et al.

Summary: CAR-T therapy shows limited efficacy in lung adenocarcinoma, but combining oxaliplatin, cyclophosphamide, and anti-PD-L1 can improve CAR-T cell infiltration into tumors and enhance efficacy.

CANCER CELL (2021)

Article Multidisciplinary Sciences

Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis

Ievgenia Pastushenko et al.

Summary: This study reveals that mutation of the FAT1 gene promotes tumor initiation, progression, invasiveness, stemness, and metastasis. Loss of function of FAT1 activates a CAMK2-CD44-SRC axis while inactivates EZH2, playing important roles in the expression of YAP1 and ZEB1.

NATURE (2021)

Article Oncology

TNF-α-producing macrophages determine subtype identity and prognosis via AP1 enhancer reprogramming in pancreatic cancer

Mengyu Tu et al.

Summary: Large-scale genomic profiling of pancreatic cancer has identified two distinct subtypes - 'classical' and 'basal-like' - within the stromal immune microenvironment, influencing differential prognosis. Basal-like neoplastic state is sustained through BRD4-mediated cJUN/AP1 expression, inducing CCL2 to recruit TNF-alpha-secreting macrophages, which in turn forces classical neoplastic cells into an aggressive state via lineage reprogramming. Integration of various data sources revealed JUNB/AP1 (classical) and cJUN/AP1 (basal-like) driven regulation of PDAC subtypes.

NATURE CANCER (2021)

Article Genetics & Heredity

Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution

Michelle Chan-Seng-Yue et al.

NATURE GENETICS (2020)

Review Gastroenterology & Hepatology

Molecular subtypes of pancreatic cancer

Eric A. Collisson et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Article Multidisciplinary Sciences

Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes

Gwen Lomberk et al.

NATURE COMMUNICATIONS (2018)