4.8 Article

Phospholipid scramblase Xkr8 is required for developmental axon pruning via phosphatidylserine exposure

Related references

Note: Only part of the references are listed.
Article Immunology

Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine

Chihiro Kurematsu et al.

Summary: This study demonstrates the involvement of phosphatidylserine (PS) in the synaptic pruning and functional maturation of adult-born neurons in the olfactory bulb and hippocampus. Using an inducible transgenic mouse model, the researchers found that impaired microglial spine pruning and altered electrophysiological properties of adult-born neurons occurred when PS exposure was masked by a dominant-negative form of milk fat globule-EGF-factor 8 (MFG-E8). These findings highlight the significance of PS in microglial pruning and the maturation of adult-born neurons.

JOURNAL OF EXPERIMENTAL MEDICINE (2022)

Article Biochemistry & Molecular Biology

The tertiary structure of the human Xkr8-Basigin complex that scrambles phospholipids at plasma membranes

Takaharu Sakuragi et al.

Summary: Xkr8-Basigin is a plasma membrane phospholipid scramblase activated by kinases or caspases. The structure revealed key charged residues essential for its scrambling activity, with phosphatidylcholine binding in a hydrophobic cleft on the surface. The tryptophan residue between the head group of phosphatidylcholine and the extracellular end plays a crucial role in regulating the scramblase activity.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)

Review Psychiatry

Neuroplastin in human cognition: review of literature and future perspectives

Katarina Ilic et al.

Summary: Neuroplastin, a synaptic glycoprotein, plays a crucial role in synaptic plasticity, cognition, and memory formation. It is involved in regulating calcium homeostasis and is associated with genetic traits like cortical thickness, intelligence, schizophrenia, and autism in humans. Future studies may shed more light on its role as a key molecule in human cognition.

TRANSLATIONAL PSYCHIATRY (2021)

Article Biochemistry & Molecular Biology

Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia

Nicole Scott-Hewitt et al.

EMBO JOURNAL (2020)

Review Neurosciences

Challenges and future directions for representations of functional brain organization

Janine Bijsterbosch et al.

NATURE NEUROSCIENCE (2020)

Article Neurosciences

Deletion of Autism Risk Gene Shank3 Disrupts Prefrontal Connectivity

Marco Pagani et al.

JOURNAL OF NEUROSCIENCE (2019)

Review Cell Biology

Developmental Cell Death in the Cerebral Cortex

Fong Kuan Wong et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 35 (2019)

Article Biochemistry & Molecular Biology

Infraslow State Fluctuations Govern Spontaneous fMRI Network Dynamics

Daniel Gutierrez-Barragan et al.

CURRENT BIOLOGY (2019)

Article Multidisciplinary Sciences

Transient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity

N. S. De Leon Reyes et al.

NATURE COMMUNICATIONS (2019)

Review Immunology

How macrophages deal with death

Greg Lemke

NATURE REVIEWS IMMUNOLOGY (2019)

Article Developmental Biology

Sexual dimorphism of microglia and synapses during mouse postnatal development

Laetitia Weinhard et al.

DEVELOPMENTAL NEUROBIOLOGY (2018)

Article Multidisciplinary Sciences

Local apoptotic-like mechanisms underlie complement mediated synaptic pruning

Balazs A. Gyorffy et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

Laetitia Weinhard et al.

NATURE COMMUNICATIONS (2018)

Review Neurosciences

Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders

Urte Neniskyte et al.

NATURE REVIEWS NEUROSCIENCE (2017)

Article Multidisciplinary Sciences

Organizing principles for the cerebral cortex network of commissural and association connections

Larry W. Swanson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Biochemistry & Molecular Biology

Exposure of phosphatidylserine on the cell surface

S. Nagata et al.

CELL DEATH AND DIFFERENTIATION (2016)

Article Multidisciplinary Sciences

Schizophrenia risk from complex variation of complement component 4

Aswin Sekar et al.

NATURE (2016)

Article Multidisciplinary Sciences

Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure

Jun Suzuki et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biochemistry & Molecular Biology

Exposure of Phosphatidylserine by Xk-related Protein Family Members during Apoptosis

Jun Suzuki et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Review Neurosciences

Neuromuscular synaptogenesis: coordinating partners with multiple functions

Houssam Darabid et al.

NATURE REVIEWS NEUROSCIENCE (2014)

Article Neurosciences

Distributed BOLD and CBV-weighted resting-state networks in the mouse brain

Francesco Sforazzini et al.

NEUROIMAGE (2014)

Article Mathematical & Computational Biology

Synaptic bouton properties are tuned to best fit the prevailing firing pattern

Markus M. Knodel et al.

FRONTIERS IN COMPUTATIONAL NEUROSCIENCE (2014)

Article Biochemistry & Molecular Biology

Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members

Jun Suzuki et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Neurosciences

Glial Cells Decipher Synaptic Competition at the Mammalian Neuromuscular Junction

Houssam Darabid et al.

JOURNAL OF NEUROSCIENCE (2013)

Article Multidisciplinary Sciences

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

Won-Suk Chung et al.

NATURE (2013)

Article Multidisciplinary Sciences

ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC

Jacqueline L. Blankman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Clinical Neurology

Presynaptically Silent Synapses: Dormancy and Awakening of Presynaptic Vesicle Release

Devon C. Crawford et al.

NEUROSCIENTIST (2012)

Article Multidisciplinary Sciences

Diurnal, localized exposure of phosphatidylserine by rod outer segment tips in wild-type but not Itgb5-/- or Mfge8-/- mouse retina

Linda Ruggiero et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Biochemistry & Molecular Biology

Emerging roles for lysophosphatidylserine in resolution of inflammation

S. Courtney Frasch et al.

PROGRESS IN LIPID RESEARCH (2012)

Article Multidisciplinary Sciences

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

Rosa C. Paolicelli et al.

SCIENCE (2011)

Article Neurosciences

Network-based statistic: Identifying differences in brain networks

Andrew Zalesky et al.

NEUROIMAGE (2010)

Article Biochemistry & Molecular Biology

The classical complement cascade mediates CNS synapse elimination

Beth Stevens et al.

Article Biochemistry & Molecular Biology

Identification of novel peptide hormones in the human proteome by hidden Markov model screening

Olivier Mirabeau et al.

GENOME RESEARCH (2007)

Article Neurosciences

Local caspase activity directs engulfment of dendrites during pruning

Darren W. Williams et al.

NATURE NEUROSCIENCE (2006)

Review Neurosciences

Exuberance in the development of cortical networks

GM Innocenti et al.

NATURE REVIEWS NEUROSCIENCE (2005)

Article Biochemistry & Molecular Biology

Diverse modes of axon elaboration in the developing neocortex

C Portera-Cailliau et al.

PLOS BIOLOGY (2005)

Article Multidisciplinary Sciences

Silent synapses in the developing hippocampus: Lack of functional AMPA receptors or low probability of glutamate release?

S Gasparini et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)