Radiographic duodenal invasion is associated with poor prognosis and early recurrence in patients with pancreatic ductal adenocarcinoma

Article Gastroenterology & Hepatology

Preoperative carbohydrate antigen 19-9 and standard uptake value of positron emission tomography-computed tomography as prognostic markers in patients with pancreatic ductal adenocarcinoma

Dokyoon Moon et al.

Summary: Preoperative CA19-9 level and SUVmax play important roles in the prognosis of resectable pancreatic ductal adenocarcinoma, with patients having high CA19-9 level and SUVmax not being suitable for upfront surgery.

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES (2022)

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Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

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Article Oncology

Landmark Series: Neoadjuvant Treatment in Borderline Resectable Pancreatic Cancer

Jin He et al.

Summary: The definition of BRPC should consider biological and conditional dimensions in addition to the anatomic relationship between the tumor and vessels. Neoadjuvant chemotherapy and surgery are associated with improved outcomes of BRPC.

ANNALS OF SURGICAL ONCOLOGY (2021)

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Article Gastroenterology & Hepatology

High CA19-9 level in resectable pancreatic cancer is a potential indication of neoadjuvant treatment

Yuta Ushida et al.

Summary: This study aimed to investigate the prognostic factors for PC patients who underwent upfront resection, finding that the risky-R group had a worse prognosis and higher early recurrence rate. Neoadjuvant chemotherapy should be considered in treatment decision-making for this high-risk group.

PANCREATOLOGY (2021)

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Review Medicine, General & Internal

Pancreatic Cancer: A Review

Wungki Park et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is a relatively uncommon cancer with increasing incidence each year, resulting in a high percentage of patients being diagnosed with advanced disease. Current cytotoxic therapies for PDAC are moderately effective, emphasizing the importance of multidisciplinary management, comprehensive germline testing, and integrated supportive care for all patients.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Gastroenterology & Hepatology

Prognostic significance of preoperative PNI and CA19-9 for pancreatic ductal adenocarcinoma: A multi-institutional retrospective study

Shinji Itoh et al.

Summary: The study revealed that PNI and CA19-9 were significantly associated with poor clinical outcomes in PDAC patients, with lower PNI and higher CA19-9 values correlating with lower survival rates. Combining PNI with CA19-9 enabled better classification of patients based on their clinical outcomes.

PANCREATOLOGY (2021)

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Article Oncology

Pancreatic Adenocarcinoma, Version 2.2021

Margaret A. Tempero et al.

Summary: Pancreatic cancer is the fourth leading cause of cancer-related death in the United States, with a major challenge being advanced disease at diagnosis. While survival rates have not significantly changed, newer treatments, including targeted therapies, offer hope for patients. The manuscript focuses on systemic therapy approaches for locally advanced and metastatic disease.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2021)

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Article Oncology

The Role of CT in Assessment of Extraregional Lymph Node Involvement in Pancreatic and Periampullary Cancer: A Diagnostic Accuracy Study

Dorine S. J. Tseng et al.

Summary: In this study, the diagnostic accuracy of CT in assessing extraregional lymph node metastases in patients with pancreatic or periampullary cancer was found to be low, with a negative predictive value of 80% and a positive predictive value of 31%-33%, and an overall diagnostic accuracy of 69%-70%.

RADIOLOGY-IMAGING CANCER (2021)

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Article Oncology