4.7 Review

Microneedle array patches for allergen- specific immunotherapy

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

Hydrogel-forming microarray patches with solid dispersion reservoirs for transdermal long-acting microdepot delivery of a hydrophobic drug

Yara A. Naser et al.

Summary: This study demonstrates the successful transdermal long-acting delivery of the hydrophobic drug atorvastatin (ATR) via hydrogel-forming microarray patches (HF-MAPs) using poly(ethylene)glycol (PEG)-based solid dispersion (SD) reservoirs.

JOURNAL OF CONTROLLED RELEASE (2023)

Article Chemistry, Multidisciplinary

Development and Evaluation of Dissolving Microarray Patches for Co-administered and Repeated Intradermal Delivery of Long-acting Rilpivirine and Cabotegravir Nanosuspensions for Paediatric HIV Antiretroviral Therapy

Kurtis Moffatt et al.

Summary: This study evaluates the intradermal delivery of long-acting injectable nanosuspensions of RPV LA and CAB LA using self-disabling dissolving microarray patches. The results show that these patches can maintain therapeutically relevant plasma concentrations for an extended period, making them a potential option to improve adherence in the paediatric population.

PHARMACEUTICAL RESEARCH (2023)

Article Pharmacology & Pharmacy

Angled Insertion of Microneedles for Targeted Antigen Delivery to the Epidermis

Rohan Murty et al.

Summary: This study successfully localized antigen delivery to the epidermis using angled insertion of microneedles. Angled insertion significantly reduced microneedle insertion depth and increased epidermal localization of antigen delivery.

PHARMACEUTICS (2022)

Article Immunology

Targeted allergen-specific immunotherapy within the skin improves allergen delivery to induce desensitization to peanut

Jeffrey J. Landers et al.

Summary: This study compared the efficacy of peanut-coated microneedles with peanut epicutaneous immunotherapy (EPIT) in a peanut allergy mouse model. The findings suggest that peanut-coated microneedles are safe and enhance desensitization to peanut.

IMMUNOTHERAPY (2022)

Article Materials Science, Multidisciplinary

Ring inserts as a useful strategy to prepare tip-loaded microneedles for long-acting drug delivery with application in HIV pre-exposure prophylaxis

Alejandro J. Paredes et al.

Summary: Microneedle array patches (MAPs), including dissolving MAPs, play an increasingly important role in transdermal drug delivery for the management of multiple diseases. However, challenges exist in the manufacturing process, such as the presence of bubbles and lack of uniformity in microneedle formation. In this study, a simple method using ring inserts was developed to produce tip-loaded MAPs. The obtained MAPs showed high uniformity in microneedle formation and suitable insertion capability. Pharmacokinetic studies in rats demonstrated that these MAPs could maintain therapeutic plasma levels of the drug for 14 days.

MATERIALS & DESIGN (2022)

Article Nanoscience & Nanotechnology

Conductive Microneedle Patch with Electricity-Triggered Drug Release Performance for Atopic Dermatitis Treatment

Yuan Yang et al.

Summary: In this study, a two-electrode microneedle patch (t-EMNP) was developed for improving the transdermal drug delivery efficacy in the treatment of atopic dermatitis. The drug loading capability and release rate of the microneedles could be controlled by adjusting the polymerization time, drug concentration, and applied voltage. The patch demonstrated remarkable performance of electricity-triggered drug release, effectively delivering more drugs into the skin and alleviating atopic dermatitis.

ACS APPLIED MATERIALS & INTERFACES (2022)

Article Chemistry, Multidisciplinary

Hollow microneedle assisted intradermal delivery of hypericin lipid nanocapsules with light enabled photodynamic therapy against skin cancer

Heba Abd-El-Azim et al.

Summary: Photodynamic therapy (PDT) has emerged as a promising approach for managing non-melanoma skin cancers. In this study, Hy was successfully encapsulated into lipid nanocapsules (Hy-LNCs) and delivered intradermally using AdminPenTM hollow microneedles (Ho-MNs) array. The Hy-LNCs exhibited higher photoactivity, better skin penetration, and significantly enhanced therapeutic effect compared to free Hy.

JOURNAL OF CONTROLLED RELEASE (2022)

Article Chemistry, Multidisciplinary

Hydrogel-forming microarray patches with cyclodextrin drug reservoirs for long-acting delivery of poorly soluble cabotegravir sodium for HIV Pre-Exposure Prophylaxis

Fabiana Volpe-Zanutto et al.

Summary: This article introduces the application of hydrogel-forming microarray patches (HF-MAPs) for minimally invasive, pain-free and prolonged drug delivery. The use of hydroxypropyl-I3-cyclodextrin (HP-I3-CD) to enhance the solubility of cabotegravir sodium (CAB-Na) is studied for the first time, and its effect on intradermal delivery via HF-MAPs is investigated. The results show that the HF-MAPs can effectively deliver CAB-Na drugs both ex vivo and in vivo.

JOURNAL OF CONTROLLED RELEASE (2022)

Article Pharmacology & Pharmacy

Trilayer dissolving polymeric microneedle array loading Rose Bengal transfersomes as a novel adjuvant in early-stage cutaneous melanoma management

Sara Demartis et al.

Summary: The development of a trilayer dissolving microneedle array (RBTF-TDMNs) for efficient intradermal delivery of Rose Bengal towards melanoma management represents a promising approach in cancer treatment.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

Article Chemistry, Medicinal

Enhancing the Transdermal Delivery of ?Next Generation? Variable New Antigen Receptors Using Microarray Patch Technology: a Proof-of-Concept Study

Aaron R. J. Hutton et al.

Summary: Heavy chain only binding proteins, such as VNARs, are potential alternatives to monoclonal antibodies for therapeutic purposes. This study demonstrates that transdermal delivery of VNARs can be enhanced by modifying microarray array patch systems.

JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

Article Pharmacology & Pharmacy

Enhancing intradermal delivery of tofacitinib citrate: Comparison between powder-loaded hollow microneedle arrays and dissolving microneedle arrays

Alvaro Carcamo-Martinez et al.

Summary: Autoimmune-mediated inflammatory skin diseases such as psoriasis, alopecia areata, and vitiligo can significantly impact patients' quality of life. Treatment with systemic steroids is common but may not always be successful. Recent studies have shown promising results with oral Janus Kinase (JAK) inhibitors, although they come with frequent side effects.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Article Chemistry, Multidisciplinary

Dissolving microneedle patches loaded with amphotericin B microparticles for localised and sustained intradermal delivery: Potential for enhanced treatment of cutaneous fungal infections Ke

Ke Peng et al.

Summary: Fungal infections are a global issue affecting millions of individuals, with conventional treatments often proving ineffective due to low drug bioavailability and drug resistance. Amphotericin B (AmB) loaded dissolving microneedle patches were introduced for localized and long-acting intradermal delivery to treat cutaneous fungal infections, demonstrating significant inhibition and killing of Candida albicans. Moreover, pharmacokinetic studies showed lower systemic exposure and reduced systemic side effects compared to intravenous injection, highlighting the potential of this novel drug delivery system.

JOURNAL OF CONTROLLED RELEASE (2021)

Review Pharmacology & Pharmacy

New Therapeutic Approaches for Allergy: A Review of Cell Therapy and Bio- or Nano-Material-Based Strategies

Juan L. Paris et al.

Summary: Allergy is a major health issue with limited treatment options available. Antigen-specific immunotherapy offers long-term control of allergic diseases, but there are concerns regarding ineffective immunotherapies and the risk of adverse reactions during treatment. Therefore, novel therapeutic strategies such as cell therapy and bio- or nano-material-based therapy show promising potential for the future of allergy treatment.

PHARMACEUTICS (2021)

Article Engineering, Biomedical

Epigallocatechin gallate/L-ascorbic acid-loaded poly-γ-glutamate microneedles with antioxidant, anti-inflammatory, and immunomodulatory effects for the treatment of atopic dermatitis

Yu-Hsiu Chiu et al.

Summary: The study shows that poly-gamma-glutamate microneedles can efficiently deliver epigallocatechin gallate into the skin to ameliorate symptoms of atopic dermatitis. This formulation not only protects EGCG from oxidation, but also modulates immune response to relieve allergic reactions, presenting a promising therapeutic option for AD treatment.

ACTA BIOMATERIALIA (2021)

Review Allergy

Advances and highlights in biomarkers of allergic diseases

Ismail Ogulur et al.

Summary: During the past years, there has been a global outbreak of allergic diseases causing significant medical and socioeconomic burden. Type 2 immune response plays a key role in allergic diseases and biomarkers are crucial for precision medicine in diagnosis and treatment. Recent research has focused on identifying new biomarkers for allergic diseases, including sputum eosinophils, serum periostin, and exhaled nitric oxide.

ALLERGY (2021)

Article Pharmacology & Pharmacy

Novel tip-loaded dissolving and implantable microneedle array patches for sustained release of finasteride

Alejandro J. Paredes et al.

Summary: The study developed long-acting dissolving and implantable PLGA MAPs for systemic release of FND for at least two weeks, using micromoulding methodology to obtain mechanically strong tip-loaded MAPs with pyramidal geometry. In vitro studies demonstrated that these patches could release the drug continuously, deposit a certain amount of FND in the skin, and gradually release it into the receptor compartment.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Article Materials Science, Biomaterials

Hydrogel-forming microneedles for rapid and efficient skin deposition of controlled release tip-implants

Ke Peng et al.

Summary: The novel hybrid microneedle patches utilize PLGA tips aligned with hydrogel-forming microneedle bases, improving drug delivery efficiency and insertion speed while ensuring easy removal from the skin. The system shows potential for rapid implantation and sustained release of antifungal drugs for dermal infections.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Article Chemistry, Multidisciplinary

Epicutaneous Allergen Administration with Microneedles as a Novel Method of Immunotherapy for House Dust Mite (HDM) Allergic Rhinitis

Yu-Ji Choi et al.

Summary: Precision delivery of allergens into the skin layer using microneedles can achieve effective immunotherapy for allergic rhinitis.

PHARMACEUTICAL RESEARCH (2021)

Article Allergy

Delivery of allergen powder for safe and effective epicutaneous immunotherapy

Yang Yu et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Article Allergy

Mechanisms of Subcutaneous and updates Sublingual Aeroallergen Immunotherapy: What Is New?

Zsolt Istvan Komlosi et al.

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA (2020)

Article Biochemistry & Molecular Biology

Pullulan-based dissolving microneedle arrays for enhanced transdermal delivery of small and large biomolecules

Lalitkumar K. Vora et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Article Chemistry, Multidisciplinary

Immunogenicity of Milk Protein-Containing Hydrophilic Gel Patch for Epicutaneous Immunotherapy for Milk Allergy

Sayami Ito et al.

PHARMACEUTICAL RESEARCH (2020)

Article Medicine, Research & Experimental

Microneedle-Mediated Allergen-Specific Immunotherapy for the Treatment of Airway Allergy in Mice

Akhilesh Kumar Shakya et al.

MOLECULAR PHARMACEUTICS (2020)

Article Chemistry, Multidisciplinary

Microneedles coated with peanut allergen enable desensitization of peanut sensitized mice

Akhilesh Kumar Shakya et al.

JOURNAL OF CONTROLLED RELEASE (2019)

Article Allergy

Coated microneedle-based cutaneous immunotherapy prevents Der p 1-induced airway allergy in mice

Akhilesh Kumar Shakya et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Article Medicine, Research & Experimental

Assessment of Th1/Th2 Bias of STING Agonists Coated on Microneedles for Possible Use in Skin Allergen Immunotherapy

Akhilesh Kumar Shakya et al.

MOLECULAR PHARMACEUTICS (2018)

Article Allergy

Epicutaneous immunotherapy for the treatment of peanut allergy in children and young adults

Stacie M. Jones et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

Article Chemistry, Multidisciplinary

Cutaneous vaccination with coated microneedles prevents development of airway allergy

Akhilesh Kumar Shakya et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Article Food Science & Technology

Pru p 3-Epitope-based sublingual immunotherapy in a murine model for the treatment of peach allergy

Maria J. Rodriguez et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2017)

Review Immunology

Epidemiology, Mechanisms, and Diagnosis of Drug-Induced Anaphylaxis

Maria Isabel Montanez et al.

FRONTIERS IN IMMUNOLOGY (2017)

Review Allergy

Epicutaneous immunotherapy

S. Scheurer et al.

ALLERGOLOGIA ET IMMUNOPATHOLOGIA (2017)

Review Allergy

Immunoglobulin E, what is it good for?

Brian T. Kelly et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2016)

Article Allergy

Comparison of Microneedles and Adhesive-Tape Stripping in Skin Preparation for Epicutaneous Allergen Delivery

Lara Spina et al.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2015)

Article Allergy

Overview of the immune response

David D. Chaplin

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)