Exploring human CYP4 enzymes: Physiological roles, function in diseases and focus on inhibitors

The cytochrome P450 (CYP)4 family of enzymes are monooxygenases responsible for the x-oxidation of endogenous fatty acids and eicosanoids and play a crucial part in regulating numerous eicosanoid signaling path-ways. Recently, CYP4 gained attention as a potential therapeutic target for several human diseases, including cancer, cardiovascular diseases and inflammation. Small -molecule inhibitors of CYP4 could provide promising treatments for these diseases. The aim of the present review is to highlight the advances in the field of CYP4, discussing the physiology and pathology of the CYP4 family and compiling CYP4 inhibitors into groups based on their chemical classes to provide clues for the future discovery of drug candidates targeting CYP4.

Automated summary

The cytochrome P450 (CYP)4 family of enzymes are responsible for the oxidation of fatty acids and play a crucial role in regulating various signaling pathways. Recent studies have identified CYP4 as a potential therapeutic target for human diseases like cancer, cardiovascular diseases, and inflammation. In this review, the physiological and pathological aspects of the CYP4 family are discussed, and CYP4 inhibitors are categorized based on their chemical classes to aid in the discovery of future drug candidates targeting CYP4.