Bioinformatics Analysis Reveals the Vital Role of AKR1B1 in Immune Infiltration and Clinical Outcomes of Gastric Cancer

Article Multidisciplinary Sciences

Comprehensive analysis of COMMD10 as a novel prognostic biomarker for gastric cancer

Wenfang Zhao et al.

Summary: This study found that COMMD10 was highly expressed in gastric adenocarcinoma (STAD) and was associated with poor prognosis. Additionally, COMMD10 was related to m6A modification and immune infiltration in STAD.

PEERJ (2023)

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Article Oncology

The gene regulatory molecule GLIS3 in gastric cancer as a prognostic marker and be involved in the immune infiltration mechanism

Yi Ding et al.

Summary: GLIS3 is significantly upregulated in gastric cancer and is associated with immune infiltration. High expression of GLIS3 is correlated with adverse prognosis and can serve as a predictive biomarker in gastric cancer patients.

FRONTIERS IN ONCOLOGY (2023)

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Review Gastroenterology & Hepatology

The immune microenvironment in gastric adenocarcinoma

Yana Zavros et al.

Summary: This article reviews the role of the immune microenvironment in the progression of chronic inflammation to gastric adenocarcinoma (GAC), particularly the immune microenvironment driven by Helicobacter pylori infection. The infection-driven nature of most GACs has renewed awareness of the immune microenvironment and its effect on tumor development.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

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Article Genetics & Heredity

Integrative Analysis Identifies a TNFα-Derived Gene Signature for Predicting Prognosis, Tumor Immunity, and Treatment Sensitivity in Gastric Cancer

Ke Wang et al.

Summary: This study conducted an integrative analysis of the role of TNF alpha-derived genes in gastric cancer (GC) prognosis and precision medicine. A TNF alpha-derived gene signature was developed and found to reliably and independently predict GC prognosis. The signature was correlated with clinical features such as histological grades and pathological stages. Additionally, different risk scores were associated with immune and stromal activation.

FRONTIERS IN GENETICS (2022)

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Review Oncology

The Immune Microenvironment in Gastric Cancer: Prognostic Prediction

Mingwei Ma et al.

Summary: This article reviews the recent research progress in prognostic prediction and the immune microenvironment of gastric cancer, and discusses the possibility of new therapeutic targets for gastric cancer.

FRONTIERS IN ONCOLOGY (2022)

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Review Pathology

Epigenetic signatures in gastric cancer: current knowledge and future perspectives

Fatma Sogutlu et al.

Summary: Early diagnosis of gastric cancer is crucial for prognosis, and epigenetic alterations, which occur before most genetic aberrations, play a significant role in its pathogenesis. These alterations can serve as biomarkers for risk calculation, early diagnosis, prognosis evaluation, and treatment targets.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2022)

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Article Oncology

Gastric cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up

F. Lordick et al.

ANNALS OF ONCOLOGY (2022)

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Article Gastroenterology & Hepatology

Nationwide gastric cancer prevention in China, 2021-2035: a decision analysis on effect, affordability and cost-effectiveness optimisation

Zixing Wang et al.

Summary: The study projected a significant burden of gastric cancer in China from 2021 to 2035, with various prevention strategies showing potential to reduce the number of new cases and deaths. Eradication of Helicobacter pylori (Hp) was found to be a cost-saving strategy, while targeted endoscopy screening was more cost-effective compared to general screening. Tailoring screening frequency according to personal risk could also significantly reduce endoscopy-related resources in high-risk populations.

GUT (2022)

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Article Genetics & Heredity

Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment

Dalia Barkley et al.

Summary: This study performs a comprehensive analysis of gene expression in malignant cells of various cancer types using single-cell RNA sequencing. The analysis identifies recurrent cancer cell states and demonstrates the link between interferon response in cancer cells and T cells and macrophages in the tumor microenvironment. Mouse models further confirm the variation in induction of interferon response module based on tumor location and lymphocyte elimination, providing insights into the interaction between cancer cell states and the tumor microenvironment.

NATURE GENETICS (2022)

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Article Pharmacology & Pharmacy

Moving toward a new horizon for the aldose reductase inhibitor epalrestat to treat drug-resistant cancer

Christian Bailly

Summary: Epalrestat (EPA) is a drug that inhibits aldose reductases and shows potential in the treatment of diabetic peripheral neuropathy. It has been found to have significant anticancer effects in experimental models of liver, colon, and breast cancers, and can enhance the sensitivity of cancer cells to chemotherapy drugs. Clinical trials are underway in patients with triple-negative breast cancer.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

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Article Genetics & Heredity

Bioinformatics Analysis and Structure of Gastric Cancer Prognosis Model Based on Lipid Metabolism and Immune Microenvironment

Yongzhi Chen et al.

Summary: Lipid metabolism plays an important role in the tumor immune microenvironment and prognosis of gastric cancer, and a risk model based on lipid metabolism genes can accurately predict the survival of gastric cancer.

GENES (2022)

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Article Medicine, General & Internal

Prognosis and tumor immune microenvironment of patients with gastric cancer by a novel senescence-related signature

Guanglin Zhang et al.

Summary: A senescence-related signature was developed using LASSO and Cox regression analysis, which accurately predicted the prognosis of gastric cancer patients and may promote the progress of personalized treatment.

MEDICINE (2022)

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Review Biochemistry & Molecular Biology

Signaling pathways and therapeutic interventions in gastric cancer

Zi-Ning Lei et al.

Summary: Gastric cancer is the fifth most diagnosed cancer and the fourth leading cause of cancer-related death worldwide. Advancements in genome analysis have identified biomarkers and signaling pathways that play vital roles in gastric cancer development, progression, and treatment response. These discoveries provide a direction for improving gastric cancer diagnosis and treatment.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Review Immunology

Tumour immunotherapy: lessons from predator-prey theory

Phineas T. Hamilton et al.

Summary: This article introduces the application of predator-prey theory to the interaction between immune cells and cancer cells. By revealing the fundamental mechanisms by which antitumour immunity might fail in sometimes counterintuitive ways, it provides a new evidence-based framework to better understand and therapeutically target the immune-cancer interface.

NATURE REVIEWS IMMUNOLOGY (2022)

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Article Oncology

Low CBS expression can identify patients who benefit from adjuvant chemotherapy in gastric cancer

Jinsheng Zhao et al.

Summary: The study revealed that low CBS expression can benefit from ACT in GC, while patients with high CBS expression have poor survival rates after ACT. Furthermore, drug response prediction suggested that patients with low CBS expression are highly sensitive to a certain chemotherapy drug.

EXPERT REVIEW OF ANTICANCER THERAPY (2021)

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Review Cell Biology