Electrochemical detection of dopamine by using nickel supported carbon nanofibers modified screen printed electrode

The detection of the neurotransmitter dopamine in medicinal and human biological samples has attracted the huge interest of researchers in recent years. Carbon nanofiber is a potential nanocarbon material for the detection of dopamine (DA) due to its good electrochemical properties. In this work, carbon nanofiber (CNF) supported nickel nanoparticles (Ni@CNF) were prepared by wet impregnation method and characterized by TEM, EDS, XRD and FTIR analysis. The Ni@CNF modified screen printed electrode gave superior electrochemical response. Moreover, the Ni@/CNF shows a broad linear detection range (0.1-10 mu M), a low detection limit (0.03 mu M) by using DPV analysis and excellent selectivity. The developed electrode shows good reproducibility, stability, and repeatability. The Ni@CNF/SPCE has been also utilized for the detection of DA in pharmaceutical, human blood serum and urine samples with substantial recovery outcomes. Therefore, the prepared CNF@Ni/SPCE will be a capable platform for the electrochemical detection of DA in biological or medicinal samples.

Automated summary

The detection of dopamine in medicinal and human biological samples has become an area of great interest for researchers. Carbon nanofiber (CNF) supported nickel nanoparticles (Ni@CNF) were prepared and characterized for their electrochemical properties. The modified electrode showed superior response, a broad linear detection range, low detection limit, and excellent selectivity. It was also successfully applied for the detection of dopamine in pharmaceutical and biological samples with good recovery outcomes.