Inverse association between glucose variability and body fat in type 2 diabetes with impaired endogenous insulin secretion assessed using continuous glucose monitoring: A prospective observational study

Article Endocrinology & Metabolism

Glucose variability in subjects with normal glucose tolerance: Relations with body composition, insulin secretion and sensitivity

Vadim V. Klimontov et al.

Summary: This study found that in non-obese subjects with NGT, mean glucose and GV parameters are associated with fat mass and fat distribution. These relationships may be mediated through insulin secretion and sensitivity.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2022)

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Article Endocrinology & Metabolism

Impaired insulin secretion predicting unstable glycemic variability and time below range in type 2 diabetes patients regardless of glycated hemoglobin or diabetes treatment

Aika Miya et al.

Summary: The study identified a CV of 40 as the threshold that distinguishes unstable glucose variability and hypoglycemia from stable GV in Japanese outpatients with type 2 diabetes. Impaired insulin secretion might affect the stability of glucose variability.

JOURNAL OF DIABETES INVESTIGATION (2021)

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Review Cardiac & Cardiovascular Systems

Comprehensive elaboration of glycemic variability in diabetic macrovascular and microvascular complications

Bao Sun et al.

Summary: Glycemic variability (GV) is recognized as a possible independent risk factor for diabetic complications, with this review summarizing the metrics and measurement of GV in clinical practice and elaborating its role and related mechanisms in both macrovascular and microvascular complications of diabetes to provide mechanism-based therapeutic strategies for clinicians.

CARDIOVASCULAR DIABETOLOGY (2021)

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Article Endocrinology & Metabolism

Altered hormonal and autonomic nerve responses to hypo- and hyperglycaemia are found in overweight and insulin-resistant individuals and may contribute to the development of type 2 diabetes

Martin H. Lundqvist et al.

Summary: The study found that overweight and insulin-resistant individuals have altered responses of insulin-antagonistic hormones and the autonomic nervous system to glucose fluctuations, which are probably partly mediated by the central nervous system.

DIABETOLOGIA (2021)

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Article Endocrinology & Metabolism

The association between hypoglycemia and glycemic variability in elderly patients with type 2 diabetes: a prospective observational study

Takahisa Handa et al.

Summary: Among elderly patients with type 2 diabetes, the coefficient of variation (CV) is the most appropriate index that best reflects TBR >= 1% among the glycemic variability (GV) indices examined. Clinical characteristics including HbA1c and C-peptide index were not independent markers for TBR >= 1% in the multivariate logistic regression analysis, while all three GV indices showed significant associations with TBR >= 1%.

DIABETOLOGY & METABOLIC SYNDROME (2021)

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Article Multidisciplinary Sciences

Log-linear relationship between endogenous insulin secretion and glycemic variability in patients with type 2 diabetes on continuous glucose monitoring

Aika Miya et al.

Summary: In patients with type 2 diabetes, there is a negative log-linear relationship between fasting C-peptide levels and glycemic variability, with low C-peptide levels being a predictor of high glycemic variability. Endogenous insulin secretion contributes to glycemic variability depending on the extent of insulin secretion impairment. Fasting C-peptide may serve as a useful indicator of glycemic variability instability in type 2 diabetes.

SCIENTIFIC REPORTS (2021)

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Article Endocrinology & Metabolism

Effect of Professional CGM (pCGM) on Glucose Management in Type 2 Diabetes Patients in Primary Care

Gregg D. Simonson et al.

Summary: The study found that using professional CGM in the management of type 2 diabetes, combined with lifestyle counseling and therapy intensification, significantly improved glycemic control, reduced A1C levels, increased time in range, and decreased time in hyperglycemia.

JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY (2021)

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Article Endocrinology & Metabolism