4.7 Article

PATL2 regulates mRNA homeostasis in oocytes by interacting with EIF4E and CPEB1

Related references

Note: Only part of the references are listed.
Article Genetics & Heredity

Novel mutations in NLRP5 and PATL2 cause female infertility characterized by primarily oocyte maturation abnormality and consequent early embryonic arrest

Lingli Huang et al.

Summary: This study aimed to identify genetic causes of primary infertility in 12 women with oocyte maturation abnormality. Novel mutations in NLRP5 and PATL2 were found, expanding the mutational and phenotypic spectrum of both genes. The NLRP5 mutations associated with oocyte maturation abnormality in humans were reported for the first time.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2022)

Review Cell Biology

Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression

Lori A. Passmore et al.

Summary: Recent studies have shown that poly(A) tails play a complex role in the cytoplasm, including promoting translation and controlling mRNA stability through deadenylation. The length of poly(A) tails is correlated with translation rate and mRNA lifespan, indicating a significant role in gene regulation.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

Article Multidisciplinary Sciences

The mechanism of acentrosomal spindle assembly in human oocytes

Tianyu Wu et al.

Summary: This study identified a structure called huoMTOC in human oocytes and revealed its essential role in spindle assembly. The huoMTOC originates beneath the oocyte cortex, migrates near the nuclear envelope, and fragments to initiate microtubule nucleation and spindle assembly.

SCIENCE (2022)

Article Biochemical Research Methods

Transcriptome-wide measurement of poly(A) tail length and composition at subnanogram total RNA sensitivity by PAIso-seq

Yusheng Liu et al.

Summary: Poly(A) tails are added to mRNAs in a non-templated manner and play essential roles in post-transcriptional regulation. Measuring their length is critical for understanding their regulatory roles in biological and medical studies. The PAlso-seq method utilizes PacBio sequencing to accurately measure poly(A) tail length and non-A residues, enabling analysis of samples with limited input material.

NATURE PROTOCOLS (2022)

Article Biochemistry & Molecular Biology

Single Molecule RNA Localization and Translation in the Mammalian Oocyte and Embryo

Denisa Jansova et al.

Summary: This study investigates the subcellular distribution and translation of specific RNAs in oocytes and embryos, revealing instances of localized translation with distinctive regulatory implications. The researchers found that translationally dormant and abundant mRNAs CyclinB1 and Mos are localized in the cytoplasm of fully grown GV oocytes, forming cloud-like structures with abundant translation at the center of MII oocytes. Coupling detection of specific mRNA localization with their translation at the subcellular level is a valuable tool for quantitatively studying temporal and spatial translation of target mRNAs in developing cells.

JOURNAL OF MOLECULAR BIOLOGY (2021)

Article Genetics & Heredity

Novel homozygous mutations in PATL2 lead to female infertility with oocyte maturation arrest

Zhenxing Liu et al.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2020)

Article Multidisciplinary Sciences

Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans

Qian-Qian Sha et al.

NATURE COMMUNICATIONS (2020)

Article Cell Biology

A pannexin 1 channelopathy causes human oocyte death

Qing Sang et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Article Medicine, Research & Experimental

PATL2 is a key actor of oocyte maturation whose invalidation causes infertility in women and mice

Marie Christou-Kent et al.

EMBO MOLECULAR MEDICINE (2018)

Article Obstetrics & Gynecology

Novel mutations in PATL2 cause female infertility with oocyte germinal vesicle arrest

Lingli Huang et al.

HUMAN REPRODUCTION (2018)

Article Biochemistry & Molecular Biology

Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex

Marcello Clerici et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex

Marcello Clerici et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Review Cell Biology

The role of TACC3 in mitotic spindle organization

Zhi-Ming Ding et al.

CYTOSKELETON (2017)

Article Genetics & Heredity

Female Infertility Caused by Mutations in the Oocyte-Specific Translational Repressor PATL2

Sateesh Maddirevula et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2017)

Article Genetics & Heredity

Biallelic Mutations in PATL2 Cause Female Infertility Characterized by Oocyte Maturation Arrest

Biaobang Chen et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2017)

Article Biochemistry & Molecular Biology

BTG4 is a meiotic cell cycle-coupled maternal-zygotic transition licensing factor in oocytes

Chao Yu et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Article Biochemistry & Molecular Biology

BTG4 is a meiotic cell cycle-coupled maternal-zygotic transition licensing factor in oocytes

Chao Yu et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Article Multidisciplinary Sciences

Temporal and spatial regulation of translation in the mammalian oocyte via the mTOR-eIF4F pathway

Andrej Susor et al.

NATURE COMMUNICATIONS (2015)

Review Biochemistry & Molecular Biology

Post-transcriptional and post-translational regulation during mouse oocyte maturation

Min Kook Kang et al.

BMB REPORTS (2011)

Article Biochemistry & Molecular Biology

Pat1 proteins: a life in translation, translation repression and mRNA decay

Aline Marnef et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2010)

Article Developmental Biology

Translational repression by the oocyte-specific protein P100 in Xenopus

Yoriko Nakamura et al.

DEVELOPMENTAL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Human Pat1b Connects Deadenylation with mRNA Decapping and Controls the Assembly of Processing Bodies

Sevim Ozgur et al.

MOLECULAR AND CELLULAR BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Distinct functions of maternal and somatic Pat1 protein paralogs

Aline Marnef et al.

Article Cell Biology

Dcp1-Bodies in Mouse Oocytes

Adam Swetloff et al.

MOLECULAR BIOLOGY OF THE CELL (2009)

Article Biochemistry & Molecular Biology

CPEB interacts with an ovary-specific eIF4E and 4E-T in early Xenopus oocytes

Nicola Minshall et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Multidisciplinary Sciences

Mechanism of degradation of CPEB during Xenopus oocyte maturation

Daiki Setoyama et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Developmental Biology

CPEB controls oocyte growth and follicle development in the mouse

Waldemar J. Racki et al.

DEVELOPMENT (2006)

Article Biochemistry & Molecular Biology

Differential rnRNA translation and rneiotic progression require Cdc2-mediated CPEB destruction

R Mendez et al.

EMBO JOURNAL (2002)

Article Biochemistry & Molecular Biology

A new mathematical model for relative quantification in real-time RT-PCR

MW Pfaffl

NUCLEIC ACIDS RESEARCH (2001)

Article Biochemistry & Molecular Biology

Translational control of embryonic cell division by CPEB and maskin

I Groisman et al.

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY (2001)