☆ 4.0 Review

Cerebrovascular Manifestations of SARS-CoV-2: A Comprehensive Review

CURRENT TREATMENT OPTIONS IN NEUROLOGY (2023)

Related references

Note: Only part of the references are listed.

Review Clinical Neurology

Ischemic stroke associated with COVID-19: a systematic review and meta-analysis

Wenzhang Luo et al.

Summary: Ischemic stroke caused by COVID-19 presents unique clinical features, with hypertension, hyperlipidemia, and diabetes being common risk factors. Both female and at-risk male patients are susceptible. The inflammatory storm of COVID-19 may disproportionately affect male patients, and an increase in cryptogenic stroke is observed.

JOURNAL OF NEUROLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Long-term cardiovascular outcomes of COVID-19

Yan Xie et al.

Summary: Individuals with COVID-19, even those who were not hospitalized during the acute phase of the infection, are at an increased long-term risk of various cardiovascular disorders. A study using national healthcare databases found that beyond the first 30 days after infection, individuals with COVID-19 have an elevated risk of developing cerebrovascular disorders, heart diseases, and other cardiovascular complications. The risk increases depending on the care setting during the acute phase.

NATURE MEDICINE (2022)

Add to Collection

Article Clinical Neurology

Imaging features and ultraearly hematoma growth in intracerebral hemorrhage associated with COVID-19

Andrea Morotti et al.

Summary: This study describes the clinical and imaging features of intracerebral hemorrhage (ICH) in patients with COVID-19. It found that COVID-19 patients with ICH have distinct imaging features and a higher speed of bleeding. This association is not mediated by antithrombotic therapy and further research is needed to characterize the underlying biological mechanisms.

NEURORADIOLOGY (2022)

Add to Collection

Article Neurosciences

Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients

Angela Genchi et al.

Summary: Cerebral thrombi of COVID-19 patients may contain SARS-CoV-2 and are characterized by abnormal immune-thrombotic features, including increased neutrophil number and tNLR.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2022)

Add to Collection

Article Medicine, General & Internal

Association Between Ischemic Stroke and COVID-19 in China: A Population-Based Retrospective Study

Minghuan Wang et al.

Summary: This study found that patients with prior stroke who are hospitalized with COVID-19 have worse clinical outcomes, and COVID-19 increases the incidence of AIS. Patients with prior stroke have a higher risk of developing AIS, and the severity of COVID-19 is positively associated with the incidence of AIS.

FRONTIERS IN MEDICINE (2022)

Add to Collection

Article Clinical Neurology

Systemic thrombolysis in ischaemic stroke patients with COVID-19

Piotr Sobolewski et al.

Summary: The study compared the short-term efficacy and safety of intravenous thrombolysis in COVID-19 infected patients and non-infected patients with acute ischemic stroke. While COVID-19 infection prolonged hospital stay after IVT, it did not have a significant impact on in-hospital outcomes.

ACTA NEUROLOGICA SCANDINAVICA (2022)

Add to Collection

Article Neuroimaging

Mechanical thrombectomy for acute ischemic stroke in COVID-19 patients: multicenter experience in 111 cases

Hanna Styczen et al.

Summary: There is limited data on the frequency and outcome of mechanical thrombectomy (MT) for large vessel occlusion (LVO) in COVID-19 patients. Our multicenter study found that most cases of LVO treated with MT in COVID-19 patients were due to cardioembolic events. While successful reperfusion was achieved in the majority of cases, there was a significant rate of procedure-related complications and poor clinical outcomes, with a high mortality rate.

JOURNAL OF NEUROINTERVENTIONAL SURGERY (2022)

Add to Collection

Article Clinical Neurology

Reversible Cerebral Vasoconstriction Syndrome and Multisystem Inflammatory Syndrome in Children With COVID-19

Atefeh Sadeghizadeh et al.

Summary: This study reported two cases of pediatric COVID-19 patients with severe MIS-C and RCVS. Both patients presented with thunderclap headaches and neurological deficits, and showed marked improvement after treatment.

PEDIATRIC NEUROLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates

Ibolya Rutkai et al.

Summary: COVID-19 infection can lead to neurological manifestations, and animal models can provide insights into the underlying mechanisms. In this study, neuroinflammation, microhemorrhages, and brain hypoxia were observed in SARS-CoV-2 infected non-human primates, even in those without severe respiratory disease. These findings are important for understanding the neuropathogenesis of SARS-CoV-2 infection and may help explain the neurological symptoms associated with long COVID.

NATURE COMMUNICATIONS (2022)

Add to Collection

Editorial Material Pharmacology & Pharmacy

Long-Term Cardiovascular and Cerebrovascular Challenges Posed by COVID-19 in Patients With Familial Hypercholesterolemia

Alpo Vuorio et al.

FRONTIERS IN PHARMACOLOGY (2022)

Add to Collection

Review Medicine, Research & Experimental

Cerebral microvascular complications associated with SARS-CoV-2 infection: How did it occur and how should it be treated?

Neda Omidian et al.

Summary: This review discusses cerebral microvascular disease associated with SARS-CoV-2 infection, which may be due to endothelial cell dysfunction as a part of the blood-brain barrier, accompanied by inflammatory response and blood coagulation disorders.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Add to Collection

Article Medicine, General & Internal

Long-term cardiovascular outcomes in COVID-19 survivors among non-vaccinated population: A retrospective cohort study from the TriNetX US collaborative networks

Weijie Wang et al.

Summary: This study investigates the long-term cardiovascular outcomes in COVID-19 survivors and finds that they have an increased risk of stroke, arrhythmia, inflammatory heart disease, ischemic heart disease, other cardiac disorders, and thromboembolic disorders. These risks are evident in both male and female survivors, and the elderly survivors have a higher risk of mortality. The impact of COVID-19 on cardio-related outcomes appears to be more pronounced in inpatients.

ECLINICALMEDICINE (2022)

Add to Collection

Review Clinical Neurology

Incidence of Stroke in Randomized Trials of COVID-19 Therapeutics: A Systematic Review and Meta-Analysis

Sanjana Nagraj et al.

Summary: This study aims to assess the risk of stroke in patients with COVID-19. By analyzing randomized controlled studies, it was concluded that the overall incidence of stroke in patients with COVID-19 appears to be lower, especially in outpatient settings.

STROKE (2022)

Add to Collection

Article Clinical Neurology

COVID-19-related strokes are associated with increased mortality and morbidity: A multicenter comparative study from Bengaluru, South India

Thomas Mathew et al.

Summary: COVID-19-related strokes are increasingly diagnosed worldwide. This study describes 62 cases of COVID-19-related stroke patients from 13 hospitals in south India, showing that most cases were ischemic strokes and patients often had traditional stroke risk factors. Treatments included intravenous thrombolysis and mechanical thrombectomy.

INTERNATIONAL JOURNAL OF STROKE (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

Risk factors for intracerebral hemorrhage in patients with COVID-19

Kara R. Melmed et al.

Summary: This study assessed risk factors associated with intracerebral hemorrhage in COVID-19 patients, finding that anticoagulation use was linked to an increased risk of intracerebral hemorrhage and was associated with higher mortality. Further investigation is needed to understand the underlying mechanisms and develop prevention strategies in this population.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2021)

Add to Collection

Article Critical Care Medicine

Anticoagulation use and Hemorrhagic Stroke in SARS-CoV-2 Patients Treated at a New York Healthcare System

Alexandra Kvernland et al.

Summary: While thrombotic complications of COVID-19 have been extensively studied, limited data exists on hemorrhagic stroke. This retrospective study in New York found most hemorrhages in COVID-19 patients occurred in the setting of therapeutic anticoagulation and were associated with increased mortality. Further research is needed to evaluate the safety and efficacy of therapeutic anticoagulation in COVID-19 patients.

NEUROCRITICAL CARE (2021)

Add to Collection

Article

Role of neuroimaging in COVID 19 infection – Retrospective Study

Tushar Kalekar et al.

Journal of Radiology Nursing (2021)

Add to Collection

Article Clinical Neurology

Pediatric Ischemic Stroke: An Infrequent Complication of SARS-CoV-2

Lauren A. Beslow et al.

Summary: This study aimed to determine the proportion of pediatric SARS-CoV-2 cases with ischemic stroke and found that only a small percentage of pediatric SARS-CoV-2 cases develop stroke, with a low proportion testing positive for SARS-CoV-2.

ANNALS OF NEUROLOGY (2021)

Add to Collection

Article Clinical Neurology

The Impact of SARS-CoV-2 on Stroke Epidemiology and Care: A Meta-Analysis

Aristeidis H. Katsanos et al.

Summary: This study found that patients with SARS-CoV-2 infection have an increased risk of ischemic stroke and higher mortality rates.

ANNALS OF NEUROLOGY (2021)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

Spectrum of neuroimaging findings in COVID-19

Ahmed H. El Beltagi et al.

Summary: After the outbreak of COVID-19, various neurological complications were observed in hospitalized patients, including cerebrovascular diseases, encephalitis, and spinal manifestations.

BRITISH JOURNAL OF RADIOLOGY (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

Long COVID: long-term effects?

Alessandro Di Toro et al.

Summary: Long COVID, characterized by persistence of symptoms for at least 12 weeks after COVID-19 onset, presents a clinically heterogeneous condition with involvement of multiple organs/systems, including the cardiovascular system. Recurrent symptoms include fatigue, breathlessness, myalgia, headache, and impaired concentration, with potential cardiovascular manifestations such as palpitations and chest pain. Diagnostic criteria remain narrative-based with a need for shared diagnostic framework integrating biomarkers, imaging, and clinical monitoring for at-risk patients.

EUROPEAN HEART JOURNAL SUPPLEMENTS (2021)

Add to Collection

Letter Clinical Neurology

Intracerebral endotheliitis and microbleeds are neuropathological features of COVID-19

Daniel Kirschenbaum et al.

Summary: Cerebral microhemorrhages in COVID-19 patients may be the result of Sars-CoV-2-induced endotheliitis and more general vasculopathic changes, possibly correlating with an increased risk of vascular encephalopathy. This pathological condition was confirmed in autopsies, but further research is needed to understand the specific causes and mechanisms.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2021)

Add to Collection

Letter Medicine, General & Internal

Microvascular Injury in the Brains of Patients with Covid-19

Daniel P. Perl et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Add to Collection

Article Clinical Neurology

European Multicenter Study of ET-COVID-19

Federico Cagnazzo et al.

Summary: The study found that the 30-day mortality rate after MT in COVID-19 patients was 29%, and abnormalities in lymphocyte count, LDH, and aspartate levels may indicate poorer outcomes. The rate of symptomatic intracranial hemorrhage was 5.4%.

STROKE (2021)

Add to Collection

Article Clinical Neurology

Acute Cerebrovascular Events With COVID-19 Infection

Mandip S. Dhamoon et al.

Summary: COVID-19 patients with stroke are more likely to have a cryptogenic cause, experience ischemic stroke in specific regions, and have worse outcomes compared to non-COVID-19 patients.

STROKE (2021)

Add to Collection

Editorial Material Medicine, General & Internal

Managing the long term effects of covid-19: summary of NICE, SIGN, and RCGP rapid guideline

Waqaar Shah et al.

BMJ-BRITISH MEDICAL JOURNAL (2021)

Add to Collection

Article Critical Care Medicine

Higher anticoagulation targets and risk of thrombotic events in severe COVID-19 patients: bi-center cohort study

Julie Helms et al.

Summary: Using therapeutic anticoagulation in COVID-19 patients may decrease thrombotic complications without increasing bleeding risk, potentially improving survival rates.

ANNALS OF INTENSIVE CARE (2021)

Add to Collection

Article Neurosciences

Reversible Cerebral Vasoconstriction Syndrome in Patients with Coronavirus Disease: A Multicenter Case Series

Kristine Arandela et al.

Summary: This study describes the clinical features, risk factors, and outcomes of RCVS in a group of COVID-19 patients. The findings suggest that COVID-19 patients may be at risk for developing RCVS, especially with additional risk factors such as exposure to vasoactive agents. There was variability in symptoms and severity of COVID-19, clinical characteristics, imaging abnormalities, and mRS scores among the patients with RCVS.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2021)

Add to Collection

Article Neurosciences

Do Elevated Levels of Inflammatory Biomarkers Predict the Risk of Occurrence of Ischemic Stroke in SARS-CoV2?: An Observational Study

Nitisha Goyal et al.

Summary: This study aimed to analyze the factors associated with the occurrence of stroke in SARS-CoV2 patients, finding that elevated levels of D-dimer, erythrocyte sedimentation rate (ESR), and red cell distribution width (RDW) were significantly associated with stroke occurrence, while traditional cardiovascular disease risk factors were not strong predictors of stroke.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2021)

Add to Collection

Article Clinical Neurology

Stroke etiologies in patients with COVID-19: the SVIN COVID-19 multinational registry

Maria E. Ramos-Araque et al.

Summary: This study evaluated clinical predictors of cryptogenic stroke, short-term functional outcomes, and in-hospital mortality among patients with COVID-19 associated stroke. Among 14,483 laboratory-confirmed COVID-19 patients, 1.1% were diagnosed with acute ischemic stroke, with cryptogenic stroke being the most frequently reported etiology.

BMC NEUROLOGY (2021)

Add to Collection

Article Neurosciences

SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein

Rayan Khaddaj-Mallat et al.

Summary: COVID-19, caused by SARS-CoV-2, induces vascular-mediated neurological disorders via elusive mechanisms. Brain pericytes respond to the exposure of S protein by increasing ACE2 expression and undergoing phenotypic changes, impacting vascular and immune regulatory functions which may contribute to brain damage.

NEUROBIOLOGY OF DISEASE (2021)

Add to Collection

Review Neurosciences

Cerebral Venous Sinus Thrombosis in COVID-19 Patients: A Multicenter Study and Review of Literature

Mohamad Abdalkader et al.

Summary: COVID-19 infection can predispose patients to both arterial and venous thromboembolic events, including CVST. Reviewing the clinical and radiological presentation of CVST in COVID-19 positive patients revealed that patients often presented with symptoms like headache, fever, and gastrointestinal symptoms. Clinicians should be vigilant about the risk of acute CVST in patients positive for COVID-19.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2021)

Add to Collection

Article Medicine, General & Internal

Pathogeny of cerebral venous thrombosis in SARS-Cov-2 infection Case reports

Cecile Guendouz et al.

Summary: The pathogenesis of thrombosis in COVID-19 is related to the interaction between SARS-Cov-2 and the vascular wall through the ACE2 receptor. This leads to immunothrombosis and an increase in angiotensin II levels. While thrombosis is common in severe COVID-19 cases, cerebrovascular diseases such as cerebral venous thrombosis remain rare.

MEDICINE (2021)

Add to Collection

Article Clinical Neurology

Acute Ischemic Stroke and COVID-19 An Analysis of 27 676 Patients

Adnan Qureshi et al.

Summary: Acute ischemic stroke is rare in patients with COVID-19 and is usually accompanied by other cardiovascular risk factors. The risk of discharge to a destination other than home or death doubles with the occurrence of acute ischemic stroke in patients with COVID-19.

STROKE (2021)

Add to Collection

Article Clinical Neurology

Risk, Clinical Course, and Outcome of Ischemic Stroke in Patients Hospitalized With COVID-19 A Multicenter Cohort Study

Wouter M. Sluis et al.

Summary: This study assessed the incidence, risk factors, and outcomes of acute ischemic stroke in hospitalized COVID-19 patients, revealing that stroke patients had a higher risk of in-hospital mortality and an association with pulmonary embolism.

STROKE (2021)

Add to Collection

Letter Hematology

Sustained prothrombotic changes in COVID-19 patients 4 months after hospital discharge

Fien A. von Meijenfeldt et al.

BLOOD ADVANCES (2021)

Add to Collection

Letter Clinical Neurology

Ischemic Stroke in COVID-19 Patients May Be Incidentally but Not Causally Related to the Infection

Josef Finsterer et al.

CEREBROVASCULAR DISEASES (2021)

Add to Collection

Article Medicine, Research & Experimental

Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations

Yuanyuan Qin et al.

Summary: The study found that COVID-19 patients showed severe changes in gray matter, white matter, and cerebral blood flow, especially in patients with severe disease. These changes were significantly correlated with inflammatory markers, suggesting that the inflammatory storm may cause indirect brain damage.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Add to Collection

Article Neurosciences

Intracranial Hemorrhage in COVID-19 Patients

Sanskriti Mishra et al.

Summary: COVID-19 associated intracranial hemorrhage is often linked to at least one known risk factor for hemorrhage and severe pneumonia. There was a notable increase in intracranial hemorrhage cases among all strokes during the peak of the COVID-19 pandemic in NYC, followed by a gradual decrease. Systolic blood pressure variability and neutrophil-to-lymphocyte ratio were moderately and weakly positively correlated with discharge modified Rankin Scale.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2021)

Add to Collection

Review Cardiac & Cardiovascular Systems

Prevalence of Atrial Fibrillation and Associated Mortality Among Hospitalized Patients With COVID-19: A Systematic Review and Meta-Analysis

Zuwei Li et al.

Summary: The prevalence of atrial fibrillation in patients with COVID-19 is around 11%, with higher rates in older and severe cases. Atrial fibrillation and new-onset atrial fibrillation are independently associated with an increased risk of all-cause mortality among hospitalized patients with COVID-19.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Add to Collection

Article Clinical Neurology

Incidence, Characteristics and Outcomes of Large Vessel Stroke in COVID-19 Cohort: An International Multicenter Study

Priyank Khandelwal et al.

Summary: This international study explores the incidence of acute ischemic stroke in COVID-19 patients across 9 stroke centers, with a focus on large vessel occlusion cases. The study reveals that LVO occurs at a significantly younger age in patients with COVID-19, particularly affecting African Americans in the USA.

NEUROSURGERY (2021)

Add to Collection

Article Clinical Neurology

Transcranial Doppler in Acute COVID-19 Infection Unexpected Associations

Wendy C. Ziai et al.

Summary: In critically ill patients with COVID-19 infection, lower than expected cerebral blood flow velocities were observed despite low arterial oxygen content and hematocrit, not associated with suppression of cardiac output. Higher levels of C-reactive protein were positively correlated with blood flow velocities.

STROKE (2021)

Add to Collection

Article Clinical Neurology

SARS-CoV-2 and Stroke Characteristics A Report From the Multinational COVID-19 Stroke Study Group

Shima Shahjouei et al.

Summary: This multinational observational study found that SARS-CoV-2 infected patients had a higher rate of acute ischemic stroke, intracranial hemorrhage, and cerebral venous or sinus thrombosis. Compared to pre-pandemic population studies, these patients also had a significantly higher rate of large vessel occlusions, lower rate of small vessel occlusion, and lacunar infarction, as well as a considerable number of young stroke patients. Additionally, countries with lower health expenditures had a significantly lower rate of mechanical thrombectomy.

STROKE (2021)

Add to Collection

Article Peripheral Vascular Disease

Effect of aspirin on short-term outcomes in hospitalized patients with COVID-19

Aditya Sahai et al.

Summary: The study found that aspirin and NSAIDs did not affect mortality rates or prevent thrombosis in patients with COVID-19. Further investigation is needed to understand the mechanisms of thrombosis in COVID-19 and the role of platelets in mediating this process.

VASCULAR MEDICINE (2021)

Add to Collection

Article Clinical Neurology

Subarachnoid Hemorrhage and COVID-19: An Analysis of 282,718 Patients

Adnan I. Qureshi et al.

Summary: The risk of subarachnoid hemorrhage in patients with COVID-19 was not found to be increased, but their mortality rate was significantly higher, likely due to the higher frequency of systemic comorbidities.

WORLD NEUROSURGERY (2021)

Add to Collection

Article Clinical Neurology

Clinical and Radiological Characteristics of Acute Cerebrovascular Diseases Among Egyptian Patients With COVID-19 in Upper Egypt

Eman M. Khedr et al.

Summary: In Egypt, the proportion of acute cerebrovascular disease among COVID-19 patients is relatively high, with large vessel occlusion being the most common. Hypertension, ischemic heart disease, and anemia are the most common risk factors, while comorbidities are prevalent, including elevated liver enzymes and creatinine partially due to COVID-19 infection itself.

FRONTIERS IN NEUROLOGY (2021)

Add to Collection

Article Medicine, General & Internal

Acute Ischemic Stroke During the Convalescent Phase of Asymptomatic COVID-2019 Infection in Men

Tian Ming Tu et al.

Summary: This case series highlights the increased risk of acute ischemic stroke in male patients aged 50 years or younger during the convalescent phase of asymptomatic COVID-19 infection. The study suggests the importance of monitoring stroke risk and conducting serological testing in these patients to prevent potential complications.

JAMA NETWORK OPEN (2021)

Add to Collection

Article Medicine, General & Internal

Effect of Continuous Infusion of Hypertonic Saline vs Standard Care on 6-Month Neurological Outcomes in Patients With Traumatic Brain Injury: The COBI Randomized Clinical Trial

Antoine Roquilly et al.

Summary: This clinical trial conducted in France explores whether continuous infusion of hypertonic saline solution improves neurological outcome at 6 months in patients with traumatic brain injury.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Add to Collection

Article Neurosciences

COVID-19 Associated Reversible Cerebral Vasoconstriction Syndrome Successfully Treated with Nimodipine and Aspirin

Tarab Mansoor et al.

Summary: Limited cases show a link between SARS-CoV-2 infection and reversible cerebral vasoconstriction syndrome (RCVS). Treatment for RCVS in the context of mild SARS-CoV-2 respiratory infection includes nimodipine and aspirin, as SARS-CoV-2 attacks ACE2 receptors, leading to vasoconstriction.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2021)

Add to Collection

Article Neurosciences

Safety and Outcomes of Intravenous Thrombolytic Therapy in Ischemic Stroke Patients with COVID-19: CASCADE Initiative

Payam Sasanejad et al.

Summary: This multicenter study found that the use of IV-tPA for acute ischemic stroke in COVID-19 patients did not increase the risks of disability, mortality, and hemorrhagic transformation compared to those without COVID-19.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2021)

Add to Collection

Editorial Material Cardiac & Cardiovascular Systems

Cerebral Venous Sinus Thrombosis in the US Population, After Adenovirus-Based SARS-CoV-2 Vaccination, and After COVID-19

Behnood Bikdeli et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

Add to Collection

Letter Clinical Neurology

Intracerebral Hemorrhage in Patients With COVID-19 An Analysis From the COVID-19 Cardiovascular Disease Registry

Audrey C. Leasure et al.

STROKE (2021)

Add to Collection

Article Clinical Neurology

Biomarkers of Coagulation and Inflammation in COVID-19-Associated Ischemic Stroke

Charles Esenwa et al.

Summary: By analyzing biomarkers of inflammation and coagulation, the study found that COVID-19-associated ischemic stroke may be related to the severity of COVID-19 illness and an increasing burden of D-dimer.

STROKE (2021)

Add to Collection

Review Clinical Neurology

2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association

Dawn O. Kleindorfer et al.

Summary: Additional digital content is available in the text.

STROKE (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

Age and Acute Ischemic Stroke Outcome in North American Patients With COVID-19

Adam A. Dmytriw et al.

Summary: The study evaluated the impact of age on functional outcomes and mortality of patients with acute ischemic stroke (AIS) in the context of COVID-19. Results showed that younger patients were more likely to have favorable functional outcomes and lower mortality rates.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

Add to Collection

Article Cell Biology

Neuropathology and Inflammatory Cell Characterization in 10 Autoptic COVID-19 Brains

Daniele Colombo et al.

Summary: COVID-19 infection has a wide range of neurological manifestations, affecting both the central and peripheral nervous system, leading to smell and taste disturbances, cerebrovascular disease, and long-lasting neurological symptoms in surviving patients. Post-mortem neuropathological studies have shown vascular changes, inflammation, and hypoxic neuronal injury in the cerebral cortex of COVID-19 patients, highlighting the role of microvascular injury in neurological manifestations.

CELLS (2021)

Add to Collection

Article Hematology

American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: May 2021 update on the use of intermediate-intensity anticoagulation in critically ill patients

Adam Cuker et al.

Summary: The American Society of Hematology (ASH) guidelines recommend prophylactic-intensity anticoagulation over intermediate-intensity anticoagulation in critically ill patients with COVID-19 who do not have confirmed or suspected VTE. The recommendation was based on low certainty evidence, highlighting the need for more high-quality randomized controlled trials to compare different intensities of anticoagulation in critically ill patients. Other key research priorities include better evidence on predictors of thrombosis and bleeding risk in critically ill patients with COVID-19, as well as the impact of nonanticoagulant therapies on thrombotic risk.

BLOOD ADVANCES (2021)

Add to Collection

Letter Medicine, General & Internal

Atrial arrhythmia and its association with COVID-19 outcome: a pooled analysis

Eka Prasetya Budi Mulia et al.

DIAGNOSIS (2021)

Add to Collection

Article Peripheral Vascular Disease

Cerebral Venous Thrombosis Associated with COVID-19 Infection: An Observational, Multicenter Study

Sajid Hameed et al.

Summary: COVID-19-related CVT is more common in males and older patients compared to non-COVID-19-related cases. Suspect CVT in COVID-19 patients presenting with headache or seizures. Although the mortality rate is high, survivors have good neurological outcomes.

CEREBROVASCULAR DISEASES EXTRA (2021)

Add to Collection

Review Biochemistry & Molecular Biology

The signal pathways and treatment of cytokine storm in COVID-19

Lan Yang et al.

Summary: The COVID-19 pandemic is a global crisis with devastating effects, where immunopathology plays a crucial role in disease progression, particularly the cytokine storm which has a significant impact on prognosis. Understanding and targeting the pathways involved in cytokine storm could lead to more effective treatment strategies for COVID-19.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Add to Collection

Article Medicine, General & Internal

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China

Dawei Wang et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Add to Collection

Article Medicine, General & Internal

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

Roujian Lu et al.

LANCET (2020)

Add to Collection

Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

Add to Collection

Article Multidisciplinary Sciences

A new coronavirus associated with human respiratory disease in China

Fan Wu et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou et al.

NATURE (2020)

Add to Collection

Review Hematology

Broadening the Categories of Patients Eligible for Extended Venous Thromboembolism Treatment

Marc Schindewolf et al.

THROMBOSIS AND HAEMOSTASIS (2020)

Add to Collection

Review Emergency Medicine

Cardiovascular complications in COVID-19

Brit Long et al.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2020)

Add to Collection

Letter Cardiac & Cardiovascular Systems

The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2

Liang Chen et al.

CARDIOVASCULAR RESEARCH (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

Alexandra C. Walls et al.

CELL (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

Description and Proposed Management of the Acute COVID-19 Cardiovascular Syndrome

Nicholas S. Hendren et al.

CIRCULATION (2020)

Add to Collection

Article Infectious Diseases

First case of COVID-19 complicated with fulminant myocarditis: a case report and insights

Jia-Hui Zeng et al.

INFECTION (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

Recommendations on antithrombotic treatment during the COVID-19 pandemic. Position statement of the Working Group on Cardiovascular Thrombosis of the Spanish Society of Cardiology

David Vivas et al.

REVISTA ESPANOLA DE CARDIOLOGIA (2020)

Add to Collection

Article Clinical Neurology

SARS-CoV-2 and Stroke in a New York Healthcare System

Shadi Yaghi et al.

STROKE (2020)

Add to Collection

Article Neurosciences

Hemorrhagic stroke and anticoagulation in COVID-19

Siddhant Dogra et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2020)

Add to Collection

Review Cardiac & Cardiovascular Systems

COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow

Behnood Bikdeli et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

Add to Collection

Article Hematology

Macrothrombosis and stroke in patients with mild Covid-19 infection

Michael G. Fara et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

Add to Collection

Article Hematology

ISTH interim guidance on recognition and management of coagulopathy in COVID-19

Jecko Thachil et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

Add to Collection

Article Medicine, General & Internal

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Fei Zhou et al.

LANCET (2020)

Add to Collection

Article Critical Care Medicine

Guidelines for the Acute Treatment of Cerebral Edema in Neurocritical Care Patients

Aaron M. Cook et al.

NEUROCRITICAL CARE (2020)

Add to Collection

Article Clinical Neurology

Dual versus mono antiplatelet therapy for acute non- cardio embolic ischemic stroke or transient ischemic attack, an efficacy and safety analysis - updated meta-analysis

Christessa Emille Que Albay et al.

BMC NEUROLOGY (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

COVID-19 and cardiac arrhythmias

Anjali Bhatla et al.

HEART RHYTHM (2020)

Add to Collection

Article Clinical Neurology

Risk of Ischemic Stroke in Patients With Coronavirus Disease 2019 (COVID-19) vs Patients With Influenza

Alexander E. Merkler et al.

JAMA NEUROLOGY (2020)

Add to Collection

Article Clinical Neurology

Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study

Yanan Li et al.

STROKE AND VASCULAR NEUROLOGY (2020)

Add to Collection

Letter Critical Care Medicine

Poor survival with extracorporeal membrane oxygenation in acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19): Pooled analysis of early reports

Brandon Michael Henry et al.

JOURNAL OF CRITICAL CARE (2020)

Add to Collection

Article Clinical Neurology

COVID-19 related neuroimaging findings: A signal of thromboembolic complications and a strong prognostic marker of poor patient outcome

Rajan Jain et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

Incidence and consequences of systemic arterial thrombotic events in COVID-19 patients

Estefania Cantador et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2020)

Add to Collection

Letter Clinical Neurology

Letter: May Cooler Heads Prevail During a Pandemic: Stroke in COVID-19 Patients or COVID-19 in Stroke Patients?

Ali M. Alawieh et al.

NEUROSURGERY (2020)

Add to Collection

Article Clinical Neurology

COVID-19 and Decompressive Hemicraniectomy for Acute Ischemic Stroke

John W. Liang et al.

STROKE (2020)

Add to Collection

Article Clinical Neurology

Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke The Global COVID-19 Stroke Registry

George Ntaios et al.

STROKE (2020)

Add to Collection

Article Clinical Neurology

Acute Cerebrovascular Events in Hospitalized COVID-19 Patients

Aaron Rothstein et al.

STROKE (2020)

Add to Collection

Article Hematology

Incidence of thrombotic complications in critically ill ICU patients with COVID-19

F. A. Klok et al.

THROMBOSIS RESEARCH (2020)

Add to Collection

Article Hematology

Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy

Corrado Lodigiani et al.

THROMBOSIS RESEARCH (2020)

Add to Collection

News Item Medicine, General & Internal

As Their Numbers Grow, COVID-19 Long Haulers Stump Experts

Rita Rubin

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Add to Collection

Article Clinical Neurology

Arterial and venous strokes in the setting of COVID-19

Mohammed F. Kananeh et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2020)

Add to Collection

Letter Clinical Neurology

Letter: Dismantling the Apocalypse Narrative: The Myth of the COVID-19 Stroke

Aaron Miller et al.

NEUROSURGERY (2020)

Add to Collection

News Item Medicine, General & Internal

Long covid: How to define it and how to manage it

Nikki Nabavi

BMJ-BRITISH MEDICAL JOURNAL (2020)

Add to Collection

Article Geriatrics & Gerontology

COVID-19-Related Intracerebral Hemorrhage

Valentin Pavlov et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

Add to Collection

Article Medicine, General & Internal

Risk of stroke in hospitalized SARS-CoV-2 infected patients: A multinational study

Shima Shahjouei et al.

EBIOMEDICINE (2020)

Add to Collection

Article Clinical Neurology

Ischemic Stroke Occurs Less Frequently in Patients With COVID-19 A Multicenter Cross-Sectional Study

Kimon Bekelis et al.

STROKE (2020)

Add to Collection

Article Clinical Neurology

Cerebral microhaemorrhage in COVID-19: a critical illness related phenomenon?

Luke Dixon et al.

STROKE AND VASCULAR NEUROLOGY (2020)

Add to Collection

Article Neurosciences

Characteristics of a Diverse Cohort of Stroke Patients with SARS-CoV-2 and Outcome by Sex

G. Trifan et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2020)

Add to Collection

Review Immunology

The trinity of COVID-19: immunity, inflammation and intervention

Matthew Zirui Tay et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Add to Collection

Review Immunology

Short- and potential long-term adverse health outcomes of COVID-19: a rapid review

T. Y. M. Leung et al.

EMERGING MICROBES & INFECTIONS (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

Antithrombotic Therapy to Prevent Recurrent Strokes in Ischemic Cerebrovascular Disease JACC Scientific Expert Panel

Victor J. Del Brutto et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

Add to Collection

Review Microbiology

Origin and evolution of pathogenic coronaviruses

Jie Cui et al.

NATURE REVIEWS MICROBIOLOGY (2019)

Add to Collection

Review Clinical Neurology

Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association

William J. Powers et al.

STROKE (2019)

Add to Collection

Article Medicine, General & Internal

Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials

Peter M. Bothwell et al.

LANCET (2018)

Add to Collection

Article Medicine, General & Internal

Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA

S. Claiborne Johnston et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Add to Collection

Article Medicine, General & Internal

Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness

Alex C. Spyropoulos et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Add to Collection

Article Hematology

Efficacy and safety of extended thromboprophylaxis for medically ill patients A meta-analysis of randomised controlled trials

Francesco Dentali et al.

THROMBOSIS AND HAEMOSTASIS (2017)

Add to Collection

Article Multidisciplinary Sciences

Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection

Qi Wu et al.

SCIENTIFIC REPORTS (2017)

Add to Collection

Review Clinical Neurology

Reversible Cerebral Vasoconstriction Syndrome: Recognition and Treatment

Cecilia Cappelen-Smith et al.

CURRENT TREATMENT OPTIONS IN NEUROLOGY (2017)

Add to Collection

Article Medicine, General & Internal

Posterior reversible encephalopathy syndrome(PRES)

Sreenivasa Rao Sudulagunta et al.

OXFORD MEDICAL CASE REPORTS (2017)

Add to Collection

Article Medicine, General & Internal

Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study

Martin J. O'Donnell et al.

LANCET (2016)

Add to Collection

Article Medicine, General & Internal

Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients

Alexander T. Cohen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Add to Collection

Article Cardiac & Cardiovascular Systems

Combination of the Immune Modulator Fingolimod With Alteplase in Acute Ischemic Stroke A Pilot Trial

Zilong Zhu et al.

CIRCULATION (2015)

Add to Collection

Letter Medicine, General & Internal

Rivaroxaban for Thromboprophylaxis in Acutely Ill Medical Patients REPLY

Alexander T. Cohen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Add to Collection

Review Rheumatology

Multifaceted effects of hydroxychloroquine in human disease

Nancy J. Olsen et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2013)

Add to Collection

Article Medicine, General & Internal

Rivaroxaban for Thromboprophylaxis in Acutely Ill Medical Patients

Alexander T. Cohen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Add to Collection

Article Medicine, General & Internal

Secondary Prevention after Ischemic Stroke or Transient Ischemic Attack

Stephen M. Davis et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Add to Collection

Article Medicine, General & Internal

Extended-Duration Venous Thromboembolism Prophylaxis in Acutely III Medical Patients With Recently Reduced Mobility

Russell D. Hull et al.

ANNALS OF INTERNAL MEDICINE (2010)

Add to Collection

Article Virology

ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia

HP Jia et al.

JOURNAL OF VIROLOGY (2005)

Add to Collection

Article Medicine, General & Internal

Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial

HC Diener et al.

LANCET (2004)

Add to Collection

Article Oncology

Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis

I Hamming et al.

JOURNAL OF PATHOLOGY (2004)

Add to Collection

Article Multidisciplinary Sciences

Angiotensin-converting enzyme 2 is an essential regulator of heart function

MA Crackower et al.

NATURE (2002)

Add to Collection

Article Medicine, General & Internal

A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke

JP Mohr et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)

Add to Collection

© Peeref 2019-2024. All rights reserved.