4.4 Review

PD-1/PD-L1 Blockade Accelerates the Progression of Atherosclerosis in Cancer Patients

Related references

Note: Only part of the references are listed.
Article Cardiac & Cardiovascular Systems

Atherosclerotic Progression Is Related to Immune-Related Adverse Events

Atsumasa Kurozumi et al.

Summary: ICIs may exacerbate the progression of atherosclerosis, particularly in patients with immune-related adverse events. High-risk cardiovascular patients should be concerned about cardiovascular events. The volume of calcified plaques may be a potential predictor for IRAEs.

INTERNATIONAL HEART JOURNAL (2022)

Review Cardiac & Cardiovascular Systems

ICIs-Related Cardiotoxicity in Different Types of Cancer

Mei Dong et al.

Summary: ICIs have shown great potential in cancer treatment, but their cardiotoxicity is a concerning issue. This systematic review reveals that cardiotoxicity related to ICIs varies with different types of cancer, suggesting the importance of personalized clinical strategies to maintain the cardiovascular health of cancer patients.

JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE (2022)

Review Cell Biology

CD8+ T Cells in Atherosclerosis

Sarah Schaefer et al.

Summary: CD8(+) T cells play an important role in atherosclerosis by regulating inflammation, cell death, and plaque formation, showing therapeutic potential in treating atherosclerosis.

CELLS (2021)

Article Pharmacology & Pharmacy

Dynamic Changes of Serum Heart Type-Fatty Acid Binding Protein in Cancer Patients Treated With Immune Checkpoint Inhibitors

Ming Yuan et al.

Summary: This study examined plasma biomarker levels in cancer survivors treated with ICIs, finding that H-FABP was more sensitive than other markers in detecting potential cardiac toxicity related to ICIs.

FRONTIERS IN PHARMACOLOGY (2021)

Editorial Material Cardiac & Cardiovascular Systems

Neutrophil-lymphocyte ratio in the immune checkpoint inhibitors-related atherosclerosis

Nan Zhang et al.

EUROPEAN HEART JOURNAL (2021)

Article Cardiac & Cardiovascular Systems

Stimulation of the PD-1 Pathway Decreases Atherosclerotic Lesion Development in Ldlr Deficient Mice

Hendrika W. Grievink et al.

Summary: Stimulation of the coinhibitory PD-1 pathway can inhibit atherosclerosis development by modulating T- and B cell responses, suggesting a potential therapeutic strategy for combating atherosclerosis.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Review Oncology

Inhibitors of immune checkpoints-PD-1, PD-L1, CTLA-4-new opportunities for cancer patients and a new challenge for internists and general practitioners

Marek Z. Wojtukiewicz et al.

Summary: Immune checkpoint inhibitors (ICI) have made a significant breakthrough in cancer treatment, improving outcomes and prognosis for patients with different types of malignancy. However, the expansion of their use presents new challenges, highlighting the need for multidisciplinary teamwork to address adverse reactions.

CANCER AND METASTASIS REVIEWS (2021)

Article Cardiac & Cardiovascular Systems

Early Onset Acute Coronary Artery Occlusion After Pembrolizumab in Advanced Non-Small Cell Lung Cancer: A Case Report

Yuan Cheng et al.

Summary: Myocarditis, arrhythmia, and cardiomyopathy are the most commonly reported acute cardiotoxicities in cancer patients receiving immune checkpoint inhibitor (ICI) therapy. However, it is unclear whether ICI can cause acute coronary occlusive disease. ICIs may lead to destabilization of severely stenosed atherosclerotic plaques, which contributes to acute myocardial infarction, so caution should be exercised when treating these patients.

CARDIOVASCULAR TOXICOLOGY (2021)

Review Medical Laboratory Technology

PD-1/PD-L1 immune checkpoints: Tumor vs atherosclerotic progression

Yamin Liang et al.

Summary: The PD-1/PD-L1 pathway is crucial in immune responses and cancer therapy, but may accelerate the progression of atherosclerosis in some patients.

CLINICA CHIMICA ACTA (2021)

Article Cardiac & Cardiovascular Systems

Cardiotoxicity associated with immune checkpoint inhibitor therapy: a meta-analysis

Nestor Rubio-Infante et al.

Summary: This study estimated the incidence of cardiac irAEs in patients treated with ICIs, finding myocarditis to be the most frequent one. Despite the low incidence, the high mortality rate associated with cardiac irAEs is an important consideration. Dual ICI therapies seem to provoke higher rates of cardiac irAEs than monotherapies or ICIs plus chemotherapy.

EUROPEAN JOURNAL OF HEART FAILURE (2021)

Article Materials Science, Biomaterials

Anti-PD-L1 DNA aptamer antagonizes the interaction of PD-1/PD-L1 with antitumor effect

Tian Gao et al.

Summary: Tumor immune evasion, mediated by the PD-L1/PD-1 axis, suppresses T cell function and enables cancer cells to escape immune surveillance. The aptamer PL1 specifically binds to PD-L1, inhibiting the PD-1/PD-L1 axis and restoring T cell proliferation and function. The similar efficacy and binding capacity of aptamer PL1 as an antibody suggest its potential as an alternative therapeutic agent for cancer immunotherapy.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Review Oncology

A snapshot of the PD-1/PD-L1 pathway

Chinmoy Ghosh et al.

Summary: Immune checkpoint blockade is a promising strategy for treating cancer by reactivating anti-tumor immunity, but the response rates and resistance towards current anti-PD-1/PD-L1 therapies remain challenges. New perspectives are needed to overcome these hurdles for successful cancer treatment.

JOURNAL OF CANCER (2021)

Article Cardiac & Cardiovascular Systems

AORTIC PLAQUE PROGRESSION IN PATIENTS TREATED WITH IMMUNE CHECKPOINT INHIBITORS

Lili Zhang et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

Review Immunology

Progress and Challenges in Precise Treatment of Tumors With PD-1/PD-L1 Blockade

Youhai Jiang et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Medical Laboratory Technology

Endogenous ApoA-I expression in macrophages: A potential target for protection against atherosclerosis

Wujun Chen et al.

CLINICA CHIMICA ACTA (2020)

Review Medical Laboratory Technology

PD-1/PD-L1 in cardiovascular disease

YunFeng Sun et al.

CLINICA CHIMICA ACTA (2020)

Article Cardiac & Cardiovascular Systems

Association Between Immune Checkpoint Inhibitors With Cardiovascular Events and Atherosclerotic Plaque

Zsofia D. Drobni et al.

CIRCULATION (2020)

Review Medicine, General & Internal

Complexity of TNF-α Signaling in Heart Disease

Filip Rolski et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Review Cell Biology

Regulatory T Cell Stability and Plasticity in Atherosclerosis

Aural J. Ali et al.

CELLS (2020)

Review Biochemistry & Molecular Biology

Delicate Role of PD-L1/PD-1 Axis in Blood Vessel Inflammatory Diseases: Current Insight and Future Significance

Priya Veluswamy et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Cardiac & Cardiovascular Systems

Macrophages and T cells in atherosclerosis: a translational perspective

Benjamin Bartlett et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2019)

Meeting Abstract Cardiac & Cardiovascular Systems

CARDIOVASCULAR ONCOLOGY: EXPLORING THE EFFECTS OF IMMUNE CHECKPOINT INHIBITORS ON EXPERIMENTAL ATHEROSCLEROSIS

K. Poels et al.

ATHEROSCLEROSIS (2019)

Article Cardiac & Cardiovascular Systems

Immune checkpoint inhibition alters the inflammatory cell composition of human coronary artery atherosclerosis

Justine L. Newman et al.

CARDIOVASCULAR PATHOLOGY (2019)

Review Medicine, General & Internal

Hepatotoxicity and Recurrent NSTEMI While on Pembrolizumab for Metastatic Giant Cell Bone Tumor

Jennifer M. Kwan et al.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2019)

Article Pathology

PD-L1

Anthousa Kythreotou et al.

JOURNAL OF CLINICAL PATHOLOGY (2018)

Review Oncology

Regulatory mechanisms of PD-L1 expression in cancer cells

Yongyu Shi

CANCER IMMUNOLOGY IMMUNOTHERAPY (2018)

Article Medicine, General & Internal

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease

Marc S. Sabatine et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Oncology

PD-1 checkpoint inhibition: Toxicities and management

Andrew W. Hahn et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2017)

Article Hematology

Impairment of the Programmed Cell Death-1 Pathway Increases Atherosclerotic Lesion Development and Inflammation

De-xiu Bu et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2011)

Article Cardiac & Cardiovascular Systems

Contributions of PD-1/PD-L1 pathway to interactions of myeloid DCs with T cells in atherosclerosis

Jun Lee et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2009)

Article Medicine, Research & Experimental

Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice

Israel Gotsman et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)