☆ 4.5 Review

Antigen-specific ?? T cells contribute to cytomegalovirus control after stem cell transplantation

CURRENT OPINION IN IMMUNOLOGY (2023)

Related references

Note: Only part of the references are listed.

Article Biophysics

Results of a multicenter phase I/II trial of TCR alpha beta and CD19-depleted haploidentical hematopoietic stem cell transplantation for adult and pediatric patients

Wolfgang A. Bethge et al.

Summary: Haploidentical stem cell transplantation using TCR alpha beta/CD19-depleted grafts has shown promising results in high-risk patients, with low incidences of acute GVHD and relatively high overall and disease-free survival rates at 2 years post-transplantation.

BONE MARROW TRANSPLANTATION (2022)

Add to Collection

Article Urology & Nephrology

mTOR Inhibitors Prevent CMV Infection through the Restoration of Functional aβ and ?d T cells in Kidney Transplantation

Hannah Kaminski et al.

Summary: mTOR inhibitors have been shown to enhance T cell function and reduce the incidence of CMV infection in kidney transplant recipients. This effect may be achieved by reducing the number of dysfunctional T cells.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

Add to Collection

Editorial Material Urology & Nephrology

Disarming the Old Foe. Restoring T-Cell Immune Function with mTor-Inhibitors to Tackle Cytomegalovirus Infection

Oriol Bestard et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients

Kenichi Ishiyama et al.

Summary: The study found that memory-like natural killer (NK) cells and NKG2C-expressing CD8(+) T cells increase in renal transplant patients during cytomegalovirus (CMV) infection, playing a crucial role in combating the CMV virus. The dynamic changes of these cells during CMV viremia may be associated with controlling the virus and preventing graft rejection.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Add to Collection

Article Immunology

Evidence for an Adult-Like Type 1-Immunity Phenotype of Vδ1, Vδ2 and Vδ3 T Cells in Ghanaian Children With Repeated Exposure to Malaria

Ximena Leon-Lara et al.

Summary: This study aimed to investigate the age-dependent phenotypic composition of V delta 1(+), V delta 2(+), and V delta 3(+) T cells in children living in endemic malaria areas and how this differs between children that will develop symptomatic and asymptomatic Plasmodium falciparum infections. The results showed an established adult-like gamma delta T cell compartment in early childhood and suggested that type 1 effector V delta 1(+) T cells may serve as a biomarker for natural immunity to P. falciparum infections in young individuals from malaria-endemic settings.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Review Hematology

Immune control of cytomegalovirus reactivation in stem cell transplantation

Mariapia A. Degli-Esposti et al.

Summary: The reactivation of viruses after stem cell transplantation is a clinical challenge. Monitoring strategies and expensive antiviral drugs are needed. T cells, natural killer cells, and dendritic cells play important roles in protecting against viral reactivation. Graft-versus-host disease and new antiviral drugs may affect immune functionality and relevance.

BLOOD (2022)

Add to Collection

Article Pediatrics

Immunological recovery following HLA-matched CD3+TCR αss+/CD19+depleted hematopoietic stem cell transplantation in children

Daniela Sperl et al.

Summary: This study suggests that lymphocyte depletion technique in allogeneic HSCT could be a safe and effective alternative to conventional techniques, reducing transplant-related mortality and the incidence of acute GvHD.

PEDIATRIC TRANSPLANTATION (2022)

Add to Collection

Article Immunology

Distinct activities of Vδ1+ T-cells upon different cytomegalovirus reactivation status after haematopoietic transplantation

Ruoyang Liu et al.

Summary: This study demonstrates the unique anti-CMV activity of V delta 1(+) T-cell subset, which can directly recognize and inhibit CMV replication through TCR γδ, TLR2, and NKG2D receptor pathways. Increased CMV reactivation enhances the functional activity of V delta 1(+) T-cells, while refractory CMV reactivation impairs the function of V delta 1(+) T-cells. Furthermore, the induction of CXCL10 and IFN-β by occasional CMV reactivation can reactivate deficient V delta 1(+) T-cells in recipients with refractory CMV reactivation.

IMMUNOLOGY (2022)

Add to Collection

Article Immunology

A CMV-induced adaptive human Vδ1+ γδ T cell clone recognizes HLA-DR

Malte Deseke et al.

Summary: Deseke et al. identified HLA-DR as the cognate TCR ligand of a CMV-induced V delta 1(+) gamma delta T cell clone using soluble gamma delta TCRs and CRISPR/Cas9-mediated screening. This study provides insights into the potential role of HLA-DR in adaptive immune responses of gamma delta T cells.

JOURNAL OF EXPERIMENTAL MEDICINE (2022)

Add to Collection

Article Multidisciplinary Sciences

Atypical sideways recognition of CD1a by autoreactive γδ T cell receptors

Marcin Wegrecki et al.

Summary: In this study, the authors reveal a novel geometrically alternate sideways mode of recognition of the antigen-presenting molecule CD1a by a gamma delta T cell receptor. The gamma delta TCR binds CD1a in a lipid-independent manner and induces clustering of TCRs and T cell signaling.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Immunology

Clonal expansion and epigenetic inheritance of long-lasting NK cell memory

Timo Ruckert et al.

Summary: This study reveals the clonal expansion and long-term persistence of adaptive natural killer (NK) cells in human cytomegalovirus (HCMV) infection. The NK cell clones exhibit a convergent inflammatory memory signature and specific chromatin accessibility patterns, which shape their epigenetic memory repertoire. These findings suggest the presence of adaptive mechanisms within the human innate immune system, independent of antigen-receptor diversification.

NATURE IMMUNOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

Identification of distinct functional thymic programming of fetal and pediatric human γδ thymocytes via single-cell analysis

Guillem Sanchez Sanchez et al.

Summary: This study examines the development of gamma delta T cells in fetal and pediatric individuals using single cell RNA gene expression and gamma delta T cell receptor sequencing. The findings reveal that fetal gamma delta thymocytes exhibit a wave-like pattern of development, while pediatric thymus generates only a small subset of effector cells. The study provides insights into the distinct programming of gamma delta T cell immunity in humans.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Hematology

Haploidentical Stem Cell Transplantation After TCR-αβ+ and CD19+ Cells Depletion In Children With Congenital Non-Malignant Disease

Stefano Giardino et al.

Summary: Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is a valuable alternative treatment for nonmalignant diseases in children. This study reports the outcomes and complications of haplo-HSCT with TCR-alpha beta(+) and CD19(+) depletion conducted at the Giannina Gaslini Institute in Italy.

TRANSPLANTATION AND CELLULAR THERAPY (2022)

Add to Collection

Article Immunology

Characterization of a Unique γδ T-Cell Subset as a Specific Marker of Cytomegalovirus Infection Severity

Hannah Kaminski et al.

Summary: V gamma 9(neg)V delta 2(pos) T cells are identified as key effectors in the immune response against CMV, exhibiting significant cytotoxic potential and activation capabilities. In transplant recipients with CMV infection, the expansion of these cells is closely associated with disease severity.

JOURNAL OF INFECTIOUS DISEASES (2021)

Add to Collection

Article Multidisciplinary Sciences

Recognition of the antigen-presenting molecule MR1 by a Vd3+ δd T cell receptor

Michael T. Rice et al.

Summary: This study identifies Vδ1/2(-) γδ T cells in the blood and duodenal biopsy specimens of children that bind to MR1 tetramers in a metabolite-independent manner. Characterization of a Vδ3Vγ8 TCR clone shows that MR1 reactivity is independent of the presented antigen. The binding of the Vδ3(+) TCR to MR1 is not antigen-dependent, which sheds light on its inherent MR1 autoreactivity and strengthens the understanding of antibody-like ligand engagement by gamma delta TCRs.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Add to Collection

Article Cell Biology

Repeated Plasmodium falciparum infection in humans drives the clonal expansion of an adaptive γδ T cell repertoire

Anouk von Borstel et al.

Summary: Repeated Plasmodium falciparum infections drive clonal expansion of an adaptive gamma delta T cell repertoire, with V delta 1(+) T cells playing a role in human immune response to malaria in Malian and U.S. individuals.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Add to Collection

Article Virology

Characterization of Adaptive-like γδ T Cells in Ugandan Infants during Primary Cytomegalovirus Infection

Jessica Tuengel et al.

Summary: The study found that gamma-delta T cells develop and increase in infants during CMV infection. Different subsets of gamma-delta T cells have varied responses to CMV infection, with the frequency of NKG2C(+)CD57(+) gamma-delta T cells associated with the severity of CMV infection.

VIRUSES-BASEL (2021)

Add to Collection

Review Virology

The Contribution of Human Herpes Viruses to γδ T Cell Mobilisation in Co-Infections

Fanny Martini et al.

Summary: Gamma delta T cells are activated in various viral, bacterial, and parasitic infections. Reactivation of herpes viruses can lead to alterations in gamma delta T cells, making it important to consider co-infections and cross-protection in research regarding gamma delta T cell mobilisation.

VIRUSES-BASEL (2021)

Add to Collection

Article Immunology

A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood

Likai Tan et al.

Summary: The study reveals distinct waves of human innate-like effector gamma delta T cells in early fetal thymus, with semi-invariant V gamma 9V delta 2(+) TCR. High heterogeneity of gamma delta T cells in neonatal and adult blood is correlated with TCR usage. Effector gamma delta T cells with type 1 and type 3 innate T cell signatures were detected in embryonic thymus organogenesis.

SCIENCE IMMUNOLOGY (2021)

Add to Collection

Article Hematology

Enhanced Immune Reconstitution of γδT Cells after Allogeneic Stem Cell Transplantation Overcomes the Negative Impact of Pretransplantation Minimal Residual Disease-Positive Status in Patients with Acute Myelogenous Leukemia

Evgeny Klyuchnikov et al.

Summary: In AML patients undergoing allo-SCT, pretransplantation MRD+ status is a poor prognostic factor. Post-transplantation reconstitution of gamma delta T cells may improve outcomes in MRD+ patients, with higher levels of gamma delta T cells at +30 and +100 days associated with significantly better leukemia-free survival and overall survival, and reduced risk of relapse at +30 days.

TRANSPLANTATION AND CELLULAR THERAPY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Deciphering the regulatory landscape of fetal and adult γδ T-cell development at single-cell resolution

Sagar et al.

EMBO JOURNAL (2020)

Add to Collection

Review Immunology

Ligand recognition by the γδ TCR and discrimination between homeostasis and stress conditions

Malte Deseke et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

Add to Collection

Review Cell Biology

Engineering the Bridge between Innate and Adaptive Immunity for Cancer Immunotherapy: Focus on γδ T and NK Cells

Fabio Morandi et al.

CELLS (2020)

Add to Collection

Article Multidisciplinary Sciences

Microbial exposure drives polyclonal expansion of innate γδ T cells immediately after birth

Sarina Ravens et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Add to Collection

Article Oncology

Broad Cytotoxic Targeting of Acute Myeloid Leukemia by Polyclonal Delta One T Cells

Biagio Di Lorenzo et al.

CANCER IMMUNOLOGY RESEARCH (2019)

Add to Collection

Article Multidisciplinary Sciences

Single-cell RNA sequencing unveils the shared and the distinct cytotoxic hallmarks of human TCRVδ1 and TCRVδ2 γδ T lymphocytes

Gabriele Pizzolato et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Add to Collection

Article Cell Biology

Single-Cell Transcriptomics Identifies the Adaptation of Scart1+Vγ6+ T Cells to Skin Residency as Activated Effector Cells

Likai Tan et al.

CELL REPORTS (2019)

Add to Collection

Article Immunology

γδ TCR ligands: the quest to solve a 500-million-year-old mystery

Benjamin E. Willcox et al.

NATURE IMMUNOLOGY (2019)

Add to Collection

Article Multidisciplinary Sciences

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

Jerome Le Nours et al.

SCIENCE (2019)

Add to Collection

Article Cell & Tissue Engineering

CD8+γδ T Cells Are More Frequent in CMV Seropositive Bone Marrow Grafts and Display Phenotype of an Adaptive Immune Response

Ahmed Gaballa et al.

STEM CELLS INTERNATIONAL (2019)

Add to Collection

Article Immunology

Cytomegalovirus: an unlikely ally in the fight against blood cancers?

A. B. Bigley et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2018)

Add to Collection

Article Immunology

Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells

Quirin Hammer et al.

NATURE IMMUNOLOGY (2018)

Add to Collection

Review Immunology

Potential Beneficial effects of Cytomegalovirus infection after Transplantation

Nicolle H. R. Litjens et al.

FRONTIERS IN IMMUNOLOGY (2018)

Add to Collection

Article Microbiology

Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires

Nuray Aslan et al.

MBIO (2017)

Add to Collection

Article Multidisciplinary Sciences

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

Martin S. Davey et al.

NATURE COMMUNICATIONS (2017)

Add to Collection

Article Immunology

Apoptosis Induced via Gamma Delta T Cell Antigen Receptor Blocking Antibodies: A Cautionary Tale

Indrani Dutta et al.

FRONTIERS IN IMMUNOLOGY (2017)

Add to Collection

Article Immunology

Human γδ T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection

Sarina Ravens et al.

NATURE IMMUNOLOGY (2017)

Add to Collection

Article Hematology

Early cytomegalovirus reactivation remains associated with increased transplant-related mortality in the current era: a CIBMTR analysis

Pierre Teira et al.

BLOOD (2016)

Add to Collection

Article Oncology

Delta One T Cells for Immunotherapy of Chronic Lymphocytic Leukemia: Clinical-Grade Expansion/Differentiation and Preclinical Proof of Concept

Afonso R. Almeida et al.

CLINICAL CANCER RESEARCH (2016)

Add to Collection

Article Immunology

Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers

Sobhan Roy et al.

JOURNAL OF IMMUNOLOGY (2016)

Add to Collection

Article Microbiology

γδ T Cells Confer Protection against Murine Cytomegalovirus (MCMV)

Camille Khairallah et al.

PLOS PATHOGENS (2015)

Add to Collection

Article Microbiology

Control of Murine Cytomegalovirus Infection by γδ T Cells

Sabrina Sell et al.

PLOS PATHOGENS (2015)

Add to Collection

Article Immunology

Donor Cytomegalovirus Status Influences the Outcome of Allogeneic Stem Cell Transplant: A Study by the European Group for Blood and Marrow Transplantation

Per Ljungman et al.

CLINICAL INFECTIOUS DISEASES (2014)

Add to Collection

Review Immunology

Ontogeny of innate T lymphocytes - some innate lymphocytes are more innate then others

David Vermijlen et al.

FRONTIERS IN IMMUNOLOGY (2014)

Add to Collection

Article Oncology

γδT cells elicited by CMV reactivation after allo-SCT cross-recognize CMV and leukemia

W. Scheper et al.

LEUKEMIA (2013)

Add to Collection

Article Immunology

CD1d-lipid antigen recognition by the γδ TCR

Adam P. Uldrich et al.

NATURE IMMUNOLOGY (2013)

Add to Collection

Article Cell Biology

Deep Sequencing of the Human TCRγ and TCRβ Repertoires Suggests that TCRβ Rearranges After ab and γδ T Cell Commitment

Anna M. Sherwood et al.

SCIENCE TRANSLATIONAL MEDICINE (2011)

Add to Collection

Article Hematology

The role of Vδ2-negative γδ T cells during cytomegalovirus reactivation in recipients of allogeneic stem cell transplantation

Andrea Knight et al.

BLOOD (2010)

Add to Collection

Article Immunology

Human cytomegalovirus elicits fetal γδ T cell responses in utero

David Vermijlen et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

Add to Collection

Article Biophysics

Long term disease-free survival in acute leukemia patients recovering with increased γδ T cells after partiallymismatched related donor bone marrow transplantation

K. T. Godder et al.

BONE MARROW TRANSPLANTATION (2007)

Add to Collection

© Peeref 2019-2024. All rights reserved.