Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 81, Issue -, Pages -Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2023.102285
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Nr4a1-3 are a small family of orphan nuclear hormone receptors with transcriptional activity. Their expression reflects antigen-receptor signaling in T and B cells, and they play crucial roles in lymphocyte development, tolerance, and function. Recent advances in this field include functional roles in B cells, transcriptional targets, and mechanism of action, highlighting the integration of antigen-receptor signaling with costimulatory input and potential translational applications.
Nr4a1-3 encode a small family of orphan nuclear hormone receptors with transcriptional activity. Their expression reflects both acute and chronic antigen-receptor signaling in T and B -cells, and they have been implicated in critical aspects of lymphocyte development, tolerance, and function. These include roles in regulatory T-cell (Treg), thymic-negative selection, humoral responses, anergy, and exhaustion. Here, we review recent advances in this field such as functional roles in B-cells, transcriptional targets, and mechanism of action. We highlight recurrent themes, including integration of antigen -receptor signaling with costimulatory input, as well as unanswered questions and translational applications of this work.
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