Journal
ADVANCED MATERIALS
Volume 27, Issue 37, Pages 5547-5552Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201502003
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Funding
- NIH Director's Transformative Research Award, NIH Common Fund [HL117326]
- NSF
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A method for targeting to and retaining intravenously injected nanoparticles at the site of acute myocardial infarction in a rat model is described. Enzyme-responsive peptide-polymer amphiphiles are assembled as spherical micellar nanoparticles, and undergo a morphological transition from spherical-shaped, discrete materials to network-like assemblies when acted upon by matrix metalloproteinases (MMP-2 and MMP-9), which are up-regulated in heart tissue post-myocardial infarction.
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