4.8 Article

Sex-dependent control of pheromones on social organization within groups of wild house mice

Journal

CURRENT BIOLOGY
Volume 33, Issue 8, Pages 1407-+

Publisher

CELL PRESS
DOI: 10.1016/j.cub.2023.02.039

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In this study, the role of pheromone signals in social hierarchies and individual personalities of wild house mice was investigated. The research shows that wild mice form dominance hierarchies with sex-specific strategies. Genetic disabling of VNO-mediated pheromone detection generated opposite behavioral effects in males and females. Additionally, rank-associated personalities were abolished in mutant mice despite stable hierarchies. These findings suggest that group organization is governed by pheromone-mediated sex-specific neural circuits.
Dominance hierarchy is a fundamental social phenomenon in a wide range of mammalian species, critically affecting fitness and health. Here, we investigate the role of pheromone signals in the control of social hier-archies and individual personalities within groups of wild mice. For this purpose, we combine high -throughput behavioral phenotyping with computational tools in freely interacting groups of wild house mice, males and females, in an automated, semi-natural system. We show that wild mice form dominance hierarchies in both sexes but use sex-specific strategies, displaying distinct male-typical and female-typical behavioral personalities that were also associated with social ranking. Genetic disabling of VNO-mediated pheromone detection generated opposite behavioral effects within groups, enhancing social interactions in males and reducing them in females. Behavioral personalities in the mutated mice displayed mixtures of male-typical and female-typical behaviors, thus blurring sex differences. In addition, rank-associated per-sonalities were abolished despite the fact that both sexes of mutant mice formed stable hierarchies. These findings suggest that group organization is governed by pheromone-mediated sex-specific neural circuits and pave the way to investigate the mechanisms underlying sexual dimorphism in dominance hierarchies un-der naturalistic settings.

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