4.3 Review

Mechanistic and Therapeutic Approaches to Occupational Exposure-Associated Allergic and Non-Allergic Asthmatic Disease

Related references

Note: Only part of the references are listed.
Article Environmental Sciences

Preliminary investigation of a hypertonic saline nasal rinse as a hygienic intervention in dairy workers

Grant Erlandson et al.

Summary: This study evaluated the effectiveness of hypertonic saline nasal lavage in reducing inflammatory responses in dairy workers. The results showed significantly higher concentrations of pro- and anti-inflammatory cytokines, specifically IL-6, IL-8, and IL-10, in the treatment group compared to the control group. Further analysis revealed a positive association between hypertonic saline administration and IL-10 production. This suggests that hypertonic saline nasal lavage can reduce inflammation by upregulating anti-inflammatory cytokines.

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE (2023)

Article Public, Environmental & Occupational Health

Prevalence and Risk Factors for Pulmonary Conditions among Farmers and Ranchers in the Central United States

Jagadeesh Puvvula et al.

Summary: This study evaluates the prevalence and risk factors for work-related respiratory conditions among farm and ranch operators in the central US. The results show that farmers and ranchers have a high prevalence of respiratory conditions associated with dust and gas exposures at work. More effective protective measures are needed to reduce the risk of respiratory conditions.

JOURNAL OF AGROMEDICINE (2022)

Article Allergy

Omalizumab is effective in the preseasonal treatment of seasonal allergic rhinitis

Yuan Zhang et al.

Summary: The study found that preseasonal omalizumab therapy could significantly reduce nasal symptoms and improve quality of life in seasonal allergic rhinitis patients, with less medication usage compared to standard pharmacotherapy.

CLINICAL AND TRANSLATIONAL ALLERGY (2022)

Article Allergy

Identification of gene biomarkers with expression profiles in patients with allergic rhinitis

Yun Hao et al.

Summary: This study identified significant gene signatures in nasal mucosa and blood from allergic rhinitis patients, and highlighted potential hub genes that could be used for AR diagnosis. ROC curve analysis showed that a combination of hub genes had a high predictive performance for AR diagnosis with an AUC of 0.98.

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY (2022)

Article Multidisciplinary Sciences

Post-endotoxin exposure-induced lung inflammation and resolution consequences beneficially impacted by lung-delivered IL-10 therapy

Jill A. Poole et al.

Summary: Although lung diseases are usually caused by long-term exposures, even one-time exposure can have long-lasting consequences. This study found that endotoxin can be used to model airway inflammation and recombinant interleukin-10 (IL-10) can accelerate the recovery process.

SCIENTIFIC REPORTS (2022)

Review Allergy

TSLP, IL-33, and IL-25: Not just for allergy and helminth infection

Alison G. Stanbery et al.

Summary: The release of cytokines from epithelial and stromal cells plays a critical role in tissue immunity, with thymic stromal lymphopoietin, IL-33, and IL-25 being important regulators of type 2 immune responses. These tissue-associated cytokines not only contribute to canonical type 2 responses but also play roles in viral infections, cancer, and homeostasis.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Review Allergy

Irritant-Induced Asthma

Catherine Lemiere et al.

Summary: Irritant-induced asthma is a phenotype of asthma caused by the inhalation of irritant agents. Its diagnosis and management require considering factors such as clinical history, lung function, and bronchial hyperresponsiveness.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

Review Allergy

Spotlight on microRNAs in allergy and asthma

Julie Weidner et al.

Summary: In the past decade, miRNAs have garnered scientific interest due to their crucial role in allergic diseases, acting as master post-transcriptional regulators of cellular processes. Dysregulated miRNA expression may contribute to disease development. Research focuses on understanding the specific functions and molecular mechanisms of miRNAs in allergic diseases, particularly in regulating immune responses and responses to environmental factors.

ALLERGY (2021)

Review Allergy

Allergen immunotherapy and biologics in respiratory allergy: friends or foes?

Giacomo Malipiero et al.

Summary: Combining allergen-specific immunotherapy with other drugs or interventions that modulate type 2 immune networks can improve the safety and efficacy of treatment, providing a complex and multitargeted strategy for disease control while reducing the need for steroid administration.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Review Immunology

MCP-1: Function, regulation, and involvement in disease

Sanjiv Singh et al.

Summary: MCP-1 plays a crucial role in inflammation by attracting or enhancing the expression of other inflammatory factors/cells, leading to the development of various diseases. It is elevated in COVID-19 patients and associated with disease severity.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Article Allergy

Advances in asthma: New understandings of asthma's natural history, risk factors, underlying mechanisms, and clinical management

Rachel L. Miller et al.

Summary: In the past two years, there has been significant growth in high-quality asthma research, leading to new understandings of asthma incidence, natural history, risk factors, and potential therapeutic interventions. The progress in understanding mechanisms of asthma development and exacerbations, as well as advancements in diagnostic tools and precision approaches, have been immense and impactful. Though further knowledge on novel therapeutics and different asthma phenotypes is needed, these recent advancements offer promising avenues for future asthma management.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Review Medicine, General & Internal

Interleukin-31 as a Clinical Target for Pruritus Treatment

Kenji Kabashima et al.

Summary: IL-31 has been identified as a key player in pruritic diseases and has become a potential target for therapy. Patients suffering from pruritus experience a heavy burden and current treatments are often ineffective, highlighting the urgent need for new therapies targeting IL-31.

FRONTIERS IN MEDICINE (2021)

Review Immunology

The Role of Type 2 Innate Lymphoid Cells in Allergic Diseases

Haocheng Zheng et al.

Summary: Allergic diseases have been on the rise due to environmental changes and social development, leading to a significant public health burden. Recent studies suggest that ILC2s play important roles in allergic diseases, but further research is needed to fully understand their impact and potential treatment avenues.

FRONTIERS IN IMMUNOLOGY (2021)

Article Immunology

Allergen-Specific IgE and IgG4 as Biomarkers for Immunologic Changes during Subcutaneous Allergen Immunotherapy

Georgi Nikolov et al.

Summary: The study demonstrated that SCIT with Bulgarian allergen products resulted in significant immunological changes in most patients with allergic rhinitis. Specifically, there was an increase in allergen-specific IgG4 levels, no significant changes in sIgE levels, and a decrease in the IgE/IgG4 ratio after a 3-year course of treatment. sIgE, sIgG4, and IgE/IgG4 ratio can serve as important biomarkers to predict the immunological effectiveness of SCIT.

ANTIBODIES (2021)

Review Respiratory System

A 2019 Update on Occupational Lung Diseases: A Narrative Review

Kevin P. Vlahovich et al.

Summary: Occupational lung diseases are respiratory conditions caused, aggravated or exacerbated by workplace exposures, including asthma, hypersensitivity pneumonitis, COPD, and pulmonary fibrosis. Research advances have led to improved understanding of disease etiology, allowing for better risk analysis, screening, and mitigation strategies to not only treat diseases but also prevent and limit workplace hazards. Increased recognition of the global threat of occupational lung diseases in various occupations is driving the development of better treatments and preventive measures to protect workers' rights and ensure their continued good health.

PULMONARY THERAPY (2021)

Review Medicine, General & Internal

Occupational lung disease: A narrative review of lung conditions from the workplace

Mohd Iskandar Jumat et al.

Summary: Occupational lung diseases are lung conditions caused or worsened by workplace exposure to certain materials, impacting workers' decisions and compensations. Diseases like occupational asthma, silicosis, black lung, farmers' lung, asbestos-related disease, and hypersensitivity pneumonitis are closely related to occupational settings. Collaborative efforts from employers, workers, medical professionals, and other disciplines are essential for prevention and control of these diseases.

ANNALS OF MEDICINE AND SURGERY (2021)

Review Immunology

IL-9-producing T cells: potential players in allergy and cancer

Pornpimon Angkasekwinai et al.

Summary: IL-9-producing CD4(+)T cells are considered a unique subset of T helper cells, closely related to T(H)2 cells and potentially playing important roles in allergic diseases and cancer. Research suggests that these cells may have strong potential in treating late-stage tumors such as melanomas.

NATURE REVIEWS IMMUNOLOGY (2021)

Article Infectious Diseases

Occupational asthma

M. Cormier et al.

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE (2020)

Review Public, Environmental & Occupational Health

How to assess respiratory sensitization of low molecular weight chemicals?

Josje Arts

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH (2020)

Review Allergy

Towards definitive management of allergic rhinitis: best use of new and established therapies

Lubnaa Hossenbaccus et al.

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY (2020)

Article Allergy

EAACI Allergen Immunotherapy User's Guide

Montserrat Alvaro-Lozano et al.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2020)

Article Respiratory System

Innate lymphoid cells in isocyanate-induced asthma: role of microRNA-155

Evy E. Blomme et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

Review Medicine, General & Internal

Airway Remodeling in Asthma

Kenneth P. Hough et al.

FRONTIERS IN MEDICINE (2020)

Review Allergy

Genomics of asthma, allergy and chronic rhinosinusitis: novel concepts and relevance in airway mucosa

Anu Laulajainen-Hongisto et al.

CLINICAL AND TRANSLATIONAL ALLERGY (2020)

Article Allergy

Bronchial Response to High and Low Molecular Weight Occupational Inhalant Allergens

Agnieszka Lipinska-Ojrzanowska et al.

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH (2020)

Article Toxicology

Organic dust-induced lung injury and repair: Bi-directional regulation by TNFα and IL-10

T. A. Wyatt et al.

JOURNAL OF IMMUNOTOXICOLOGY (2020)

Article Respiratory System

MyD88 regulates a prolonged adaptation response to environmental dust exposure-induced lung disease

Amber N. Johnson et al.

RESPIRATORY RESEARCH (2020)

Editorial Material Allergy

Pollutants in the workplace: Effect on occupational asthma

Kevin J. Kelly et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Review Pediatrics

Blood Biomarkers of Sensitization and Asthma

Hans-Joachim Sonntag et al.

FRONTIERS IN PEDIATRICS (2019)

Review Respiratory System

Occupational asthma: clinical phenotypes, biomarkers, and management

Santiago Quirce et al.

CURRENT OPINION IN PULMONARY MEDICINE (2019)

Article Radiology, Nuclear Medicine & Medical Imaging

Occupational Lung Diseases: Underreported Diagnosis in Radiological Practice

Maria Antonietta Mazzei et al.

SEMINARS IN ULTRASOUND CT AND MRI (2019)

Article Physiology

MyD88 controls airway epithelial Muc5ac expression during TLR activation conditions from agricultural organic dust exposure

John D. Dickinson et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2019)

Review Allergy

Update on the Management of Occupational Asthma and Work-Exacerbated Asthma

Ambrose Lau et al.

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH (2019)

Review Allergy

Mechanisms of allergen-specific immunotherapy

Anna Globinska et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2018)

Article Public, Environmental & Occupational Health

An increase of fractional exhaled nitric oxide after specific inhalation challenge is highly predictive of occupational asthma

Julia Engel et al.

INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH (2018)

Article Allergy

Genetic variants with gene regulatory effects are associated with diisocyanate-induced asthma

David I. Bernstein et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Review Medicine, General & Internal

After asthma: redefining airways diseases

Ian D. Pavord et al.

LANCET (2018)

Review Immunology

Microbiome and Allergic Diseases

Mariona Pascal et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Immunology

Precision/Personalized Medicine in Allergic Diseases and Asthma

Umut Can Kucuksezer et al.

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2018)

Article Allergy

Mechanisms of allergen immunotherapy for inhaled allergens and predictive biomarkers

Mohamed H. Shamji et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

Review Respiratory System

Current and new challenges in occupational lung diseases

Sara De Matteis et al.

EUROPEAN RESPIRATORY REVIEW (2017)

Review Respiratory System

Asthma phenotypes and IgE responses

Antoine Froidure et al.

EUROPEAN RESPIRATORY JOURNAL (2016)

Review Allergy

Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease

Maya R. Karta et al.

CURRENT ALLERGY AND ASTHMA REPORTS (2016)

Editorial Material Allergy

Role of IgG4 in IgE-mediated allergic responses

Willem van de Veen et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

Article Allergy

Distinguishing benign from pathologic TH2 immunity in atopic children

Patrick G. Holt et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

Article Allergy

IgE in the diagnosis and treatment of allergic disease

Thomas A. E. Platts-Mills et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

Article Allergy

Circulating microRNAs as biomarkers in patients with allergic rhinitis and asthma

Ronaldo P. Panganiban et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

Review Allergy

Mechanisms of airway hyper-responsiveness in asthma: the past, present and yet to come

D. G. Chapman et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2015)

Review Immunology

Immune-microbiota interactions in health and disease

Noah W. Palm et al.

CLINICAL IMMUNOLOGY (2015)

Review Immunology

Genetics of allergy and allergic sensitization: common variants, rare mutations

Klaus Bonnelykke et al.

CURRENT OPINION IN IMMUNOLOGY (2015)

Article Public, Environmental & Occupational Health

ENDOTOXIN EXPOSURE AND CHANGES IN SHORT-TERM PULMONARY FUNCTION AMONG SEWAGE WORKERS

Marcin Cyprowski et al.

INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH (2015)

Article Allergy

IL-10-overexpressing B cells regulate innate and adaptive immune responses

Barbara Stanic et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)

Article Environmental Sciences

Managing the Risk of Occupational Allergy in the Enzyme Detergent Industry

David A. Basketter et al.

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE (2015)

Article Environmental Sciences

Setting Occupational Exposure Limits for Chemical Allergens—Understanding the Challenges

G. S. Dotson et al.

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE (2015)

Article Public, Environmental & Occupational Health

Particulate Matter, Endotoxin, and Worker Respiratory Health on Large Californian Dairies

Diane C. Mitchell et al.

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE (2015)

Review Environmental Sciences

A comprehensive review of levels and determinants of personal exposure to dust and endotoxin in livestock farming

Ioannis Basinas et al.

JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY (2015)

Article Public, Environmental & Occupational Health

Estimating the Time Interval Between Exposure to the World Trade Center Disaster and Incident Diagnoses of Obstructive Airway Disease

Michelle S. Glaser et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2014)

Review Allergy

Specific immunotherapy and biological treatments for occupational allergy

Gianna Moscato et al.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2014)

Review Immunology

HLA and asthma phenotypes/endotypes: A review

Eirini Kontakioti et al.

HUMAN IMMUNOLOGY (2014)

Letter Allergy

Seasonal increases in peripheral innatelymphoid type 2 cells are inhibited by subcutaneous grass pollen immunotherapy

Mongkol Lao-Araya et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

Review Medicine, General & Internal

Occupational Asthma

Susan M. Tarlo et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Review Immunology

Mast cell mediators: their differential release and the secretory pathways involved

Tae Chul Moon et al.

FRONTIERS IN IMMUNOLOGY (2014)

Article Public, Environmental & Occupational Health

The Respiratory Pyramid: From Symptoms to Disease in World Trade Center Exposed Firefighters

Justin K. Niles et al.

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE (2013)

Article Biochemistry & Molecular Biology

Myeloid Differentiation Factor 88-Dependent Signaling Is Critical for Acute Organic Dust-Induced Airway Inflammation in Mice

Christopher Bauer et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)

Article Allergy

Latex immunotherapy: state of the art

Eustachio Nettis et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2012)

Review Biochemistry & Molecular Biology

The Impact of the Gut Microbiota on Human Health: An Integrative View

Jose C. Clemente et al.

Article Biochemistry & Molecular Biology

Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation

David A. Hill et al.

NATURE MEDICINE (2012)

Review Public, Environmental & Occupational Health

The Evolving Spectrum of Pulmonary Disease in Responders to the World Trade Center Tragedy

Tee L. Guidotti et al.

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE (2011)

Review Immunology

The genetics of asthma and allergic disease: a 21st century perspective

Carole Ober et al.

IMMUNOLOGICAL REVIEWS (2011)

Article Allergy

Pathogenesis and Disease Mechanisms of Occupational Asthma

Zana L. Lummus et al.

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA (2011)

Article Public, Environmental & Occupational Health

Exposure to Dust and Endotoxin in Textile Processing Workers

Priyamvada Paudyal et al.

ANNALS OF OCCUPATIONAL HYGIENE (2011)

Article Respiratory System

Mucus hypersecretion in asthma: causes and effects

Christopher M. Evans et al.

CURRENT OPINION IN PULMONARY MEDICINE (2009)

Editorial Material Allergy

Omalizumab in persistent severe bakers' asthma

M. Olivieri et al.

ALLERGY (2008)

Article Biochemistry & Molecular Biology

Leukocyte-derived IL-10 reduces subepithelial fibrosis associated with chronically inhaled endotoxin

Stavros Garantziotis et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2006)

Article Otorhinolaryngology

Specific immunotherapy in inhalative allergy to rat epithelium

I Hansen et al.

LARYNGO-RHINO-OTOLOGIE (2004)

Article Respiratory System

T-cell receptor repertoire expression in workers with occupational asthma due to platinum salt

M Raulf-Heimsoth et al.

EUROPEAN RESPIRATORY JOURNAL (2000)

Article Respiratory System

Distribution of DRB1 and DQB1 HLA class II alleles in occupational asthma due to western red cedar

C Home et al.

EUROPEAN RESPIRATORY JOURNAL (2000)

Article Allergy

Specific immunotherapy with a standardized latex extract versus placebo in allergic healthcare workers

F Leynadier et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2000)