Journal
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
Volume 27, Issue 11, Pages 1805-1812Publisher
SPRINGER
DOI: 10.1007/s13361-016-1467-0
Keywords
Laser-induced acoustic desorption; Atmospheric pressure photoionization; Microplasma; Microhollow cathode discharge; Low-polarity analytes
Funding
- NSF [CHE-1504217]
- NASA Astrobiology Program under NSF Center for Chemical Evolution [CHE-1504217]
- Jet Propulsion Laboratory-Georgia Institute of Technology Strategic University Research Partnership (JPL-GIT SURP) grant
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1504217] Funding Source: National Science Foundation
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We demonstrate the first application of laser-induced acoustic desorption (LIAD) and atmospheric pressure photoionization (APPI) as a mass spectrometric method for detecting low-polarity organics. This was accomplished using a Lyman-alpha (10.2 eV) photon generating microhollow cathode discharge (MHCD) microplasma photon source in conjunction with the addition of a gas-phase molecular dopant. This combination provided a soft desorption and a relatively soft ionization technique. Selected compounds analyzed include alpha-tocopherol, perylene, cholesterol, phenanthrene, phylloquinone, and squalene. Detectable surface concentrations as low as a few pmol per spot sampled were achievable using test molecules. The combination of LIAD and APPI provided a soft desorption and ionization technique that can allow detection of labile, low-polarity, structurally complex molecules over a wide mass range with minimal fragmentation.
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