Journal
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume 186, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2023.103997
Keywords
HER2; Cancer genetics; Somatic; Tumorigenesis; Drug resistance
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HER2, a part of the Human Epidermal Growth Factor Receptor (HER) family, plays a crucial role in oncogenesis when it becomes overexpressed or mutated. This review discusses how HER2's normal pathway is altered in both overexpression and mutation, and compiles the known mechanisms by which HER2 can cause cancer. It also outlines the detection methods for HER2 mutants and overexpression, and how these detections can influence prognosis and treatment options in cancer.
The Human Epidermal Growth Factor Receptor (HER) proteins family, which includes HER2, are membrane -bound receptors that activate many intracellular pathways associated with growth and development. When there are mutations in HER2, or when it becomes overexpressed, it can cause oncogenesis and offer differential prognosis and treatment across almost all cancer types. Both mutations in HER2 and its overexpression have distinct mechanisms by which they can cause these effects in cancers. This review outlines how HER2's normal pathway is altered in both overexpression and mutation and compiles all the well-known mechanisms by which HER2 can cause oncogenesis. Finally, this review briefly outlines how HER2 mutants and HER2 overexpression is detected, and how their detection can lead to different prognosis and treatment in cancers.
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