4.6 Review

Thrombosis and cachexia in cancer: Two partners in crime?

Related references

Note: Only part of the references are listed.
Article Public, Environmental & Occupational Health

Estimated lifetime risk of venous thromboembolism in men and women in a Danish nationwide cohort: impact of competing risk of death

Carl Arne Lochen Arnesen et al.

Summary: The study estimated the lifetime risk of VTE in Danish men and women, taking into account the competing risk of death. When factoring in reproductive risk factors, women had a slightly higher lifetime VTE risk compared to men.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2022)

Article Hematology

Biomarker signatures in cancer patients with and without venous thromboembolism events: a substudy of CASSINI

Alok A. Khorana et al.

Summary: Cancer is associated with an increased risk of venous thromboembolism (VTE). In the CASSINI study, ambulatory cancer patients with a Khorana risk score >= 2 had a reduced risk of VTE while receiving rivaroxaban. This analysis used blood samples from CASSINI to compare biomarker levels between patients with and without VTE, and identified potential biomarkers for cancer-associated VTE.

BLOOD ADVANCES (2022)

Article Hematology

Plasma Levels of Leptin and Risk of Future Incident Venous Thromboembolism

Tobias Frischmuth et al.

Summary: This study investigated the association between plasma leptin levels and the risk of incident VTE. Results suggest that the apparent association between leptin levels and VTE risk is confounded by BMI, and leptin is not a relevant mediator for VTE risk in obesity.

THROMBOSIS AND HAEMOSTASIS (2022)

Review Biochemistry & Molecular Biology

Impact of hereditary thrombophilia on cancer-associated thrombosis, tumour susceptibility and progression: A review of existing evidence

Valeria Tavares et al.

Summary: This article reviews the role of genetic polymorphisms in cancer-related VTE and their impact on cancer onset and progression. However, the existing studies have inconsistent results, highlighting the need for further research and clarification.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2022)

Review Oncology

Venous thromboembolism in cancer and cancer immunotherapy

Salah Eddine Ousama Kacimi et al.

Summary: VTE is a clinical disease that frequently occurs in cancer patients, and immunotherapy, although effective for cancer treatment, can also increase the risk of VTE.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2022)

Article Health Care Sciences & Services

Immunotherapy-related skeletal muscle weakness in cancer patients: a case series

Amy H. Ng et al.

Summary: Two cases of severe autoimmune disorders, resulting in fatalities and prolonged hospitalization, were linked to immunotherapy treatment. Early symptom recognition and prompt treatment are crucial in preventing prolonged functional impairments and mortality associated with cancer immunotherapy.

ANNALS OF PALLIATIVE MEDICINE (2021)

Review Cardiac & Cardiovascular Systems

Epidemiology of Cancer-Associated Thrombosis in Asia: A Systematic Review

Lai Heng Lee et al.

Summary: The study found that the incidence of cancer-associated thrombosis in Asia is significantly higher than non-cancer associated VTE in the general population, with cancer being perhaps the most important risk factor for VTE. While the cancer sites most associated with VTE and risk factors were similar between Asian and Western studies, there is a lack of common thromboprophylaxis practices and validated risk assessment tools in Asia.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Article Hematology

CDK 4/6 inhibitors are associated with a high incidence of thrombotic events in women with breast cancer in real-world practice

Malinda T. West et al.

Summary: CDK 4/6 inhibitors are important for treating hormone receptor positive breast cancer, but can lead to VTE. This study investigated VTE incidence, risk factors, and the predictive value of the Khorana VTE risk score.

EUROPEAN JOURNAL OF HAEMATOLOGY (2021)

Article Hematology

Venous thromboembolism in cancer patients: a population-based cohort study

F. Mulder et al.

Summary: Over the past decade, the incidence of venous thromboembolism (VTE) in cancer patients may have changed due to novel cancer therapies, improved survival, and high-resolution imaging. The risk of VTE in cancer patients is steadily increasing and is ninefold higher than in the general population.

BLOOD (2021)

Article Biochemistry & Molecular Biology

Pancreatic cancer induces muscle wasting by promoting the release of pancreatic adenocarcinoma upregulated factor

Wonbeak Yoo et al.

Summary: The protein PAUF secreted by pancreatic cancer cells is identified as a key factor contributing to cancer cachexia, causing weight loss and muscle wasting in mice. High expression of PAUF is associated with increased muscle atrophy and poor overall survival in pancreatic cancer patients. Targeting PAUF may serve as a potential therapeutic strategy for pancreatic cancer-induced cachexia.

EXPERIMENTAL AND MOLECULAR MEDICINE (2021)

Review Cardiac & Cardiovascular Systems

Interplay between inflammation and thrombosis in cardiovascular pathology

Konstantin Stark et al.

Summary: Thrombosis is a major health challenge globally, with inflammation playing a crucial role in driving thrombotic diseases. Anti-inflammatory strategies show promise in targeting cardiovascular pathologies and addressing therapeutic gaps.

NATURE REVIEWS CARDIOLOGY (2021)

Article Hematology

Glioblastoma cell populations with distinct oncogenic programs release podoplanin as procoagulant extracellular vesicles

Nadim Tawil et al.

Summary: This study found that PDPN and TF in GBM activate platelets and the clotting cascade through extracellular vesicles, promoting thrombosis, which could be potential targets for treatment.

BLOOD ADVANCES (2021)

Article Hematology

Overall survival with warfarin vs. low-molecular-weight heparin in cancer-associated thrombosis

Thita Chiasakul et al.

Summary: In this population-based study, warfarin was associated with improved overall survival compared with LMWH for the treatment of cancer-associated venous thromboembolism (VTE), with the most pronounced effect seen in patients with pancreatic and gastric cancers. The survival advantage of warfarin over LMWH was consistent across subgroups including cancer stage, age, comorbidity burden, and year of VTE diagnosis.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

Review Nutrition & Dietetics

The Spectrum of Malnutrition/Cachexia/Sarcopenia in Oncology According to Different Cancer Types and Settings: A Narrative Review

Paolo Bossi et al.

Summary: The nutritional status of oncological patients is influenced by various factors, and early intervention is important. Factors such as tumor subsite, treatment type, and disease stage are related to malnutrition, while age, social factors, comorbidities, and treatment setting also play a role. Collaboration between oncologists and nutritionists is crucial for addressing and treating malnutrition effectively in this population.

NUTRIENTS (2021)

Article Oncology

The Impact of Thromboprophylaxis on the Survival of Patients with Advanced Pancreatic Cancer. The Pancreatic Cancer and Tinzaparin (PaCT) Study

Michalis Karamouzis et al.

Summary: Pancreatic cancer induces a prothrombotic state, and thromboprophylaxis with tinzaparin during chemotherapy can improve progression-free survival and reduce the risk of thrombotic events and bleeding in patients.

CANCERS (2021)

Article Medicine, Research & Experimental

Increased incidence of venous thromboembolism with cancer immunotherapy

Joanna Roopkumar et al.

Summary: The study reveals a potential association between cancer immunotherapy and venous thromboembolism, impacting overall survival. Higher levels of interleukin-8 and myeloid-derived suppressor cells may play a role in the pathogenesis of venous thromboembolism in individuals undergoing immunotherapy.
Review Gastroenterology & Hepatology

Cancer cachexia: a multifactoral disease that needs a multimodal approach

Renee Stubbins et al.

CURRENT OPINION IN GASTROENTEROLOGY (2020)

Review Oncology

Potential Mechanisms of Cancer-Related Hypercoagulability

Nicola J. Nasser et al.

CANCERS (2020)

Review Geriatrics & Gerontology

Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia

Sara Peixoto da Silva et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2020)

Meeting Abstract Biochemistry & Molecular Biology

Biological Sex Mediates Cancer Cachexia Associated Muscle Weakness

George Blackburn et al.

FASEB JOURNAL (2020)

Article Allergy

Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19

Tobias Herold et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Article Oncology

Management of Cancer Cachexia: ASCO Guideline

Eric J. Roeland et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

Review Nutrition & Dietetics

Pancreatic Cancer and Cachexia-Metabolic Mechanisms and Novel Insights

Kalliopi Anna Poulia et al.

NUTRIENTS (2020)

Review Medical Laboratory Technology

Hormones and thrombosis: risk across the reproductive years and beyond

Nicoletta Machin et al.

TRANSLATIONAL RESEARCH (2020)

Article Oncology

Understanding and Overcoming the Inflammatory Toxicities of Immunotherapy

Michael Dougan

CANCER IMMUNOLOGY RESEARCH (2020)

Review Endocrinology & Metabolism

Sex Differences in Cancer Cachexia

Xiaoling Zhong et al.

CURRENT OSTEOPOROSIS REPORTS (2020)

Article Rheumatology

Association Between Familial Mediterranean Fever and Cachexia in Females

Yunus Durmaz et al.

ARCHIVES OF RHEUMATOLOGY (2020)

Article Oncology

Targeting the IGF1R/PI3K/AKT Pathway Sensitizes Ewing Sarcoma to BET Bromodomain Inhibitors

Sudan N. Loganathan et al.

MOLECULAR CANCER THERAPEUTICS (2019)

Article Geriatrics & Gerontology

Cachexia induced by cancer and chemotherapy yield distinct perturbations to energy metabolism

Fabrizio Pin et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2019)

Article Hematology

Endogenous sex hormones and risk of venous thromboembolism in young women

Luuk J. J. Scheres et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2019)

Article Geriatrics & Gerontology

The clinical relevance of adiposity when assessing muscle health in men treated with androgen deprivation for prostate cancer

Patrick J. Owen et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2019)

Editorial Material Geriatrics & Gerontology

Kidney cachexia or protein-energy wasting in chronic kidney disease: facts and numbers

Laetitia Koppe et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2019)

Article Geriatrics & Gerontology

Cancer cachexia induces morphological and inflammatory changes in the intestinal mucosa

Raquel G. F. Costa et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2019)

Article Hematology

Predicting venous thromboembolism in multiple myeloma: development and validation of the IMPEDE VTE score

Kristen M. Sanfilippo et al.

AMERICAN JOURNAL OF HEMATOLOGY (2019)

Review Hematology

Roles of Coagulation Proteases and PARs (Protease-Activated Receptors) in Mouse Models of Inflammatory Diseases

Jens J. Posma et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)

Article Biochemistry & Molecular Biology

PAR2 promotes M1 macrophage polarization and inflammation via FOXO1 pathway

Liang Chen et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

Review Health Care Sciences & Services

Measuring cachexia-diagnostic criteria

Rony Dev

ANNALS OF PALLIATIVE MEDICINE (2019)

Review Immunology

Cell Type-Specific Roles of NF-κB Linking Inflammation and Thrombosis

Marion Mussbacher et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Respiratory System

It's more than low BMI: prevalence of cachexia and associated mortality in COPD

Merry-Lynn N. McDonald et al.

RESPIRATORY RESEARCH (2019)

Review Respiratory System

Cancer-associated thrombosis: the when, how and why

Caio J. Fernandes et al.

EUROPEAN RESPIRATORY REVIEW (2019)

Article Geriatrics & Gerontology

Differentially expressed alternatively spliced genes in skeletal muscle from cancer patients with cachexia

Ashok Narasimhan et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2018)

Review Hematology

Tissue Factor: An Essential Mediator of Hemostasis and Trigger of Thrombosis

Steven P. Grover et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)

Review Medicine, Research & Experimental

Platinum-induced muscle wasting in cancer chemotherapy: Mechanisms and potential targets for therapeutic intervention

Alexandra Moreira-Pais et al.

LIFE SCIENCES (2018)

Article Hematology

Updated clinical models for VTE prediction in hospitalized medical patients

Grigoris T. Gerotziafas et al.

THROMBOSIS RESEARCH (2018)

Article Geriatrics & Gerontology

Circulating monocyte chemoattractant protein-1 (MCP-1) is associated with cachexia in treatment-naive pancreatic cancer patients

Erin E. Talbert et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2018)

Article Medicine, General & Internal

Cancer-associated cachexia

Vickie E. Baracos et al.

NATURE REVIEWS DISEASE PRIMERS (2018)

Review Hematology

Vitamin K-Dependent Coagulation Factors That May be Responsible for Both Bleeding and Thrombosis (FII, FVII, and FIX)

Antonio Girolami et al.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2018)

Article Geriatrics & Gerontology

New genetic signatures associated with cancer cachexia as defined by low skeletal muscle index and weight loss

Neil Johns et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2017)

Article Hematology

Predicting the risk of cancer after unprovoked venous thromboembolism: external validation of the RIETE score

L. Bertoletti et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2017)

Editorial Material Hematology

Occult cancer screening in patients with venous thromboembolism: guidance from the SSC of the ISTH

A. Delluc et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2017)

Article Hematology

Increased thrombin generation in a mouse model of cancer cachexia is partially interleukin-6 dependent

C. J. Reddel et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2017)

Review Medicine, Research & Experimental

TNF-α and cancer cachexia: Molecular insights and clinical implications

Hetal J. Patel et al.

LIFE SCIENCES (2017)

Review Nutrition & Dietetics

Cancer Cachexia: Cause, Diagnosis, and Treatment

Todd W. Mattox

NUTRITION IN CLINICAL PRACTICE (2017)

Review Oncology

Cancer and Venous Thromboembolic Disease: A Review

Eoin Donnellan et al.

ONCOLOGIST (2017)

Article Hematology

Venous thromboembolism: Past, present and future

Sam Schulman et al.

THROMBOSIS AND HAEMOSTASIS (2017)

Review Hematology

Cancer-associated venous thromboembolism: Burden, mechanisms, and management

Cihan Ay et al.

THROMBOSIS AND HAEMOSTASIS (2017)

Review Oncology

Supportive care in pancreatic ductal adenocarcinoma

B. Laquente et al.

CLINICAL & TRANSLATIONAL ONCOLOGY (2017)

Review Nutrition & Dietetics

ESPEN expert group recommendations for action against cancer-related malnutrition

J. Arends et al.

CLINICAL NUTRITION (2017)

Review Oncology

Mechanisms and risk factors of thrombosis in cancer

Anna Falange et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2017)

Article Nutrition & Dietetics

ESPEN guidelines on definitions and terminology of clinical nutrition

T. Cederholm et al.

CLINICAL NUTRITION (2017)

Article Oncology

Identification of neutrophil-derived proteases and angiotensin II as biomarkers of cancer cachexia

Claudia A. Penafuerte et al.

BRITISH JOURNAL OF CANCER (2016)

Article Cardiac & Cardiovascular Systems

Cross Talk Pathways Between Coagulation and Inflammation

Jonathan H. Foley et al.

CIRCULATION RESEARCH (2016)

Review Cell Biology

Mechanisms of metabolic dysfunction in cancer-associated cachexia

Michele Petruzzelli et al.

GENES & DEVELOPMENT (2016)

Article Cardiac & Cardiovascular Systems

The epidemiology of venous thromboembolism

John A. Heit et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2016)

Article Medicine, General & Internal

Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer

G. N. Hortobagyi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Review Biochemistry & Molecular Biology

Hypothalamic inflammation and food intake regulation during chronic illness

J. T. Dwarkasing et al.

PEPTIDES (2016)

Review Hematology

Environmental and Genetic Risk Factors Associated with Venous Thromboembolism

Marta Crous-Bou et al.

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2016)

Review Medicine, General & Internal

Proteinase-Activated Receptor 2 Is a Novel Regulator of TGF-β Signaling in Pancreatic Cancer

David Witte et al.

JOURNAL OF CLINICAL MEDICINE (2016)

Review Hematology

Fibrinolysis and the control of blood coagulation

John C. Chapin et al.

BLOOD REVIEWS (2015)

Review Geriatrics & Gerontology

Pathophysiology of anorexia in the cancer cachexia syndrome

Chukwuemeka Charles Ezeoke et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2015)

Review Oncology

Malnutrition and cachexia in patients with head and neck cancer treated with (chemo)radiotherapy

Mojca Gorenc et al.

REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY (2015)

Article Oncology

Can Megestrol Acetate Induce Thrombosis in Advanced Oncology Patients Receiving Chemotherapy?

Cetin Ordu et al.

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION (2014)

Article Pharmacology & Pharmacy

Mechanisms Linking Leptin to Arterial and Venous Thrombosis: Potential Pharmacological Targets

Katrin Schaefer et al.

CURRENT PHARMACEUTICAL DESIGN (2014)

Article Hematology

Cancer-associated unsuspected pulmonary embolism

Nick van Es et al.

THROMBOSIS RESEARCH (2014)

Article Geriatrics & Gerontology

Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexia syndrome: preclinical profile

Claudio Pietra et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2014)

Editorial Material Geriatrics & Gerontology

Prevalence, incidence and clinical impact of cachexia: facts and numbers-update 2014

Stephan von Haehling et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2014)

Review Hematology

Epidemiology of cancer-associated venous thrombosis

Jasmijn F. Timp et al.

BLOOD (2013)

Article Medicine, Research & Experimental

NF-κB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia

Wei A. He et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Medicine, General & Internal

Crizotinib versus Chemotherapy in Advanced ALK-Positive Lung Cancer

Alice T. Shaw et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Review Oncology

Leptin signaling and leptin resistance

Yingjiang Zhou et al.

FRONTIERS OF MEDICINE (2013)

Article Medicine, Research & Experimental

P-selectin genotype is associated with the development of cancer cachexia

Benjamin H. L. Tan et al.

EMBO MOLECULAR MEDICINE (2012)

Article Medicine, General & Internal

Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma

Keith T. Flaherty et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Review Genetics & Heredity

Identification of possible genetic polymorphisms involved in cancer cachexia: a systematic review

Benjamin H. L. Tan et al.

JOURNAL OF GENETICS (2011)

Article Respiratory System

Chronic kidney disease and venous thromboembolism: epidemiology and mechanisms

Keattiyoat Wattanakit et al.

CURRENT OPINION IN PULMONARY MEDICINE (2009)

Review Oncology

Venous Thromboembolism in the Hematologic Malignancies

Anna Falanga et al.

JOURNAL OF CLINICAL ONCOLOGY (2009)

Review Biochemistry & Molecular Biology

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

Satish L. Deshmane et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2009)

Article Immunology

Effects of the hormones of the thyroid axis on the vitamin K-dependent plasma factors of blood coagulation (II, VII, IX and X)

N. N. Negrev et al.

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2008)

Review Oncology

The lethal phenotype of cancer: The molecular basis of death due to malignancy

Robert D. Loberg et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2007)

Article Oncology

Tissue factor expression, angiogenesis, and thrombosis in pancreatic cancer

Alok A. Khorana et al.

CLINICAL CANCER RESEARCH (2007)

Letter Hematology

Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy

A. A. Khorana et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2007)

Review Physiology

Molecular pathways leading to cancer cachexia

MJ Tisdale

PHYSIOLOGY (2005)

Review Oncology

The prothrombotic state in cancer: pathogenic mechanisms

M De Cicco

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2004)

Article Medicine, Research & Experimental

Selectin-mucin interactions as a probable molecular explanation for the association of Trousseau syndrome with mucinous adenocarcinomas

M Wahrenbrock et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

Article Critical Care Medicine

The protein C pathway

CT Esmon

CHEST (2003)

Article Critical Care Medicine

Thrombin interactions

E Di Cera

CHEST (2003)

Article Hematology

Malignancy, thrombosis and Trousseau: the case for an eponym

AA Khorana

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2003)

Article Cardiac & Cardiovascular Systems

Pulmonary cachexia

AMWJ Schols

INTERNATIONAL JOURNAL OF CARDIOLOGY (2002)

Article Hematology

Pathogenesis of thrombosis in patients with malignancy

A Falanga et al.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2001)

Article Medicine, General & Internal

Risk factors for deep vein thrombosis and pulmonary embolism -: A population-based case-control study

JA Heit et al.

ARCHIVES OF INTERNAL MEDICINE (2000)