Transcriptomic analysis of esophageal cancer reveals hub genes and networks involved in cancer progression

Esophageal carcinoma (ESCA) has a 5-year survival rate of fewer than 20%. The study aimed to identify new predictive biomarkers for ESCA through transcriptomics meta-analysis to address the problems of ineffective cancer therapy, lack of efficient diagnostic tools, and costly screening and contribute to developing more efficient cancer screening and treatments by identifying new marker genes. Nine GEO datasets of three kinds of esophageal carcinoma were analyzed, and 20 differentially expressed genes were detected in carcinogenic pathways. Network analysis revealed four hub genes, namely RAR Related Orphan Receptor A (RORA), lysine acetyltransferase 2B (KAT2B), Cell Division Cycle 25B (CDC25B), and Epithelial Cell Transforming 2 (ECT2). Overexpression of RORA, KAT2B, and ECT2 was identified with a bad prognosis. These hub genes modulate immune cell infiltration. These hub genes modulate immune cell infiltration. Although this research needs lab confirmation, we found interesting biomarkers in ESCA that may aid in diagnosis and treatment.

Automated summary

Through transcriptomics meta-analysis, new predictive biomarkers for esophageal carcinoma were identified, offering solutions to the problems of ineffective cancer therapy, lack of efficient diagnostic tools, and costly screening. Four hub genes, including RORA, KAT2B, CDC25B, and ECT2, were discovered to play a regulatory role in carcinogenic pathways and were associated with poor prognosis.