Journal
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
Volume 231, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cmpb.2023.107409
Keywords
Computational modelling; Fluid-structure interaction; Bariatric surgery; Gerd; His-angle; Bolus viscosity
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This study investigated the mechanism of gastro-oesophageal reflux disease (GERD) using computational models. It found that laparoscopic sleeve gastrectomy could induce de novo GERD and worsen pre-existing GERD. Variables such as the His-angle, antral dimension, and bolus viscosity were found to affect reflux increase.
Background and Objectives: Gastro-oesophageal reflux disease (GERD) consists in the passage of gastric acid content from the stomach to the oesophagus, causing burns and deteriorating the quality of life. La-paroscopic Sleeve Gastrectomy (LSG) could induce de novo GERD and worsen pre-existing GERD because of the higher gastric pressurisation, reduction of stomach volume and a wider His-angle. In the proposed work, various computational gastric 2D models were developed to understand the effects of variables such as the His-angle, the antral dimension, and the bolus viscosity on the reflux increase.Methods: Fluid-Structure Interaction (FSI) computational models which couple the solid mechanics of the gastric wall, and the fluid domain of the bolus, have been developed to shed light on biomechanical aspects of GERD after LSG. A closure was imposed to the lower oesophageal sphincter (LES) mimicking what happens physiologically after food intake.Results: Results showed that the configuration prone to higher reflux flow was the post-surgical 65 degrees model with a staple line starting directly from the pylorus without antral preservation, for all considered viscosities. Increasing viscosity, reflux flow decreased. Post-surgical refluxes were higher than pre-ones and decreased with increasing antrum preservation.Conclusions: These results could be a starting point for analysis of anatomical features, bariatric surgery and GERD occurrence. Further studies based on 3D geometries need to be performed.(c) 2023 Elsevier B.V. All rights reserved.
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