Recent advances in stimuli-responsive nano-heterojunctions for tumor therapy

Stimuli-responsive catalytic therapy based on nano-catalysts has attracted much attention in the field of biomedicine for tumor therapy, due to its excellent and unique properties. However, the complex tumor microenvironment conditions and the rapid charge recombination in the catalyst limit catalytic therapy's effectiveness and further development. Effective heterojunction nanomaterials are constructed to address these problems to improve catalytic performance. Specifically, on the one hand, the band gap of the material is adjusted through the heterojunction structure to promote the charge separation efficiency under exogenous stimulation and further improve the catalytic capacity. On the other hand, the construction of a heterojunction structure can not only preserve the function of the original catalyst but also achieve significantly enhanced synergistic therapy ability. This review summarized the construction and functions of stimuli-responsive heterojunction nanomaterials under the excitation of X-rays, visible-near infrared light, and ultrasound in recent years, and further introduces their application in cancer therapy. Hopefully, the summary of stimuli-responsive heterojunction nanomaterials' applications will help researchers promote the development of nanomaterials in cancer therapy.

Automated summary

Stimuli-responsive catalytic therapy using nano-catalysts has gained significant attention in the field of biomedicine for tumor therapy. However, challenges such as the complex tumor microenvironment and rapid charge recombination in the catalyst have limited the effectiveness and development of catalytic therapy. To overcome these limitations, effective heterojunction nanomaterials have been developed, which can adjust the band gap to enhance charge separation efficiency and preserve the function of the original catalyst while achieving enhanced synergistic therapy ability.