Journal
ADVANCED MATERIALS
Volume 28, Issue 4, Pages 677-684Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201503310
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Funding
- National Institutes of Health [HL092836, EB02597, AR057837, HL099073]
- National Science Foundation [DMR0847287]
- Office of Naval Research Young Investigator award
- ONR PECASE Award
- National Sciences and Engineering Research Council of Canada
- Universita degli Study di Roma La Sapienza
- Institute for Soldier Nanotechnology
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A novel bioink and a dispensing technique for 3D tissue-engineering applications are presented. The technique incorporates a coaxial extrusion needle using a low-viscosity cell-laden bioink to produce highly defined 3D biostructures. The extrusion system is then coupled to a microfluidic device to control the bioink arrangement deposition, demonstrating the versatility of the bioprinting technique. This low-viscosity cell-responsive bioink promotes cell migration and alignment within each fiber organizing the encapsulated cells.
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