Changes of gut microbiota in patients at different phases of stroke

AimsGut dysbiosis appears rapidly after acute stroke and may affect the prognosis, whereas changes in gut microbiota with gradual recovery from stroke are unknown and rarely studied. The purpose of this study is to explore the characteristics of gut microbiota changes over time after stroke. MethodsStroke patients and healthy subjects were selected to compare the clinical data and gut microbiota of the patient group in two phases with that of healthy subjects and 16S rRNA gene sequencing was used to search the differences of gut microbiota in subjects. ResultsCompared with the healthy subjects, the subacute patients mainly decreased the abundance of some gut microbial communities, while the decreased communities reduced and more communities increased the abundance in the convalescent patients. The abundance of Lactobacillaceae increased in both phases in patient group, while Butyricimona, Peptostreptococaceae and Romboutsia decreased in both phases. Correlation analysis found that the MMSE scores of patients in the two phases had the greatest correlation with the gut microbiota. ConclusionGut dysbiosis still existed in patients in the subacute phase and convalescent phase, and gradually improved with the recovery of stroke. Gut microbiota may affect the prognosis of stroke by affecting BMI and/or related indicators, and there is a strong correlation between gut microbiota and cognitive function after stroke.

Automated summary

The study aims to explore the characteristics of gut microbiota changes over time after stroke. The researchers compared the clinical data and gut microbiota of stroke patients and healthy subjects in two phases. The results showed that gut dysbiosis still existed in patients in the subacute phase and convalescent phase of stroke, and gradually improved with the recovery of stroke. There is a strong correlation between gut microbiota and cognitive function after stroke.