Journal
CLINICS IN CHEST MEDICINE
Volume 44, Issue 2, Pages 263-277Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccm.2022.11.019
Keywords
COVID-19; Pulmonary function test; Computed tomography; Biopsy; Sequelae; PASC; Pulmonary fibrosis
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Post-COVID sequelae, such as lung injury and PASC, present complex and poorly understood manifestations, mechanisms, and outcomes in both short and long term. Supportive therapy remains the main approach, while extensive research aims to better understand and identify pathways for intervention. Historical insights are important to determine whether current observations are genuinely novel or represent previously overlooked or misunderstood syndromes.
Post-COVID sequelae including lung injury and PASC are complex and poorly understood, repre-senting heterogenous manifestations, mecha-nisms, and short-and long-term outcomes. The mainstay of therapy remains mostly supportive, though robust research is underway to better un-derstand and characterize pathways for interven-tion. Historical insight remains important to clarify whether current observations are truly novel or representative of previously ignored or misunder-stood syndromes.
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