Adapting international clinical trials during COVID-19 and beyond

Article Medicine, Research & Experimental

The COVID-19 pandemic and new clinical trial activations

Joseph M. Unger et al.

Summary: The study found a significant decrease in the activation of clinical trials in the US during the COVID-19 pandemic, compared to trials conducted outside the US. Additionally, the rebound in trial activations during the initial reopening phase was weaker for US-based studies compared to non-US-based studies.

TRIALS (2021)

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Article Medical Informatics

Risk-Based Monitoring in Clinical Trials: Past, Present, and Future

Brian Barnes et al.

Summary: The ACRO survey found that 22% of clinical trials included at least one RBM component, with centralized monitoring being the most widely implemented and reduced source document review being the least implemented. Despite the shift to off-site monitoring during the COVID-19 pandemic, monitoring effectiveness remained consistent, suggesting the potential benefits of increased RBM uptake in a post-pandemic environment.

THERAPEUTIC INNOVATION & REGULATORY SCIENCE (2021)

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Editorial Material Surgery