Journal
CLINICAL RESPIRATORY JOURNAL
Volume 17, Issue 4, Pages 270-276Publisher
WILEY
DOI: 10.1111/crj.13590
Keywords
anti-SARS-CoV-2 spike IgG antibody; anti-SARS-CoV-2 spike IgM antibody; IL-6; inactivated vaccine; lymphocyte; SARS-CoV-2
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This study found that patients with breakthrough infections after receiving the COVID-19 vaccine had higher lymphocyte counts, anti-SARS-CoV-2 spike IgG and IgM antibody titers within 60 days of receiving the second dose compared to those with a 60-day or longer interval. Additionally, the IL-6 level was significantly lower in the group with a shorter interval.
BackgroundUnderstanding of the early immune response in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infections is limited. MethodsNinety-eight patients with coronavirus disease 2019 (COVID-19) breakthrough infections were divided into two groups, with intervals from receiving the second dose of inactivated vaccine to the onset of illness The median lymphocyte count and the median anti-SARS-CoV-2 spike immunoglobulin G (IgG) and immunoglobulin M (IgM) titers were higher in the <60-day interval group compared with the corresponding medians in the >= 60-day interval group (p = 0.005, p = 0.001, and p = 0.001, respectively). The median interleukin-6 (IL-6) level in the <60-day interval group was significantly lower than the median IL-6 level in the >= 60-day interval group (p < 0.001). ConclusionsOur results highlight the different anti-SARS-CoV-2 spike IgG and IgM antibody titers among patients with different intervals from receiving the second dose of inactivated vaccine to the onset of illness.
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