Effect of Various Dosing Schedules on the Pharmacokinetics of Oral Semaglutide: A Randomised Trial in Healthy Subjects

Review Pharmacology & Pharmacy

Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions

Vivaswath S. Ayyar et al.

Summary: Circadian rhythms are important biological clock mechanisms that regulate physiological, biochemical, and behavioral processes. They are controlled by central and peripheral clocks, with external cues influencing their function. Disruption of these rhythms has direct consequences for health and drug efficacy.

JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2021)

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Article Biochemistry & Molecular Biology

Effect of oral semaglutide on the pharmacokinetics of thyroxine after dosing of levothyroxine and the influence of co-administered tablets on the pharmacokinetics of oral semaglutide in healthy subjects: an open-label, one-sequence crossover, single-center, multiple-dose, two-part trial

Camilla Hauge et al.

Summary: The study showed that co-administration of oral semaglutide and levothyroxine influenced the pharmacokinetics of levothyroxine, while co-administration of oral semaglutide with multiple tablets decreased the exposure of semaglutide. Monitoring of thyroid parameters is recommended for patients receiving both oral semaglutide and levothyroxine.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2021)

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Article Endocrinology & Metabolism

Effect of Various Dosing Conditions on the Pharmacokinetics of Oral Semaglutide, a Human Glucagon-Like Peptide-1 Analogue in a Tablet Formulation

Tine A. Baekdal et al.

Summary: The study found that administration of oral semaglutide in a fasting state with up to 120mL water and at least 30 minutes post-dose fasting results in clinically relevant semaglutide exposure. These dosing conditions have been used in phase 3 trials and are part of the approved label.

DIABETES THERAPY (2021)

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Review Endocrinology & Metabolism