Journal
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
Volume 64, Issue 12, Pages 2479-2486Publisher
WILEY-BLACKWELL
DOI: 10.1111/jgs.14402
Keywords
physical activity; APOE e4; mild cognitive impairment
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Funding
- Baxter
- Elan Pharmaceuticals
- NIH
- National Institutes of Health (NIH) grant: National Institute of Mental Health [K01 MH068351]
- National Institutes of Health (NIH) grant: National Institute on Aging [U01 AG006786, K01 AG028573]
- National Institutes of Health (NIH) grant: NIH [R01 AG034676]
- Robert Wood Johnson Foundation
- Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program
- European Regional Development Fund: FNUSA-ICRC [CZ.1.05/1.1.00/02.0123]
- Arizona Alzheimer's Consortium
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OBJECTIVES: To investigate the timing (mid-vs late life) of physical activity, apolipoprotein (APO) E epsilon 4, and risk of incident mild cognitive impairment (MCI). DESIGN: Prospective cohort study. SETTING: Mayo Clinic Study of Aging (Olmsted County, MN). PARTICIPANTS: Cognitively normal elderly adults (N = 1,830, median age 78, 50.2% female). MEASUREMENTS: Light, moderate, and vigorous physical activities in mid-and late life were assessed using a validated questionnaire. An expert consensus panel measured MCI based on published criteria. Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) with age as a time scale after adjusting for sex, education, medical comorbidity, and depression. RESULTS: Light (HR = 0.58, 95% CI = 0.43-0.79) and vigorous (HR = 0.78, 95% CI = 0.63-0.97) physical activity in midlife were associated with lower risk of incident MCI. The association between moderate activity and incident MCI was not significant (HR = 0.85, 95% CI = 0.67-1.09). In late life, light (HR = 0.75, 95% CI = 0.58-0.97) and moderate (HR = 0.81, 95% CI = 0.660.99) but not vigorous physical activity were associated with lower risk of incident MCI. A synergistic interaction was also observed between mid-and late-life activity in reducing risk of incident MCI. Furthermore, APOE epsilon 4 carriers who did not exercise had a higher risk of incident MCI than noncarriers who reported physical activity. CONCLUSION: Physical activity reduced the risk of incident MCI. Exercising in mid-and late life had an additive synergistic interaction in reducing the risk of MCI.
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