Preservation of functional descending input to paralyzed upper extremity muscles in motor complete cervical spinal cord injury

Objective: Spinal cord injury (SCI) is classified as complete or incomplete depending on the extent of sen-sorimotor preservation below the injury level. However, individuals with complete SCIs can voluntarily activate paralyzed lower limb muscles alone or by engaging non-paralyzed muscles during neurophysi-ological assessments, indicating presence of residual pathways across the injury. However, similar phe-nomena have not been explored for the upper extremity (UE) muscles following cervical SCIs.Methods: Eighteen individuals with motor complete cervical SCI (AIS A or B) and five age-matched non-injured (NI) individuals performed various UE events against manual resistance during functional neuro-physiological assessment (FNPA), and electromyographic (EMG) activity was recorded from UE muscles. Results: Our findings demonstrated i) voluntary activation of clinically paralyzed muscles as evident from EMG readouts, ii) increased activity in these muscles during events engaging muscles above the injury level, iii) reduced spectral properties of paralyzed muscles in SCI compared to NI participants.Conclusions: Functional EMG activity in clinically paralyzed muscles indicate presence of residual path-ways across the injury establishing supralesional control over the sublesional neural circuitry.Significance: The findings may help explain the neurophysiological basis for UE recovery and can be exploited in designing rehabilitation techniques to facilitate UE recovery following cervical SCIs.(c) 2023 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

Automated summary

This study explored functional electromyographic (EMG) activity in upper extremity muscles following cervical spinal cord injury (SCI). The findings showed voluntary activation of clinically paralyzed muscles, increased activity in these muscles during events engaging muscles above the injury level, and reduced spectral properties of paralyzed muscles compared to non-injured participants. These findings are significant for understanding upper extremity recovery and designing rehabilitation techniques for cervical SCI.