Total oxidant/antioxidant status, copper and zinc levels in acute ischemic stroke patients after mechanical thrombectomy

Background and purpose: We aimed to identify the relationship of total antioxidant status, total oxidant status, and copper (Cu) and zinc (Zn) situations with the short-term prognostic and stroke severity in acute ischemic stroke cases who were successfully recanalized by mechanical thrombectomy. Methods: A study of 36 acute ischemic stroke patients and 22 controls were prospectively studied. Tube samples were attained at admission and 24 h after recanalization. In patients who were successfully recanalized (thrombolysis in cerebral infarction >= 2b), a 3-month modified Rankin scale (mRS) score of 0-2 was considered a good prognosis, and a score of 3-6 was considered a poor prognosis. Results: Admission Cu levels were significantly higher in the poor prognosis group (p = 0.031). In the multivariate logistic regression analysis, Cu was not associated with poor prognosis (p = 0.357). Cu and Zn levels were lower in the patients group compared to controls (p = 0.014 and p = 0.010, respectively). There was no correlation between National Institute of Health Stroke Scale and biomarkers (p > 0.05). The temporal variation of biomarkers did not differ significantly between the good prognosis and poor prognosis groups (p interaction > 0.05). Conclusions: High admission Cu levels were associated with poor prognosis, but this association was limited. In addition, Cu and Zn levels were statistically lower in patients. There was no relationship between total antioxidant/oxidant status and short-term prognosis or stroke severity

Automated summary

This study aimed to investigate the relationship between total antioxidant status, total oxidant status, and copper and zinc situations and the short-term prognosis and stroke severity in patients with acute ischemic stroke who were successfully recanalized by mechanical thrombectomy. The study found that high admission copper levels were associated with poor prognosis, but this association was limited. In addition, copper and zinc levels were lower in patients. There was no relationship between total antioxidant/oxidant status and short-term prognosis or stroke severity.