Human Immunodeficiency Virus (HIV) Seroconversion Among Men Who Have Sex With Men Who Use Event-driven or Daily Oral Pre-exposure Prophylaxis (CohMSM-PrEP): A Multi-country Demonstration Study From West Africa

Article Immunology

Characterizing HIV-Preventive, Plasma Tenofovir Concentrations-A Pooled Participant-level Data Analysis From Human Immunodeficiency Virus Preexposure Prophylaxis (PrEP) Clinical Trials

Maria Garcia-Cremades et al.

Summary: This study aimed to estimate the protective plasma concentration of tenofovir and found that high-risk women need higher levels of plasma tenofovir to prevent HIV acquisition than men.

CLINICAL INFECTIOUS DISEASES (2022)

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Article Immunology

Daily and on-demand HIV pre-exposure prophylaxis with emtricitabine and tenofovir disoproxil (ANRS PREVENIR): a prospective observational cohort study

Jean-Michel Molina et al.

Summary: This study provides insights into the effectiveness of on-demand pre-exposure prophylaxis (PrEP) for HIV prevention. The results suggest that on-demand PrEP is a valid alternative to daily PrEP in reducing HIV-1 incidence among high-risk individuals.

LANCET HIV (2022)

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Article Public, Environmental & Occupational Health

Socio-behavioral correlates of pre-exposure prophylaxis use and correct adherence in men who have sex with men in West Africa

August Eubanks et al.

Summary: In this study conducted in West Africa, it was found that PrEP use and correct adherence rates were relatively high among MSM participants. Community-based clinic attendance and condomless anal sex were associated with higher PrEP engagement, while socially and economically marginalized participants faced difficulties in adherence. Extra support should be provided for these vulnerable users.

BMC PUBLIC HEALTH (2022)

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Article Immunology

Adherence to event-driven HIV PrEP among men who have sex with men in Amsterdam, the Netherlands: analysis based on online diary data, 3-monthly questionnaires and intracellular TFV-DP

Vita W. Jongen et al.

Summary: The study found high adherence to edPrEP among MSM, with most condomless anal sex acts being effectively protected, confirming the efficacy of edPrEP in preventing HIV acquisition. Blood sample analysis also indicated an average of two to three tablets per week being taken.

JOURNAL OF THE INTERNATIONAL AIDS SOCIETY (2021)

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Article Public, Environmental & Occupational Health

Adherence to quarterly HIV prevention services and its impact on HIV incidence in men who have sex with men in West Africa (CohMSM ANRS 12324-Expertise France)

Ter Tiero Elias Dah et al.

Summary: Access to tailored HIV prevention services for MSM in West Africa remains limited. High adherence to quarterly HIV prevention services was observed, but the HIV epidemic among MSM is still a concern, emphasizing the need for strengthening prevention services, including the use of PrEP.

BMC PUBLIC HEALTH (2021)

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Article Immunology

Long-term protection from HIV infection with oral HIV pre-exposure prophylaxis in gay and bisexual men: findings from the expanded and extended EPIC-NSW prospective implementation study

Andrew E. Grulich et al.

Summary: This study found that HIV incidence remained low over up to 3 years of follow-up in individuals at high risk who were prescribed PrEP. Factors associated with increased HIV incidence included being younger, living in areas with fewer gay men, reporting more risk behaviors at baseline, and having lower medication possession ratio (MPR). Overall, the study showed that with affordable PrEP and associated healthcare services, low HIV incidence rates can be maintained in high-risk populations.

LANCET HIV (2021)

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Article Immunology

HIV pre-exposure prophylaxis for men who have sex with men in west Africa: a multicountry demonstration study

Christian Laurent et al.

Summary: The study on HIV pre-exposure prophylaxis (PrEP) in men who have sex with men (MSM) in West Africa showed that PrEP could effectively prevent HIV infection without increasing risky sexual behaviors or other sexually transmitted infections. Urgent implementation of PrEP in West Africa is recommended, with special attention to retention in care and PrEP adherence to ensure its full prevention potential.

LANCET HIV (2021)

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Article Medicine, General & Internal